NSAIDs Ndidzo Pakati Pezvinonyanya Kuzivikanwa Arthritis Zvinodhaka
NSAIDs (nonsteroidal anti-inflammatory drugs) kurwisa arthritis kuburikidza nekupindira nekuputira chirongwa. NSAIDs boka guru remishonga inowanzoshandiswa kurapa arthritis nekuda kweiyo:
- analgesic (kurwadzisa-kurwadza)
- anti-inflammatory properties
- antipyretic (fever-reducing) properties
NSAID Zvitsva
Kune marudzi matatu eNSAIDs:
- salicylates (zvose acetylated, zvakadai sa aspirin , uye dzisina kukwana)
- tsika dzeNSAID
- COX-2 selective inhibitors
NSAID dzinowanzoshandiswa muArthritis dzinosanganisira:
- Ansaid (zita rinowanzoreva flurbiprofen)
- Arthrotec (zita rinowanzoitwa diclofenac ne misoprostol)
- Aspirin (acetylsalicylic acid)
- Cataflam (zita rinowanzoitwa diclofenac potassium)
- Celebrex (zita rinonzi celecoxib)
- Clinoril (zita rekuti sulindac)
- Daypro (zita rinonzi oxaprozin)
- Disalcid (zita rinoreva salsalate)
- Dolobid (zita rinoreva diflunisal)
- Feldene (zita rechipiri piroxicam)
- Ibuprofen (mazita emagetsi anosanganisira Motrin, Advil, Mediprin, Nuprin, Motrin IB)
- Indocin (zita rechiito indomethacin)
- Ketoprofen (mazita emagetsi anosanganisira Orudis, Oruvail, Actron, Orudis KT)
- Lodine (zita rechiito rokuti etodolac)
- Meclomen (zita rinowanzoreva meclofenamate sodium)
- Mobic (zita rinoreva zita rokuti meloxicam)
- Nalfon (zita rinowanzoreva fenoprofen)
- Naproxen (mazita emagetsi anosanganisira Naprosyn, Aleve, Naprelan, Anaprox)
- Ponstel (zita rinowanzoreva mefenamic acid)
- Relafen (zita guru rinonzi nabumetone)
- Tolectin (zita rechiito rokuti tolmetin sodium)
- Tora (zita rinowanzoreva choline magnesium trisalicylate)
- Voltaren (zita rinowanzoitwa diclofenac sodium)
Nzira dzeNSAID dzinoshanda sei
Nemashoko akajeka, NSAIDs inoshanda kuburikidza nekuderedza kuputika. Vanoita izvi nekuvhara enzyme inokosha yekuputika inonzi cyclooxygenase, iyo inoshandura arachidonic acid kune prostaglandin uye leukotrienes.
Prostaglandins inokonzera kupopota kwemukati. Nokudaro, nekudzivisa cyclooxygenase, NSAIDs dzinoderedza kupisa .
Imwe NSAID inogona kukubatsira zviri nani kupfuura iwe wawaedza kare - kana kuti isingashande zvachose. Izvi zvinokonzerwa nechimwe chinhu chinonzi pharmacokinetic kusiyana-iyo nzira iyo mushonga inowanikwa, inoparadzirwa, inogadziriswa, uye inopedzwa.
Zvimwe pane Enzyme Cyclooxygenase
Kune miviri miviri ye cyclooxygenase, inonzi COX-1 uye COX-2. COX-1 inobatanidzwa mukuchengetedza utano hwakanaka uye utano hwepso. COX-2 ndiyo enzyme inokonzerwa nokuputika. Nemhaka yokuti NSAID dzetsika dzinovhara zvose COX-1 ne COX-2, dzinogona kuva nemigumisiro isingadiwi, yakadai sekutsamwa kwepamuviri kana kupera kwepfungwa. Ndokusaka vatsvakurudzi vakagadzira NSAIDS iyo inodzivisa COX-2 chete. Iwayi COX-2 selective inhibitors ndiyo boka idzva reNSAIDs.
Dhiyabhorosi Zviito zveNSAID dzose
Muna 2004, muumbi we COX-2 selective inhibitor Vioxx nokuzvidira akabvisa kubva pamusika pashure pokunge zvidzidzo zvakaratidza kushandiswa kwenguva refu zvinogona kuwedzera njodzi yekurwadziwa kwepfungwa uye kurohwa. Kuongororwa kunotevera kweUnited States Kudya uye Drug Administration kwakatungamirira kusvika muna 2005 zvido zvekuti zvose zvinonzi non-aspirin NSAIDs zvinotanga kunyevera.
Zvakakosha kukurukura izvi zvinogona kuisa njodzi kune chiremba wako. (Izvo zvakasara zvakasiya imwechete COX-2 inhibitor pamusika - Celebrex.)
Kubudirira kweNSAIDs
- Urombo uye kuputika dzimwe nguva zvinowanzoitika munharaunda ye circadian (zuva rhythmic cycle zvichienderana nenguva yeawa 24). Nokudaro, NSAIDs inogona kuva yakakwanisa pane dzimwe nguva.
- Vanenge makumi matanhatu kubva muzana vevarwere vachabvuma kune imwe NSAID imwechete. Nguva yekuedzwa kwevhiki nhatu inofanira kukubvumira nguva yakakwana yekuziva kana mushonga uri kukushandira iwe. Zvinosuruvarisa, zvinenge gumi kubva muzana zverheumatoid arthritis varwere vachawana NSAIDs hadzingashandi kwavari.
- NSAIDs inogona kuvhara zviratidzo nezviratidzo zvehutachiona.
- Zvakaipa zvinokonzerwa neNSAID zvinogona kuitika panguva chero ipi zvayo dzinosanganisira kushaya kwetsvo, kushaya chiropa, kubuda ropa, uye gastric (mudumbu) kuonda.
- NSAIDs (kunyanya indomethacin) inogona kupindira nemishonga inoshandiswa kudzora kukwirira kweropa uye kukanganisa kwemwoyo (zvakadai se beta-adrenergic antagonists, angiotensin-kuchinja enzyme inhibitors, kana kuti diuretics).
- Dzimwe tsvakurudzo dzinotsvakurudza dzinoti nguva refu inoshandiswa NSAID inogona kukurumidzira kuwirirana kwekasitilage kurasikirwa, asi kumwe kuongorora kunodiwa.
The Bottom Line
Haikwanise kutaurirwa kuti NSAID ichakushandirai nani. Hapana NSAID imwechete yakaratidzwa kuva yakakwirira kupfuura vamwe kuti vatsigire kurwadziwa. Pane imwe nguva NSAID inosarudzwa, muyero inofanira kuwedzerwa kusvikira marwadzo asunungurwa kana kusvikira mazamu akarerukirwa akawanikwa. Mhinduro yevarwere inofanira kuva nhungamiro yekusarudza mubairo wakakodzera, uchishandisa muchero wakaderera zvikuru unogona kuwana kuponeswa kunorwadza. Nguva dzose kurukura nezvekubatsira uye njodzi dzinogona kuitika dzeNSAID nechiremba wako.
> Sources:
> Duke University Medical Centre Bhuku reArthritis, David S. Pisetsky, MD, Ph.D. 1995.
> New England Journal of Medicine, 324 (24): 1716-1725, 1991