Kurapa Option yeFibromyalgia
Musi waJanuary 14, 2009, FDA yakabvumira Savella (milnacipran HCl) yekutungamirira fibromyalgia . Savella inorondedzerwa serotononin uye norepinephrine dual reuptake inhibitor. Mushonga uyu wakashandiswa kwemakore anoverengeka muEurope neAsia kuti uite chirwere.
Chii Chinonzi Serotonin Yokusarudza uye Norepinephrine Dual Reuptake Inhibitor?
Sezvo serotonin yakasarudzwa uye norepinephrine inonzi reuptake inhibitor, inozivikanwawo seSSNRI, Savella inowedzera norepinephrine uye basa re serotonin muuropi.
Muchikamu chekuedza, Savella inoratidzika kuva nemigumisiro yakawanda pane norepinephrine basa. Izvi zvakakosha kuvarwere ve fibromyalgia nokuti uropi hwakadzika norepinephrine maitiro hunofanirwa kunge hwakabatana nekurwadziwa nekuwedzera kwezvinetso ("brain fog").
Sei Savella Anopiwa?
Savella inotarisirwa muzvikamu zviviri zvakaparadzaniswa pazuva. Nhamba yacho inowedzerwa zvishoma nezvishoma pamusana wevhiki yekutanga kusvika kune imwe yenhamba yakakurudzirwa ye 100 mg / zuva.
Savella inowanikwa se 12.5 mg, 25 mg, 50 mg, uye mapiritsi 100 mg. Pazuva 1, iwe unotora 12.5 mg kamwechete. Pazuva 2 kusvika ku3, iwe unotora 12,5 mg / kaviri pazuva. Pazuva 4 kusvika ku7, unotora 25 mg / kaviri zuva rimwe nerimwe. Mushure mezuva 7, chirwere chinowanzoitwa 50 mg / kaviri zuva rimwe nerimwe. Vamwe varwere vangada 200 mg / zuva - uye vamwe vangada mubairo wakaderera kana vane renal (kidzo) kuora mwoyo.
Ko Savella Akaitwa Sei Muzvipatara Miedzo?
Kuchengetedzwa uye kubudirira kwaSavella kwakagadzirirwa kubva pamigumisiro yechikamu chechipiri mishonga yemakirini muUnited States Pane varwi vanopfuura 2 000 vane fibromyalgia vanobatanidzwa mune zvidzidzo.
Contraindications for Savella
Savella inopikiswa (haifaniri kushandiswa) kune varwere vasina kutongororwa mashoma-angle glaucoma. Savella haafaniriwo kushandiswa nevarwere vanotora MAOIs (monoamine oxidase inhibitors), inowanzoshandiswa kuora mwoyo. Savella haibvumirwi kushandiswa muvana.
Manyevero Akabatanidzwa naVa Savella
Varwere vanorayirwa Savella vanofanira kuziva nezvekuteverwa nekudzivirira:
- Kuwedzera kuora mwoyo zviratidzo uye ngozi yekuzviuraya zvinogoneka na Savella
- Serotonin syndrome (chirwere chinopisa upenyu chemishonga chinokonzera kuti muviri uve neserotonin yakawanda) inogoneka.
- Kuwedzera kweropa rega uye kutengesa kwemoyo kunogona kuitika na Savella.
- Kushungurudzwa kwakave kwakataurwa kune varwere vanotora Savella.
- Hepatotoxicity yakambotaurwa (varwere vane doro rinodhaka kana kushandisa chirwere chechirwere chisingaperi chingafanira kuchengetedza Savella).
- Kurega zviratidzo zvinogona kuitika kana Savella asina kubviswa zvishoma nezvishoma.
- Savella inogona kuwedzera dambudziko rekubuda ropa kunyanya kune varwere vanotora NSAIDs , aspirin , kana zvimwe zvinodhaka zvinokonzera kubuda ropa.
- Ikoko kunogona kuva nezvikwata zvakakwirira zvezviitiko zvekuberekwa kwegenitourine uye Savella kushandisa.
Savella yakasarudzwa seMubatanidzwa C C agent, zvinoreva maitiro akanaka emuchechi ekudzidzira mhuka. Muumbi we Savella anotaura kuti hapana zvidzidzo zvakakwana kana zvakanyatsorongedzwa zvakataurwa kune vakadzi vane pamuviri, naizvozvo inofanira kushandiswa panguva yekuzvitakura chete kana zvinogona kubatsira zvinokonzera njodzi dzinogona kuitika kumucheche.
Zvidzidzo zvakarongedzwa zveSapella hazvina kuitwa pamadzimai ekuyamwisa.
Maitiro Anowirirana Nezviitiko uye Zvakaipa Zviitiko
Nausea, kurwadziwa musoro, kuvimbwa, ucheche, kusuruvara, kuputika, kuwedzera kufema, kurutsa, kutapira, uye muromo wakaoma kusangana kwakaipa kunobatanidza Savella.
Sources:
Savella Prescribing Information. Savella.com. 01/08/2009.
http://www.allergan.com/assets/pdf/savella_pi
Milnacipran (Savella), Treatment Option yeFibromyalgia. P & T (Pharmacy & Therapeutics) P T. 2010 May; 35 (5): 261-266.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873711/