Kushandiswa kwakachengeteka kwechirchicine kunoderedza zvisingadiwi zvikamu
Colchicine ndiyo inofanirwa kurapa gouty arthritis. Kunyange zvazvo chirwere ichi chiri chinhu chakakosha chokurapa gout , pane zvakawanda izvo zvisingazivikanwi nezve colchicine. Semuenzaniso, kuti colchicine inoshanda sei, kubva kwainobva, inotora nguva yakareba sei mushonga wemishonga, uye inonyanya kukosha, zvaunoda kuziva kushandisa mushonga zvakanaka.
Chokwadi Chinokosha Pamusoro peColchicine yeGout
1.
Colchicine inonzi alkaloid inobva pamichero yakaomeswa yeColchicum autumnale, inozivikanwawo sevotori crocus kana meadow safoni.
Kushandiswa kweColchicum alkaloid pakurapa gout yakaoma kwakadzoka kare muna 1810. Kurapa kwechirwere chechichichi kwakadzokidzwa zvakare muzana ramakore rokutanga AD ADCchicine yakashandiswa kugadzirisa mamiriro asiri kune gout, kusanganisira:
- Amyloidosis
- Chirwere cheBehcet
- Dermatitis herpetiformis
- Familial Mediterranean fever
- Paget's disease
- Pericarditis
- Pseudogout
- Biliary uye hepatic cirrhosis
2. Colchicine inowanika mumuromo kana mukati maitiro.
Colchicine inowanikwa mumasimba maviri emuromo - 0.5 mg uye mapiritsi 0,6 mg. Chirwere ichi chinowanikwawo mukati megungwa, asi pane inogona kuisa tsvina yakawanda uchishandisa parenteral nzira (kureva, inopera kana injection, imwe nzira kunze kwegadziriro yekudya).
3. Colchicine ine-anti-inflammatory properties, asi kushandiswa kwayo kwemarudzi ehutano kunze kwekuti gout ishoma.
Kunyange zvazvo colchicine inonzi inobatsira zvikuru pakurapa gouty acute arthritis, haisi inoshanda kune marudzi ose emarwadzo. Colchicine haifaniri kuonekwa sean analgesic drug (kureva, painkiller). Izvo hazviiti kuti uric acid isagadziriswe.
4. Colchicine inoshanda zvakasiyana nedzimwe marwadzo anoremekedza kana anti-inflammatory drugs.
Colchicine inosunga kune mapuroteni mu microtubules ye neutrophils. Neutrophils inoratidziro yeropa rega rega . Nokusunga neutrophils, masero haagoni kuenda kune imwe nzvimbo yekuvhiringidza kupikisa uric acid crystal inogadzirisa. Colchicine ine simba rinoparadza rinobatsira kuderedza kuputika kwakanyanya kwegout , nokudaro kubvisa marwadzo uye kusagadzikana kunosangana ne gout.
5. Colchicine inokurudzirwa kuti ishandiswe nguva dzose pakati pekurwiswa sechirevo cheprophylactic uye inogona kuva yakagadzirisa pakurwisa kurwiswa kana yakatorwa pachiratidzo chokutanga chekusagadzikana.
Chirwere chinowanzogadziriswa kuti usununguke gout kurwisa 1 kusvika ku 1.2 mg (maviri 0.5 mg kana maviri mapiritsi 0,6 mg). Iyi nhamba inogona kuteverwa neyuniti imwechete yehwendefa rega simba rimwe nguva, kana mairi maviri maawa maviri kusvikira hurwadzi hukasunungurwa. Mushure mokutanga mazai, dzimwe nguva zvakakwana kutora 0.5 kana 0.6 mg maawa maviri kana matatu maawa. Mushonga unofanirwa kumira kana kune hutachiva husina kunaka kana chirwere.
6. Colchicine inogona kuendeswa mberi nekuchengetedzwa.
Mune varwere vane chirwere chisingapfuuri gout kushanda pagore, chiitiko chinowanzoitwa 0.5 kana 0.6 mg pazuva, mazuva matatu kana mana pavhiki. Kune avo vane huwandu hunopfuura kamwechete pagore, chirwere chinowanzoitwa 0.5 kana 0.6 mg zuva rega rega.
Matambudziko akakura angada maviri kana matatu matatu mg kana mapiritsi 0,6 mg zuva nezuva.
7. Kuchinja kwakashata kunogona kuitika nekushandiswa kwecolchicine uye zvakakosha kuti iwe uzive izvo zvinogona.
Bhata marrow depression, neaplastic anemia, neagranulocytosis, kana ne thrombocytopenia inogona kuitika kune varwere vanowana kurapwa kwenguva refu.
Zvimwe zvinogona kuitika zvakashata zvinosanganisira:
- Peripheral neuritis
- Purpura
- Myopathy
- Kuora bvudzi
- Reversible azoospermia (kusakwana kwese kwemuviri)
Kusvetwa, kurarisa, uye kushungurudza kunokonzerwa nemigumisiro inogona kuitika ne colchicine therapy, kunyanya apo inodhura madhesi inorayirwa.
8. Vakadzi vane pamuviri vanofanira kuyera njodzi uye kubatsira kwecolchicine.
Colchicine inofanira kushandiswa panguva yekudzivirira chete kana zvingave zvichibatsire zvinopa chikonzero chinogona kuisa njodzi kumucheche. Colchicine inogona kusunga cell division, saka inogona kunge iri ngozi yakawanda yekutora chirwere ichi paine pamuviri. Kuchenjerera kunofanirawo kushandiswa apo colchicine inotarisirwa kune mukadzi anoyera.
9. Colchicine haifaniri kushandiswa nevamwe varwere.
Colchicine haifaniri kushandiswa nemunhu anozivikanwa hypersensitivity kune mishonga, kana nemurwere ane chirwere chakakomba chepachiviri, chekudzivirira, chinoputika, kana chirwere chemoyo. Uyezve, varwere vane dambudziko reropa havafaniri kushandisa colchicine.
10. Colchicine inoda chiremba chakanyorwa nachiremba wako.
Colchicine ndiyo mishonga yemishonga inowanikwa mune maitiro evanhu uye sezita rechiratidzo chemishonga, Colcrys (0,6 mg tablet). Kuti kuderedzwa migumisiro, colchicine inogona kutorwa nechingwa.
Sources:
Colchicine. RxList. IInternet Drug Index. Yakadzokororwa 10/04/2010.
http://www.rxlist.com/colchicine-drug.htm
Colchicine. MedlinePlus. 02/01/2010.
https://www.nlm.nih.gov/medlineplus/druginfo/meds/a682711.html
Colcrys. Update 12/2015.
https://www.colcrys.com/
Kelley's Textbook yeRheumatology. Elsevier. Ninth edition. Chitsauko 95: Zvinyorwa zveKliniki uye Kurapwa kweGout - Colchicine.