Uloric (febuxostat) yakagamuchirwa neU.S. FDA musi waFebruary 13, 2009. Uloric ndiyo yakatanga kusarudzwa mushonga mumakore makumi mana kuvarwere vane hyperuricemia uye gout, maererano naTaceda Pharmaceuticals North America, Inc.
Uloric imishonga inoshandiswa kwehupenyu husingaperi hwehuwandu hwehutachiona mune gout. Uloric inoderedza serum uric acid mazinga nekuvhara xanthine oxidase-iyo enyzme inokonzera uric acid inogadzirwa.
Xanthine oxidase inoputsa hypoxanthine (yepanyama-inoitika purine inogadzirwa) ku xanthine, uyezve kuUric acid.
Ko Uloric Inotungamirirwa Sei?
Maitiro anodiwa eUloric ndiwo 40 mg uye 80 mg anopiwa kamwe chete zuva nezuva. Uloric inorapwa mishonga (inotorwa nemuromo). Iyo inotenderwa kutanga chirwere cheUloric is 40 mg kamwe zuva nezuva. Kuwedzera kusvika ku 80 mg kunorumbidzwa kune varwere vasingakwanisi kuwana serum uric acid inopfuura 6 mg / dL mushure mevhiki mbiri pa 40 mg dose. Uloric inogona kutorwa pamwe kana kuti isina kudya uye hapana mazano anokudzivirira kushandiswa kwevarimidhi. Hapana kuchinjwa kwechirwere kunodiwa kuvarwere vane runyoro kusvika kuenzanisire kana kuti kushaya hupenzi.
Kuita muMitambo Yezvipatara
Mumakiriniki ekuedzwa, hutachire hweUloric hwakawanikwa hunobudirira kupfuura placebo kana kuti muzinga weallopurinol - imwe mishonga inoshandiswa kurapa hyperuricemia. Uyewo, mumwedzi wemwedzi mitatu-kutongwa-chiyero chevarwere vegout, avo vakaderedza uric acid mazinga aidiwa pasi pe6, zvakanyanya zvakanyanya kune avo vanotora 80 mg kune avo vanotora 40 mg yeUloric.
Migumisiro Yechipfuva uye Manyevero
Uloric haina kukurudzirwa kuvanhu vane zvirwere zvekushaya ropa. Uloric haifaniri kushandiswa nevanhu vanenge vatotapwa ne azathioprin (Imuran), mercaptopurine, uye theophylline.
Kubva pamatatu emakiriniki, akachengetedzwa kwechiremba, chiropa chebasa chisina kuitika, chirwere chinopisa, arthralgia, uye kuputika ndiwo maitiro anowanzovhiringidza anowanzoitika munharaunda inenge 1% yevarwere vanobatwa neUloric uye zvinenge 0.5% kupfuura nzvimbobo.
Uyewo, zvichienzaniswa neallopurinol, Uloric yaibatanidza nepamusoro yepamusoro yezviitiko zvepfungwa zvepromboembolic, asi hapana hukama hwakananga hunoonekwa. Chiropa basa risingakanganisi ndiyo yaive yakaipisisa yakaipisisa yakaita kuti kuregererwa kweUloric.
Pakave nemishumo yekugadzirisa hutachiona hwekukundikana kwehepatic, inouraya uye isina kuuraya, kune varwere vanobatwa neUloric. Iyo mitsara yakanga isina dhaibha yakakwana yekusimbisa chikonzero chinokanganisa asi.
Kuwedzera kwe gout flares kunowanzowanikwa apo vanorwara-hyperuricemic agents vanotanga. Icho chinosanganisira Uloric. Kana gout flare iyo inobatanidzwa nekutanga kweUloricrapi inowanikwa, mishonga haifaniri kurega. Kuti udzivise gout flares inobatanidzwa nekutanga kweUloricrapi, NSAID kana colchicine inogona kutorwa panguva imwe chete. Kuwedzera kwe gout flares kwave kunonzi kunoderedzwa kwema serum uric acid iyo iyo, iyo inokonzera kufamba kwehuate kubva kune zvigunwe.
Pakanga pasina kuongororwa zvakanaka kweUloric muvakadzi vane pamuviri. Mune pamuviri, Uloric inofanira kushandiswa chete kana inotarisirwa kubatsira inowedzera mungozi yemucheche. Uyewo, hazvizivikanwe kana Uloric yakanyanyiswa mumukaka wemunhu.
Vakadzi vanoyamwisa vanofanira kunge vakangwarira.
Kuchengetedzwa uye kubudirira kweUloric muvana vasati vava nemakore gumi nemasere hazvizivikanwi.
Sources:
Uloric Kunyora Mashoko. Uloric.com. Takeda Pharmaceuticals Inc. Revised March 2013.
FDA Inobvumira ULORIC® (febuxostat) yeHIV Management of Hyperuricemia muVavana neGout. Takeda Pharmaceuticals. February 13, 2009.