Chirongwa cheArthritis Medication
Arthritis mishonga yakagara ichionekwa se "tsika" yekurapa. Sezvo munhu mumwe chete apindurwa nemishonga inogona kusiyana uye nokuti zvinogona kuitika nemishuwo yakaipa inobatsirawo, kuwana mishonga inoshanda yakawanda yemishonga yeArthritis inogona kunge iri nzira yakaoma kupfuura yaunogona kutarisira. Iwe unofanirwa kuva ruzivo nezvemishonga yakasiyana-siyana yeArthritis, kuitira kuti iwe unogona kuita chisarudzo chakanaka nechiremba wako.
NSAIDs / COX-2 Inhibitors
NSAIDs (nonsteroidal anti-inflammatory drugs) ndeyedzimwe inowanzotaurwa uye inoshandiswa zvakanyanya kushandisa arthritis drugs. Kune mhando mitatu yeNSAIDs: salicylates (zvose zvakagadziriswa [semuenzaniso, aspirin] uye isina-acetylated [semuenzaniso, Disalcid {salsalate}]), Chengeta (choline magnesium trisalicylate), uye Doan's Pills kana Novasal (magnesium salicylate); iyo NSAID dzetsika; uye COX-2 selective inhibitors.
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Kushandisa Masero eStem Kurapa Arthritis uye Cartilage Damage
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JAK Inhibitors: A Treatment Option yeRheumatoid Arthritis
NSAIDs inoshanda nekuvhara basa re enzyme, cyclooxygenase, inozivikanwawo seCCOX. Kutsvakurudza kwakaratidza kuti kune maitiro maviri e cyclooxygenase, inozivikanwa seC CO-1 uye COX-2 . NSAIDs inobata zvose mafomu. COX-1 inobatanidzwa mukuchengetedza mishonga yakagadzikana, apo COX-2 inobatanidzwa mukuputika kwenzira. COX-2 sarudzo inhibitors yakava nhengo yeNSAIDs- neCelebrex (celecoxib) kuva yekutanga kuva FDA-yakagumira kuma1900.
NASIDZO dzeChechi dzinosanganisira:
- Ansaid (flurbiprofen)
- Arthrotec (diclofenac / misoprostol)
- Cataflam (diclofenac potassium)
- Clinoril (sulindac)
- Daypro (oxaprozin)
- Dolobid (diflunisal)
- Feldene (piroxicam)
- Ibuprofen (mutengo Motrin, Advil)
- Indocin (indomethacin)
- Ketoprofen (zita rinonzi Orudis, Oruvail)
- Lodine (etodolac)
- Meclomen (meclofenamate)
- Mobic (meloxicam)
- Nalfon (fenoprofen)
- Naproxen (mureza Naprosyn, Aleve)
- Ponstel (mefenamic acid)
- Relafen (nabumetone)
- Tolectin (tolmetin)
- Vimovo (naproxen-esomeprazole)
- Voltaren (diclofenac sodium)
COX-2 Inhibitors inosanganisira:
- Celebrex (celecoxib)
Verenga: NSAIDs - Zvaunofanira Kuziva
DMARDs
DMARDs (chirwere-chinorwisa anti-rheumatic drugs) chinonziwo "inononoka-kuita anti-rheumatic drugs" nokuti inowanzoita mavhiki kana mwedzi kushanda uye "wechipiri-line agents". Kutsvakurudza kwakasimbisa kubudirira kweDMARD mukurapa rheumatoid arthritis , psoriatic arthritis , uye ankylosing spondylitis pamwe nekukosha kwekutanga, kushungurudza kushandiswa uchishandisa DMARD. Chinangwa chekurapwa neDMARD ndechekudzivisa kuwedzera kwezvirwere uye kumisa kukanganisa pamwe.
DMARD inosanganisira:
- Azulfidine (sulfasalazine)
- CellCept (mycophenolate)
- Cyclosporine (zita reNeoral, Sandimmune)
- Cytoxan (cyclophosphamide)
- Imuran (azathioprine)
- Leukeran (chlorambucil)
- Methotrexate (zita reRheumatrex, Trexall)
- Minocin (minocycline)
- Penicillamine (brand Cuprimine, Depen)
- Plaquenil (hydroxychloroquine)
Xeljanz (tofacitinib citrate), yemuromo DMARD, yakagamuchirwa neDFA musi waNovember 6, 2012, kuti iite vanhu vakuru nekuita zvakanyanyisa kurwisa zvakanyanya rheumatoid arthritis avo vasina kukwana kusateerera, kana kusawirirana, kuti vaite methotrexate. Xeljanz ndiye wokutanga mukirasi yemishonga inonzi JAK (Janus kinase) inhibitors.
