FAQs About About Rheumatoid Arthritis Zvinodhaka
TNF inhibitors mishonga yekurapa rheumatoid arthritis. Sezvakaita chero mishonga ipi zvayo, inogona kuva yakakosha kune vamwe vanhu uye zvishoma kune vamwe. Hezvino tarisiro yeiyo TNF inhibitors uye kuti inoshanda sei, izvo zvingave nemigumisiro yei, uye kuti yakajeka sei inofananidzwa.
Chii chinonzi TNF inhibitors?
TNF inhibitors dzakanyanyisa, zvinodhaka zvinodhaka zviri mukirasi yemishonga inonzi biologics.
Vanoshanda nekutsvaga chinhu chinonzi tumor necrosis chinokonzera kupisa. Dzimwe biologics dzekurapa rheumatoid arthritis ndeyomuviri muto.
Biologics imishonga inotarisa mamolekemu anokonzera kuvhiringidza uye majoini anokanganisa. Vanowanzomirirwa kune vanhu vari kutora mamwe marudzi emishonga yeArthritis, yakadai seDMARDs (chirwere chinoshandura anti-rheumatic drugs), asi kwete kuwana zororo rakakwana.
Chii Chinonzi Tumor Necrosis Factor?
Tumor Necrosis Factor ipuroteni yakagadzirwa nemusununguko wemuviri. Inobatanidzwa mune zvimwe zvakakosha zvemuviri wemabasa, zvakadai semafuta metabolism uye coagulation, kana kuvhara, kwemasero eropa. Mimwe mamiriro ezvinhu, kusanganisira chirwere uye zvirwere zvinotapukira semunhu zvakadai se rheumatoid arthritis, zvinogona kukonzera kupererwa kweTFF, iyo inotungamirira kukuvhiringidza.
Chii Chinonzi Monoclonal Antibody?
Iwe unotoziva kuti ma antibodies zvinhu zvinokonzerwa nemajoni ehurumende kuti varwise antigens zvakadai semavirusi.
Monoclonal antibodies inobudiswa murabhu uye yakagadzirirwa kutsvaga ma molecules, akadai seTNF.
Kuenzanisa TNF Inhibitors
Nguva dzose zvakakosha kutarisa kufanana nekusiyana pakati pemishonga apo iwe uye chiremba wako uri kutarisa pane kurapwa kwakakunakira iwe. Zvimwe zvinhu zvinofanira kuonekwa kana ukasarudza pakati peTNF blockers ndezvokuti mumwe nomumwe anopiwa sei, migumisiro, uye mari.
Enbrel (etanercept) yaiva yekutanga anti-TNF mishonga. Yakagamuchirwa neU.S. Food and Drug Administration (FDA) muna 1998. Enbrel inotorwa nekuisa DNA yevanhu muchiChinese hamster ovary masero kuti aumbe mapuroteni anogadzirwa nemajini.
Remicade (infliximab) inonzi antioclonal antibody inosungira uye inodzivirira tumor necrosis chinonzi alpha (TNF-alpha). Yaiva yechipiri TNF inhibitor kuva FDA-yakagamuchirwa, muna 1999.
Humira (adalimumab) is "humanized fully" monoclonal antibody, zvinoreva kuti maitiro chaiwo emishonga akafanana neaya evanhu vanorwisa, kunyange zvazvo yakasikwa mubasa. Humira yakagamuchirwa neCDA muna 2002.
Cimzia
Cimzia (certolizumab pegol) ndiyo chete inonzi TNF inhibitor inobata kusava neuturu kumasero nekuda kwemakemikari ayo. Mukuwedzera, achienzaniswa nedzimwe mishonga inorwisa-TNF, Cimzia yakarondedzerwa ine hukama hwepamusoro hwe TNF yevanhu.
Simponi
Simponi (golimumab) inonzi TNF-alpha blocker iyo inorayirwawo kuti uite chirwere chepachirwere, psoriatic arthritis, uye ankylosing spondylitis. Yakabvumirwa muna 2004.
Mitezo Yechiratidzo yeNADF Blockers
Hapana mishonga isina michero. Zvimwe zvinetso zvinogona kuwirirana neNADF blockers zvinonyatsozivikanwa, zvichiita kuti vamwe varwere vemaArthritis vave nehanya nekutora TNF inhibitors .
Asi kune vanhu vakawanda, zvikomborero zvakanyanya kupfuura zvengozi.
Vamwe varwere vanowanzosangana nehutachiona apo vachirapwa neDMARD kana biologic zvinodhaka. (Ndizvo zvakafanana neDMARDs.)
Chidzidzo che 2016 chakawana kuti vanhu vakatora dzimwe nhengo dzeNATF dze rheumatoid arthritis vaiwana katatu dambudziko rekuwedzera dzimwe kenza, dzakadai se lymphoma. Izvi zvaive chokwadi chaiyo dai vakanga vachikwirira.
Verenga Zvose Nezvazvo
Arthritis Pasina Uturu - Chishamiso cheNADF Blockers
Bhuku iri neRheumatologist Scott J. Zashin, MD, rinotsanangura kuti TNF inogadzirisa sei uye inofananidzwa sei nedzimwe mishonga yeArthritis.
Anosanganisira kugadzirisa nyaya dzekutsungirira uye anoenderera mberi kuti izvi zvidzidzo zvekiradhi zvakashandura sei upenyu.