Remicade Imishonga Inoshandiswa Kugarisa Zvirwere zveCrohn Uye Ulcerative Colitis
Remicade (infliximab) rudzi rwechirwere chinodanwa se monoclonal antibody. TNF-alpha (tumor necrosis factor alpha) inowanikwa muhuwandu hwakawanda kune vanhu vane chirwere cheCrohn kupfuura kune vanhu vasina chirwere chipi nechipi chechirwere chinokonzera zvirwere (IBD) . Remicade inomira TNF-alpha kubva pakushandiswa nemuviri.
TNF-alpha inongova cytokine iyo inobatanidzwa mukugwinya kwemuviri mumuviri.
IBD chirwere chekuvhiringidza, uye TNF-alpha inofungidzirwa kuti inobatsira nenzira iyo IBD inokanganisa maitiro emimba. Inonzi cytokine inoenda pakati pemasero mumuviri anounza makemikari "mharidzo."
Sei Kudzokorora Kunotorwa?
Remicade inopiwa sechidimbu kuburikidza ne-IV line, kazhinji muchipatara kana kuhofisi yechiremba. Iko kunokonzerwa kunopiwa zvishoma nezvishoma pane zvishoma (kazhinji 2 mamwezve maawa). Chiremba anotsanangura Remicade achapa chero mirayiridzo inokosha iyo varwere vanofanira kutevera musati wasarudzwa kusanganiswa.
Sei Kutaridzirwa Kudzorerwa?
Remicade inogona kunyoreswa kune iyo miviri mikuru yeBD: inononoka kusvika yakakomba chironda chetachiona kana chirwere cheCrohn. Remicade inobvumidzwawo kuti ishandiswe muvana vanopfuura makore matanhatu avo vane chirwere chakakomba kusvika kuCrohn's or modate to severe ulcerative colitis iyo haisi kupindura kune dzimwe mishonga yemishonga. Inogonawo kugoverwa kune vanhu vane Crohn's disease vane fistulas uye vanobata mamwe maitiro ehurmatoid arthritis .
Remicade zvisungo kune TNF-alpha, kuzvidzivirira kubva pakukonzera kupisa mumuviri. Ne TNF-alpha isingagoni kukonzera kutuka, munhu ane IBD angasangana nenguva isingashandi muhutano hwehutano, zvakare inonzi kuregererwa .
Ndiani Asingafaniri Kuitora?
Taurira chiremba wako kana iwe wakambove nechimwe chezvinhu zvinotevera:
- Allergic reactions kune chero mishonga
- Current pregnancy
- Cancer
- Zvirwere
- Lupus
- Kurwisa mutsva
Zvichida Zvimwe Maitiro
Matambudziko anowanzoitwa Remicade anosanganisira kurwadziwa kwepamuviri, kusuruvara, kuneta uye kurutsa. Udza chiremba wako kana kune zvimwe zvinokonzera kushungurudza kana kusaenda.
Kazhinji zvimwe, zvinokonzerwa nemigumisiro yakaipa inogona kuitika, zvakadai sokuoma kunyorera, utachiona, kusagadzikana kwepfungwa uye kurwadziwa kwepakadzika. Iyi migumisiro yemigumisiro inofanira kuudzwa kunechiremba wako pakarepo. Ona Remicade yemigumisiro yemigumisiro yezveruzhinji rwakakwana rwekukanganisa kusingaiti.
Mishonga Inopindirana
Remicade haina kumbove yakanyatsodzidza nezvekubatana kwezvinodhaka. Munguva yezvipatara miedzo yeRicicade, vamwe varwere vakanga vatotora ma antibiotics, mavativirals, corticosteroids (akadai prednisone), 6-MP / AZA uye aminosalicylates. Ava varwere havana kuwana huwandu hwakawanda hwekuvhiringidza kwevamwe sevaya vasina kutora chero mimwe mishonga.
Zvisinei, vanhu vanogamuchira Remicade havafaniri kugamuchira chero mishonga ine mavairasi anorarama kana mabhakitiriya (iyo nguva yefenza inopisa haina mishonga inorarama). Remicade inodzvinyirira zvirwere zvemuviri, uye kutora mamwe mishonga inodzivisa maitiro ezvirwere mumuviri panguva imwechete inogona kuwedzera ngozi inogona kuitika yehutachiona.
Chiremba anofanira kubvunzurudzwa nezvemumwe mimwe mishonga inotorwa panguva imwe chete neRicicade.
Food Interactions
Hakuchina kushamwaridzana kwekudya kunozivikanwa.
Inogadziriswa Yakachengeteka Panguva Yechirwere Here?
Iyo FDA yakaronga Remicade sechirongwa cheB B. Mhedzisiro yaRicicade kune mwana asati aberekwa haana kumbobvunzwa zvakanyanyisa. Remicade inofanira kungoshandiswa chete panguva yekuzvitakura kana ichidikanwa. Zivisai kududzira chiremba kana iwe ukava nepamuviri paunotora Remicade. Zvinofungidzirwa kuti Remicade haifaniri kupinda mumukaka wemvere. Vakadzi vanofanira kutarisana navanachiremba, asi iye zvino vanofunga kuti vakadzi vari kugamuchira Remicade havafaniri kuora mwoyo kubva mukuyamwisa vana vavo, zvikurukuru vachipa zvikomborero zvakapararira zvemukaka wemucheche kwechecheche.
Ndingawana sei rubatsiro rwezvinodiwa?
Janssen Pharmaceuticals ine Patient Assistance Program kuti ibatsire kuwana rubatsiro rwezvechiremba Remicade. Rubatsiro runogona kuwanikwawo kubva kumabhizimusi emunharaunda.
Sources:
Kane S, Ford J, Cohen R, Wagner C. "Kusana kwe infliximab mucheche uye mukaka wemukaka kubva kuvakadzi vanoyamwisa vanowana kurapwa kwechirwere cheCrohn vasati vasvika." J Clinic Gastroenterol. 2009 Aug; 43: 613-616.
Remicade.com. "Zvaunoda Kuziva Nezve Remicade." Janssen Pharmaceuticals. 28 Jan 2016.
> Wilhelm SM, McKenney KA, Rivait KN, Kale-Pradhan PB. "Kuongororwa kwepineximab inoshandiswa muhutachi inouraya." Clin Ther . 2008 Feb; 30: 223-230.