Verenga: Chokwadi Pamusoro peDMARD
Corticosteroids (Steroids)
Corticosteroids kana glucocorticoids, inowanzonzi "steroids," ndiyo inodhaka mishonga inogona kuderedza kuzvimba nekuputika nokukurumidza. Iyi mishonga inobatana zvakanyanya ne cortisol, hormone inogadzirwa ne cortex yeadrenal glands. Izvo zvinorayirwa mune zvakasiyana-siyana zvakasiyana-siyana zvichienderana nemamiriro uye chinangwa chekurapa. Kunyange zvazvo steroid inogona kushandiswa kudzora kuvhiringidza kwezvibatanidzwa uye nhengo muzvirwere zvinoputika, zvakadai se rheumatoid arthritis, lupus , polymyalgia rheumatica , uye vasculitis , yakagadzirirwa kuti zvinogona kukonzerwa nemigumisiro yakakomba inowedzera pamvura yakakura kana kwenguva refu shandisa.
Vanachiremba vanogona kupa nguva shomanana, yakakwirira-intravenous steroid mune dzimwe mamiriro ezvinhu, kana chiremba wako anogona kutora seniid inokwaniswa munzvimbo yakasiyana, yakadai seKenalog (triamcinolone), kuti ikubatsire kuwana zororo kubva pakurwadziwa nekuputika.
Corticosteroids inosanganisira:
- betamethasone (mutengo Celestone)
- cortisone (chinonzi Cortone)
- dexamethasone (chiratidzo Decadron)
- hydrocortisone (brand Cortef)
- methylprednisolone (brand Medrol )
- prednisolone (brand Prelone)
- prednisone (maruva Deltasone)
Verenga: Corticosteroids (Steroids) - Zvaunofanira Kuziva
Analgesics (Pain Medications)
Analgesics inorwadza-kuremesa zvinodhaka. Kudzora kurwadziwa chikamu chinokosha pakurapa arthritis. Zvisinei, kusiyana neNSAIDs, mishonga yekurapa haina kubvisa kutuka. Acetaminophen (Tylenol) ndiyo inonyanya kushandiswa kuenzaniswa. Dhacotic analgesic zvinodhaka zvinogonawo kurongerwa kunorwadza kwakanyanya.
Narcotics inosanganisira:
- Codeine (Tylenol # 3)
- Duragesic (Fentanyl Skin Patch)
- Hydromorphone (Palladone) - haisisiri pamusika
- MS Contin (morphine sulfate)
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Hydrocodone / Acetaminophen - Zvaunofanira Kuziva
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Mazano Kune Vanhu Vasina Matambudziko Kuchera Mapiritsi
- OxyContin (oxycodone)
- Percocet (oxycodone / acetaminophen)
- Percodan (oxycodone / aspirin)
- Talwin NX (pentazocine / naloxone)
- Ultracet (tramadol / acetaminophen)
- Ultram (tramadol)
- Vicodin (hydrocodone / acetaminophen)
Verenga: Analgesic Mishonga - Zvaunofanira Kuziva
Biologic Response Modifiers (Biologics)
Zvinonzi Biologic Response Modifiers (BRMs), zvinowanzozivikanwa sebiologics , zvinokurudzira kana kudzorera kukwanisa kwezvirwere zvekudzivirira zvirwere kana kurwara. Biologics imishonga inotorwa kubva mumhepo inorarama asi inopesana nekugadzirwa kwemakemikari.
Enbrel (etanercept) , Remicade infliximab) , Humira (adalimumab) , Cimzia (certolizumab pegol) , uye Simponi (golimumab) chinangwa TNF-alpha, chimwe chezvinhu zvakakosha zvikuru zvektokine zvinosanganisira rheumatoid arthritis. TNF blockers (biologic zvinodhaka zvinosunga kuna TNF-alpha) dzinoita kuti zvirege kushanda, nokudaro zvinopindira kuita basa rekuvhiringidza uye pakupedzisira kuderedza kuwirirana pamwe.
Kineret (anakinra), uyewo chirwere chebiologic, ndiye anopikisa IL-1. Kineret ndiyo yaiva yekutanga yechinyorwa ye interleukin-1 (IL-1), puroteni inowanikwa muhuwandu mune vamwe vanhu vane rheumatoid arthritis. Nokudzivirira IL-1, Kineret inhibits kupisa uye kurwadziwa kunobatanidza nerheumatoid arthritis. Kineret inogona kushandiswa yoga, kana inosanganiswa nedzimwe DMARD, kunze kwemishonga inorwisa-TNF. Kunyange zvazvo Kineret isarudzo, inowanzosarudzwa.
Orencia (abatacept) ndiye wekutanga T-cell co-stimulation modulator kuti agamuchirwe kurapa rheumatoid arthritis.
Rituxan (rituximab) , mishonga yemukenza yakatengesa zvikuru, iyo FDA yakagamuchirwa munaMarch 2006 kuti ishandiswe pamwe ne methotrexate kuti iite rheumatoid arthritis nekuderedza zviratidzo nezviratidzo kune vanhu vakuru vane maitiro anonyanya kuoma rheumatoid arthritis uye vane vakundikana rimwe kana zvinopfuura zvinorwisa-TNF zvinodhaka. Rituxan ndiyo yekutanga kurapwa kwerheumatoid arthritis iyo inosarudzira ma CD20-positive B-seli.
