Mishonga inopedza COX inogona kunge isina chinhu chakanaka
Kuchema uye kuputika, kunyunyuta kwekutanga kwevanhu vakawanda pane imwe nguva muupenyu hwavo uye kuitika kwemazuva ose kune vanhu vazhinji vane arthritis, ndiko kunokonzerwa ne cyclooxygenase, kana COX, kwenguva pfupi.
COX inyanzvi inoumba prostanoidhi- prostaglandin , prostacyclins, uye thromboxanes-iyo yose inokonzerwa nemhinduro yekuvhiringidza.
Icho chinoitika kuti COX haisi yose yakaipa, iyo inotodiwawo kune dzimwe nguva maitiro emagetsi.
Zvinodhaka zvinoshandiswa pakudzivisa COX pakusunungura kuvhuvhuta, zvinoita sepfungwa yakanaka, asi nekudzivisa COX, kune dambudziko.
COX-1 pamwe ne COX-2
Mumakore ekuma1990, zvakaonekwa kuti paiva nemhando mbiri dze enzyme COX-1 uye COX-2. Izvozvo ndezvezvinodiwa zvishoma zvezviviri. COX-1 inozivikanwa kuvapo mumatumbu akawanda. Muchikamu chepamuviri, COX-1 inochengetedza chidimbu chepachizvaro chemuviri uye inodzivirira mudumbu kubva kumakisi ekudya. Iyo enzyme inobatanidzwawo muinso neplatelet basa. COX-2 inonyanya kuwanikwa panzvimbo dzekuvhiringidza.
Zvose COX-1 ne COX-2 zvinogona kukonzera marwadzo nekuputika, asi sezvo COX-1 iyo inyanzvi inobatsira, kushandisa madhiragi kuvhara kungasave iyo pfungwa yakanaka.
NSAID Inhibit COX
Nonsteroidal anti-inflammatory drugs (NSAIDs), inowanzogadzirirwa kurapa arthritis, inoshanda nekudzivisa prostaglandin. NSAID dzeMutambo, kufanana ne ibuprofen uye naproxen, dzinogona kukonzera zvinetso zvemagumisi kusanganisira zilonda .
Iyi NSAIDs is nlelective, zvinoreva kuti inhibit both COX-1 ne COX-2. Kuvhiringidzika kwe COX-2 nemasikirwo emadzinza eNSAID kunobatsira kuti zvirwere zvinopesana nezvirwere, asi kukanganiswa ndiko kuvharwa kwe COX-1 kunogona kutungamirira kumigumisiro yakadai sevonda, nguva yeropa rinopera uye zvinetso zvepvo.
COX-2 Sarudzo NSAIDs
Mukupera kwema1990, makambani emishonga akashandisa mishonga yakawanda yakakonzera COX-2 chete, idzi NSAID dzaiva Celebrex, Vioxx, uye Bextra.
Pakati peizvi, Celebrex ndiyo chete mishonga inoramba iri pamusika muUnited States uye ine bhokisi rakasvibiswa kuti rinotakura dambudziko rekurwadziwa kwepfungwa uye kurohwa.
Sezvo kubviswa kweVixx muna 2004, US Food and Drug Administration yakatsvaga kirasi yose yezvinodhaka, kusanganisira zvose NSAIDs uye COX-2 inhibitors zvakatengeswa pamusoro pe-counter kana kuti nemishonga, uye yakawedzera nyema mabhenekeri kune zvakaraira mirairo .
Zvimwe zviviri COX-2 inhibitors, Arcoxia uye Prexige, izvo zviri kushandiswa kune dzimwe nyika, zvakarambwa neDFA. Prexige yakabviswa pamusika muAustralia neCanada nekuda kwekukanganiswa kweropa.
Vamwe vatsvakurudzi vanotenda, mushure mekunge vawana zvikamu zvakaderera zve COX-2 mune zvimwe zvisizvo zvisingaiti, kuti COX-2 inogonawo kuita basa mune zvimwe zviito zvemuviri kunze kwekuputika. Vatsvakurudzi vomuUk vakawana kuti COX-2 inogona kudzivirira kurwisa atherosclerosis, izwi rezvokurapa nokuda kwekuoma kwe arteri, kuderedza nekuvhara.
Nepo NSAIDs uye COX-2 inhibitor inofungidzirwa sarudzo dzinokosha dzevarwere varwere , mararamiro uye njodzi dzinofanira kufungwa kune mumwe murwere mumwe nomumwe. Kungozi yemwoyo uye iyo yakanakisisa yeNSAID yekushandisa inofanira kuongororwa.
> Sources
> Arthritis Foundation. NSAIDs.
> Bathon, Joan M. Kukurukurirana kweZvamwe COX-2 Inhibitors. Johns Hopkins Arthritis Center.
> Kirkby N, Lundberg M, Wright W, Warner T, Paul-Clark M, Mitchell, J. COX-2 Inodzivirira Kurwisa Atherosclerosis Kuzvimiririra kweVascular Prostacyclin: Kuzivikanwa kwe COX-2 Associated Pathways Implicate Rgl1 uye Lymphocyte Networks. PLOS Rimwe. June 2, 2014.