Cimzia isimbi yeTNF inoshandiswa mukuputika arthritis
Cimzia (certolizumab pegol) inonzi TNF (tumor necrosis factor) blocker -chirwere chechirwere chakafanana seEbrel (etanercept) , Remicade (infliximab) , Humira (adalimumab) , uye Simponi (golimumab). Cimzia ndiye mishonga chete mukirasi yeTNF inobata kusava neuturu kumasero nekuda kwemakemikari ayo (semuenzaniso, PEGylated, Fc munharaunda yakasununguka). Mukuwedzera, achifananidzwa kune dzimwe TNF blockers, Cimzia inonzi iine ukama hwepamusoro hwe TNF yevanhu.
Chii chinonzi TNF?
Inobatsira kuziva kuti TNF ndeyekuti iwe unogona kunzwisisa zviri nani nei Cimzia inoshanda kuchidzivisa. TNF inonzi cytokine , inosanganisira mutemo wenhemiyumu pakati pemasero, iyo inobata basa mukuvhiringidza . Zvakawandisa TNF-alpha kubudiswa nemuviri zvakabatanidzwa nezvirwere zvakasiyana siyana uye zvinetso, kusanganisira rheumatoid arthritis .
Cimzia Inopiwa Sei?
Cimzia inorohwa pasi peganda. Iyo inopiwa semupfu unofanirwa kuyananiswa zvakare mukugadzirwa kwemvura kuitira kuti inogona kupiwa sechikamu chemukati.
Muiti waro, UCB, Inc., akataura kuti iyo yakasiyana-siyana yemakemikari yeCimzia inogona kuita kuti ive sarudzo iri nani kupfuura iyo iripo TNF blockers ye rheumatoid arthritis patients. Zvigadzirwa zvayo zvinogona kuderedza kusagadzikana kwakasangana nejojo uye kushandiswa kwezvinodhaka kunzvimbo dzekuputira kunogona kuvandudzwa, kunoda kudarika kudarika nguva yakawanda kupfuura dzimwe injectables.
Mushure mekutanga kwechirwere, pane chirongwa chepamusoro chekuita maitiro.
Cimzia inogona kupiwa panguva dzemavhiki maviri kana mana-iri yoga kana ine methotrexate.
Cimzia Performance in Clinical Trials
Chirwere chechipatara chemuedzo chakakonzerwa neCimzia. Zvidzidzo zviviri zvechikamu chechitatu zvakaratidza kubatsirwa kukuru apo Cimzia yakashandiswa ari yoga kana pamwe chete ne methotrexate kuvanhu vakuru vane rheumatoid arthritis (kureva, inoshanda synovitis ).
Kunyanya, mavhiki 24 eFAST4WARD yakaratidza kuti 400 mg yeCimzia, yakapiwa masvondo mana mashoma pasi, zvakanyanya kuderedza marwadzo uye zviratidzo uye zviratidzo zve rhumumidhi arthritis nekuvandudzwa kwemuviri wekuenzanisa neavo vari panzvimbobo.
Zvidzidzo zveRAPID zvakaratidza kubatsirwa kwekushandisa Cimzia pamwe ne methotrexate. RAPID1 yakaratidza nguva yakareba kubatsirwa pakushandisa Cimzia maererano nekununurwa kwechiratidzo, kuvandudza kubudirira uye hupenyu hwehupenyu, uye kuderedza kuneta. Chechipiri RAPID yekudzidza, inozivikanwa seRAPID2, yakaratidza kuti Cimzia pamwe ne methotrexate yakavandudza zviratidzo uye zviratidzo zve rheumatoid arthritis, kuvharidzira kufambira mberi kwechirwere ichi, nekuvandudzwa kwechiito chemuviri kune varwere vane hutachiona hwehutano hutachiona.
Cimzia Side Effects
Matambudziko makuru akakurira mune vamwe vanhu vanotora Cimzia. Iyo inorondedzera ruzivo runowanika kuCimzia inonyevera nezve:
- Zvirwere zvakakomba, kusanganisira tuberculosis
- Kanzira, kusanganisira lymphoma
- Nervous system zvinetso, kusanganisira multiple sclerosis
- Allergic reactions
- Dambudziko reRopa
- Itsva kana kuti yakaipa mwoyo kusakundikana
- Maitiro ekudzivirira muviri, kusanganisira lupus-like syndrome
Zvipembenene zvakanyanya zvinowanzobatanidzwa neCimzia zviripamusoro zvekufema zvirwere, zvirwere zvekuvhenekera, urwere pamwe chete, uye injection site reactions.
Is Cimzia FDA-Approved?
Musi waApril 22, 2008, Cimzia aiva FDA-yakagamuchirwa kubata chirwere cheCrohn chakanga chisinganzwisisiki kune vanhu vakuru vasina kubatsirwa nemaitiro ekurapa. Musi waMay 14, 2009, Cimzia yakagamuchirwa neRDA kurapa varwere vakura vanove nemwero kuti vaite zvakanyanya rheumatoid arthritis. Zviratidzo zvakare zvakawedzerwa zve psoriatic arthritis uye ankylosing spondylitis .
Cimzia inowanikwa mune siringi inotanga kuzadza iyo inotakura Arthritis Foundation's Ease-of-Use Commendation. Izvo zvakagadziriswa nesirinho ndeyekugadzirisa kwehukama pakati peUCB neOXO (inonyatsozivikanwa nemutsara wavo we ergonomic midziyo yekubika nemimwe midziyo inoshandiswa nevashandi).
Sources:
Cimzia. Kunyatsorondedzera Mashoko. UCB. Yakarongwa muna April 2016.
http://www.cimzia.com/assets/pdf/Prescribing_Information.pdf
Cimzia. Mishonga Gwaro. UCB, Inc. Revised April 2016.
http://www.cimzia.com/assets/pdf/MedicationGuide.pdf