Actemra (tocilizumab) inonzi antioclonal antibody inhibits the interleukin-6 (IL-6) receptor, nokudaro inodzivirira interleukin-6. Actemra yakagamuchirwa neDFA paJan 8, 2010 pakurapwa kwevanhu vakuru vane rheumatoid arthritis kune vanhu vakakundikana imwe kana kupfuura TNF blockers.
Rheumatoid Arthritis Treatment - ACR Mazano
Fibromyalgia Zvinodhaka
Kusvikira muna 2007, pakange pasina mishonga inobvumidzwa neDDA yekurapa fibromyalgia . Vanachiremba vakabata fibromyalgia nemhando dzakasiyana-siyana zvezvinodhaka zvakagadzirwa uye zvinogamuchirwa kune zvimwe zviratidzo. Muna 2007, Lyrica (pregabalin) akagamuchirwa kutora fibromyalgia. Muna 2008, Cymbalta (duloxetine HCl) yakagamuchirwa kwe fibromyalgia. Muna 2009, Savella (milnacipran HCl) yakagamuchirwa pamamiriro acho ezvinhu.
Gout Zvinodhaka
Gout ndechimwe chezvinhu zvinorwadza zvikuru zveArthritis. Inogona kutarisirwa nemishonga, kudya, uye mararamiro ehupenyu. Pane zvikamu zvitatu zvekurapwa kwemishonga nemishonga: analgesics, anti-inflammatory mishonga, nemishonga yekuita uric acid mazinga uye gout kushorwa .
Zvinodhaka zve gout zvinosanganisira:
- Acetaminophen (Tylenol), kana zvimwe zvipembenene zvinokonzera marwadzo, nokuda kwekunzwa kurwadziwa
- NSAIDs (nonsteroidal anti-inflammatory drugs), kazhinji Indocin (indomethacin), nokuda kwokuputika
- Colchicine , kudzivirira kana kubvisa gout kushorwa
- Corticosteroids, nokuda kwekurumidza kupesana nekuputira mhinduro
- Probenecid (Benemid, Probalan), kuderedza uric acid ropa
- ColBenemid (Col-Probenecid naProben-C) ine anti-gout
- Allopurinol (zyloprim) , kuderedza ropa uric acid nekudzivirira uric acid kugadzirwa
- Losartan (Cozaar, Hyzaar), kwete kunyanya mishonga yegout, asi iri mishonga inopesana nehutachiona iyo inogona kubatsira kudzora uric acid mazinga
- Fenofibrate (Tricor), kwete chirwere chinonzi gout, asi chirwere chinoderedza-mishonga chinogona kubatsira uric acid mazinga
- Uloric (febuxostat) , inoderedza serum uric acid mazinga nekuvhara xanthine oxidase
- Krystexxa (pegloticase), chirwere chebiologic chinoshanda nekuputsa uric acid
Osteoporosis Zvinodhaka
Osteoporosis ndiyo inoratidzwa nemapfupa ane mapundu, ane brittle, anonyanya kufanana kune vakwegura, asiwo anogona kunge akaoma kune vanhu vakatora corticosteroids (steroids) longterm. Kune zvikamu zvakasiyana zvezvikwata zvinoshandiswa nemishonga ye osteoporosis: estrogens, hormone dzepathyroid, bone mapurisa, bisphosphonates, uye senyuchi zvinogamuchirwa. Zvichienderana nemishonga ipi inoshandiswa, unogona kuderedza kurasikirwa kwemapfupa, kukurudzira kufema kwemafupa, uye kuderedza ngozi yezvakawanda.
Zvinodhaka zvehutachiona zvinosanganisira:
- Actonel (risedronate)
- Boniva (ibandronate)
- Didronel (etidronate)
- Estrogens (hormone therapy)
- Evista (raloxifene)
- Forteo (teriparatide)
- Fosamax (alendronate)
- Miacalcin (calcitonin)
- Reclast (zoledronic acid)
- Prolia (denosumab)
Shoko Rinobva
Zvinangwa zvekurapa chirwere cheArthritis uye zvirwere zveRheumatic nemishonga zvinosanganisira kudzora marwadzo, kuderera kuputika, kunonoka kufambira mberi kwechirwere, nekugadzirisa zvirwere zvekuita. Kune mhando dzakawanda dzeArthritis uye nemishonga yakawanda mune rimwe boka remishonga. Izvo zvinoita kuti kusarudza reguropi zvinyorwa zvakaoma. Kusarudza kuti mishonga kana kusanganiswa kwemishonga yakakosha sei iwe inogona kunge inotyisa. Zvichida zvichatora kuedza uye kukanganisa-uye iwe ucharamba uchiedza kusvikira iwe uchinzwa kuti wapedza mhinduro yakakwana. Verywell yakanyora chokwadi chaunoda kuziva nezvemishonga yeArthritis. Mashoko aya akapiwa achakubatsira kunzwisisa kuti sei uri kutora mishonga iwe uri kutora uye ichakubatsira iwe kuumba mibvunzo kune chiremba wako.
> Kwakabva:
> Kelley's Textbook of Rheumatology. Chikamu 8. Pharmacology yeAnterrheumatic Drugs. Elsevier. Ninth edition. Yakasvika 07/23/16.