Injectable biologic drug for rheumatoid arthritis
Adalimumab, inowanzozivikanwa seHumira, inodhaka yemishonga inoshandiswa nekuvhara puroteni inonzi TNF-alpha . Kazhinji, TNF-alpha inobatsira kurwisana nehutachiona, asi inowedzera yakawanda, inogona kukonzera kuputika kunorwadza uye kukuvadza kwakanyanyobatana (kureva zviratidzo zvakajairika zverheumatoid arthritis nemamwe maitiro ekuputika arthritis ). Zvinodhaka zvakadai saHumira zvakabatsira vakawanda varwere vemahapa ekurapa marwadzo nekudzivirira marwadzo, kuvandudza kubatana kwebasa, uye kuderedza kuwedzera kwezvirwere.
Overview
Humira munhu akazara humanized monoclonal antibody . Izvi zvinoreva kuti, kunyange zvazvo yakaitwa muhurongwa hwusati huri hwevanhu hwehupenyu hwehupenyu, chaiyo mapuroteni maitiro echirwere akafanana neaya evanhu vanorwisa zvirwere. Uye izvi zvakakurumbira Humira kubva pachigadziro cheMonoclonal antibody TNF icho chakabvumirwa zvisati zvaitika-mapuroteni ayo akagadzirwa muchikamu kubva kune asiri munhu (mouse) antibody.
Muna 2002, Humira yakatanga kugamuchirwa neU.S. Food and Drug Administration (FDA) senzira yekurapa rheumatoid arthritis. Icho chimwe chezvimwe zvinodhaka zvebiologic zvinodzivirira TNF-alpha, kusanganisira:
- Enbrel (Etanercept) : Mushonga wekutanga we-TNF wakagamuchirwa neDFA nokuda kwehutatoid arthritis uye zvimwe zvirwere zvinokonzera arthritis muna 1998.
- Remicade (Infliximab) : Yechipiri TNF inhibitor inogamuchirwa neCDA muna 1999.
- Simponi (Golimumab) : Yakagamuchirwa neDFA musi waApril 24, 2009.
- Cimzia (Certolizumab Pegol) : Yakagamuchirwa neDFA musi waMay 14, 2009.
Kusarudza
Humira inopiwa ne-subcutaneous (pasi peganda) kuzvirwisa kamwe kamwe kwevhiki mbiri. Varwere vangarayirwa nachiremba wavo kuti vauye muvhiki imwe neimwe kana mazuva gumi nemaviri asina kukwana.
Yaiva yekutanga inowanikwa mune imwe chete, sendira yakagara yazadzwa. Kushandiswa kumwe chete, iyo inoshandiswa kugadzirisa nzira yakagadzirwawo, inozivikanwa seHumira Pen.
Nhamba yakakurudzirwa, zvisinei, iine 40mg se-subcutaneous self-injection uchishandisa siringe yakagara yazadzwa kana Humira pen rimwe nerimwe vhiki. Methotrexate , dzimwe DMARD dzisina-biologic, glucocorticoids , nonsteroidal anti-inflammatory drugs (NSAIDs) , kana analgesics (mishonga yemarwadzo) inogona kupfuurirwa apo inorapwa neHumira. Zvisinei, mamwe maDMARD e biologic haafaniri kushandiswa.
Zviratidzo
Zvimwe zviratidzo zvakawedzerwa neHuma kubva pakutanga zvakagamuchirwa neDFA. Inogona kurairwa kuti iite zvakare:
- Rheumatoid Arthritis
- Ankylosing Spondylitis
- Psoriatic Arthritis
- Juvenile Idiopathic Arthritis
- Plaque Psoriasis
- Ulcerative Colitis
- Chirwere chevanhu vakuru uye chirwere cheCrohn
- Hidradenitis Suppurativa
Migumisiro Yechiri
Matambudziko anowanzoenderana neHumira anosanganisira:
- Mwoyo jekisi site site reaction
- Mapundu
- Headache
- Dumbu rinoshungurudza kana kusuruvara
- Pneumonia
Zvakaipa Kuchinja
Nemhaka yokuti inoderedza zvirwere zvekuzvidzivirira mumuviri mumuviri unowanzopikisa hutachiona, Humira yave ichibatanidzwa nehutachiona hwehutachiona, hwakadai sechirwere chetachiona, sepsis, uye utachiona hwehutachiona. Zvinogonawo kuwedzera zviratidzo zvezvirwere zvehutachiona hwehutano (semuenzaniso, kuora mwoyo kunoderedza). Mumakiriniki ekuedzwa, vamwe varwere vaiva nezvikwereti zvakakwirira zvekenza uye lymphoma kwemwedzi 24.
Ndiani Asingafaniri Kutora Humira
Humira haafaniri kushandiswa nevarwere vane inozivikanwa kuti vashandise mishonga kana zvikamu zvayo. Icho hachisiwo kushandiswa nevarwere vane pamuviri kana mukoti.
Mushonga wacho haufaniri kutarisirwa kumurwere ane chirwere chakakomba kana varwere vanochengeterwa utachiona, kusanganisira varwere vane chirwere cheshuga chisina kudzora kana varwere vane nhoroondo yezvirwere zvinowanzoitika.
Taurira Chiremba Wako
- Kana iwe uine utachiona hunoshanda
- Kana iwe uine hutachiwana neHepatitis B kana uri mutakuri (Humira yave ichibatanidzwa nekugadzirisa kweHepatitis B)
- Kana iwe uine kupera, kutling, kana multiple sclerosis kana kuti inonzi central nervous system disorder
- Kana iwe wakarapwa nokuda kwekukundikana kwemoyo
- Usati wagamuchira chero zvirwere kana chirwere
Kuti uone kushushikana kwakaipisisa kusakanganiswa, unogona kutaura naAbbVie Inc.at 1-800-633-9110 kana FDA pa 1-800-FDA-1088 kana www.fda.gov/medwatch.
Sources:
Zashin, MD, Scott J .. Arthritis Pasina Uturu. Sarah Allison Publishing Company.
Humira . Abbott laboratories. Kunyora Mashoko. 2016.