Zvirwere-Kuchinja Maitiro Anorwisa Dheumatic Drug for Arthritis
Sulfasalazine (zita rinonzi Azulfidine) chirwere chakange chiripo kune makore anenge 60, asi kushandiswa kwayo kunowedzera mukati memakore makumi maviri apfuura. Zvaiita sokuti zvinorasikirwa nekuzivikanwa kwakawanda sezvinonzi biologic zvinodhaka zvakatanga kutengeswa muna 1998 nezverheumatoid arthritis . Zvinoratidzika kunge zvichiita kudzoka kwevarwere vasingagoni kushivirira methotrexate kana kuti avo vasina kukodzera vanosarudza biologic zvinodhaka.
Kirasi yeMishonga
Sulfasalazine, sezvaungangopokana nayo kubva kune zita racho, ndeyekirasi yemishonga inonzi sulfa zvinodhaka. Sulfasalazine ine salicylate uye sulfa antibiotic. Sulfasalazine inorondedzerwa seDMARD (chirwere-chinorwisa anti-rheumatic drug).
Zviratidzo zveKushandiswa kweSulfasalazine
Kunze kwekushandiswa kwaro semushonga we rheumatoid arthritis, sulfasalazine inotarisirwawo nevana vechirwere , psoriatic arthritis , ankylosing spondylitis , uye ulcerative colitis.
Sulfasalazine inobatsira kuderedza marwadzo, kuzvimba, uye kuoma kwakabatana neArthritis. Inonyanya kubudirira pakurapa zviratidzo zvishoma kusvika pakuenzanisa. Sulfasalazine zvakare inogona kudzivirira kuwirirana pamwe uye kuderedza dambudziko rekubata pamwe kwebasa. Kazhinji, varwere vanopindura sulfasalazine vanocherechedza kubudirira mukati memavhiki gumi nemaviri.
Mashoko Okusarudza uye Kuwanikwa
Sulfasalazine inowanikwa sehwendefa re 500 mg. Zvinokurudzirwa kuti udye zvimwe zvekudya uye unwe girazi remvura yakazara kana uchidya sulfasalazine.
Chirwere cherheumatoid arthritis chinowanzotanga zvishoma nezvishoma. Kwevhiki yekutanga, varwere vanotora mapiritsi 1 kana maviri sulfasalazine zuva nezuva. Inogona kuwedzerwa kusvika pamapiritsi maviri kaviri pazuva. Iko inosvika mazamu matanhatu mapiritsi pazuva. Mahwendefa e-enteric-akabatanidzwa anowanikwa uye anogona kubatsira nemudumbu kushungurudzika.
Migumisiro Yechirwere Inowanzobatana Yakasangana neSulasalazine
Sulfasalazine inobatanidza nemamwe mashoma emagumisiro.
Zvikamu zvinowanzovhiringidza zvinokonzera kushushikana kana kushaya pamuviri. Zvinetso zvemuviri zvinoita sokuti zvinopedza nguva, kunyanya kana chirwere ichi chichipiwa pamwero wakaita pakutanga. Zvisingabatanidzi zvinosanganisa zvinogona kusanganisira kuputika kweganda, musoro wepamusoro, maronda emuromo, kutema, zvinetso nechiropa chinoshanda, uye zuva rekunzwa.
Zvinogona Kuitika Zvakanyanya Kuipa
Kukanganisa kwakaipisisa kunobatanidza ne sulfasalazine kunosanganisira anorexia, misoro yakakomba, yakakomba gastric dambudziko, kurutsa, uye pasi peperm count. Ihwo huwandu hwehutachiona hunogona kuchinjwa nekuregererwa kwechirwere. Izvi zvinoshungurudza zvinokanganisa nechetatu chevarwere vanobatwa ne sulfasalazine. Kukanganisa kwakashata kunobata vanopfuura vanopfuura 1 muvatatu vanotora sulfasalazine vanosanganisira kuora, mikoko, fever, Heinz body anemia, hemolytic anemia, uye cyanosis (bluish discoloration).
Kunyange zvazvo kupindira kwakakomba kwakanyanya kusingafungidziki kwakajairika, vanowanzowedzera apo chiitiko chezuva nezuva che sulfasalazine chakaenzana kana chinopfuura 4 gramu. Uyewo, pane zvimwe zvinopikisa zvinosangana ne sulfonamides (sulfa drugs) iyo inofanirwa kufungidzirwa inokwanisika ne sulfasalazine, kusanganisira kushaya ropa, kugadziriswa kwehutachiona, hutachiona hwehutano hwehutano, kushandiswa kwemhepo, uye urini uye kuputika kweganda.
Contraindications (Ndiani Asingafaniri Kutora Zvinodhaka)
Sulfasalazine haisi yakakodzera kurapwa kwoutano kune varwere vane mucheche kana mukuvhota, porphyria , kana kune varwere vane hypersensitivity vanozivikanwa sulfasalazine, sulfonamide, kana salicylates.
Manyevero uye Kuchengetedza
Kuita kuti kuderedzwa njodzi yemigumisiro kana kusangana kwakashata. iwe unofanirwa kunge uchiziva zvinotevera kunyeverwa nekuchengetedzwa paunenge uchishandisa sulfasalazine.
- Nguva dzose kuongororwa kweropa kunofanirwa kuitwa kuti kuongorore ropa, maitiro epfungwa, uye chiropa chinoshanda.
- Kana uri kuronga kuva nepamuviri, unokurudzirwa kukurukura kushandiswa kwe sulfasalazine nechiremba wako. Vakadzi vari kuyamwa havafaniri kutora sulfasalazine.
- Folic acid supplementation inogona kudikanwa kana iwe uri kurapwa ne sulfasalazine.
- Iva nehanya nekugona kushandiswa kwezvinodhaka ne sulfasalazine kana iwe uchitora Coumadin (warfarin), cyclosporine, kana digoxin. Iyo mishonga inogona kuwedzera njodzi yekukuvara kwechiropa kune varwere vanotora isoniazid nokuda kwehutachi. Sulfasalazine inogonawo kuwedzera njodzi yekushuga yepasi shoma pakati pevarwere vanotora mishonga yechirwere cheshuga.
Sources:
Sulfasalazine (Azulfidine). American College of Rheumatology. March 2015.
http://www.rheumatology.org/I-Am-A/Patient-Caregiver/Treatments/Sulfasalazine-Azulfidine
Rheumatoid Arthritis: Kuziva Kukura Kwekare uye Kuporesa. Kushi JJ MD, Weinblatt ME MD, Kavanaugh A MD Professional Communications, Inc. Chechitatu Gwaro. Copyright 2010.