Yokutanga TNF Blocker Yakagamuchirwa neRheumatoid Arthritis muna 1998
Enbrel (etanercept) inonzi biologic response modifier (a recombinant human soluble tumor necrosis factor receptor fusion protein). Enbrel inogadziriswa kuti iite seyakagamuchira mumuviri unosunga kumarara necrosis factor (TNF-alpha). Enbrel inoshanda kuburikidza nekuchera zvakanyanya TNF isati yasvika kune zvinyorwa zvepanyama.
TNF-alpha inonzi cytokine inobatanidzwa mukuvhiringidza.
Kunyanya TNF-alpha yakabatanidzwa ne rheumatoid arthritis uye mamwe maitiro ekuputika arthritis .
Zvimwe zvinodhaka
Enbrel yaiva yekutanga-anti-TNF mishonga uye yakagamuchirwa muna 1998 nokuda kwerheumatoid arthritis nezvimwe zvinokonzera kurwisa kweArthritis. Remicade (infliximab) yaiva yechipiri TNF inhibitor inobvumidzwa neU.S. Food and Drug Administration muna 1999. Humira (adalimumab) yakagamuchirwa muna 2002. Simponi (golimumab) yakagamuchirwa neDFA musi waApril 24, 2009. Cimzia (certolizumab pegol ) yaiva FDA-yakagamuchirwa musi waMay 14, 2009.
Enbrel yakagadzirwa nokuisa DNA yevanhu muChinese hamster ovary cells uye kugadzira mapuroteni anogadzirwa nemajini. Remicade inoshandisa vanhu uye mapuroteni emapurogiramu ekuumba chimeric monoclonal antibody . Humira anoshandisa zvakakwana mapuroteni evanhu uye phage kuratidza teknolojia kuti ibudise monoclonal antibodies.
Administration
Enbrel inoshandiswa sechikamu chemukati kamwe kana kaviri vhiki (mazuva matatu kana mana oga).
Nhamba yakatarwa inotarisirwa nemamiriro ekurapa. Enbrel inofanira kunyorerwa nachiremba wako uye inoda inshuwarisi isati yatumirwa. Enbrel inogona kushandiswa mukubatana ne methotrexate kune varwere vasingateereri methotrexate chete.
Prescription
Enbrel yakagamuchirwa kuti iite zvishoma nezvishoma kune yakaoma rheumatoid arthritis, inononoka kusvika kune yakanyanya mwana wechirwere rheumatoid arthritis , psoriatic arthritis , ankylosing spondylitis , chronic modate to severe plaque psoriasis.
Yakarongwa Dosage
Kuvanhu vakuru vane rheumatoid arthritis, psoriatic arthritis, uye ankylosing spondylitis, chirwere chinowanzoitwa Enbrel chinokwana 50 mg pavhiki rinochengetwa senzira inogadziriswa shandisa s 50 mg / mill kushandiswa kamwe chete. Pane mamiriyoni 25 mg eEbrel anowanikwawo.
Muyero weEbrel wakagadzirirwa vana vechirwere rheumatoid arthritis unobva paukuru hwemwana. Kamwe kamwe-sabata dosing sarudzo inowanikwa yevana inorema 138 lbs kana kupfuura. Pamusoro pe psoriasis , chirwere chinowanzoitwa 50 mg kaviri pavhiki kwemwedzi mitatu, chakadzika kamwe kamwe kwevhiki.
Kunyanya Kunetseka
Enbrel haina kukurudzirwa kuvakadzi vane pamuviri kana kuti vakwegura. Varwere vane zvirwere zvakakomba havafaniri kutarisirwa neEbrel. Vanhu vanoita zvirwere kana vane vane chirwere cheshuga chisina kudzora havafaniri kushandisa Enbrel. Varwere vane mamwe mamiriro ehutano hwemagetsi vanofanirawo kudzivisa Enbrel.
Nharaunda Dzakabatana
Matambudziko anowanzobatanidzwa neEbrel anosanganisira:
- injection site reactions
- kuputika kwezvirwere, kusanganisira sinus zvirwere
- headaches
- chizoro
- dzihwa
- huro hutsamwa
Kuchinja Kwakaipisisa Kwakaipa
Enbrel inogona kuwedzera njodzi yehutachiona hwakakomba. Muvanhu vanobatwa neEbrel, pane zvakaitika kune multiple multiple sclerosis , myelitis (kuvhuvhuta kwemutsara), optic neuritis (kuvhiringidza kweptic nerve), uye pancytopenia (nhamba shoma dzemasero matsvuku, masero machena, maplatelet).
Kuchengetedza
Enbrel inofanira kuchengetwa pakushambidzwa kwe 36 kusvika ku 46 degrees Fahrenheit. Zvisinei, Enbrel inogona kuchengetwa mukati mekupisa kwemazuva kwemazuva gumi nemaviri. Enbrel haifaniri kuchengetwa mufiriji.
Maererano ne-enbrel.com, kana uchifamba kwemaawa mashomanana, unofanira kuvhara Enbrel muuputi woupfu uye uiise mumhepo inotonhorera yakazara nechando. Wedzera thermometer kune inotonhora uye uone iyo nguva maawa mashomanana. Iwe unogona kuwana mahwendefa ekufambisa kwepachena uye ice pack yeEnbrel nokudana Enbrel Support pa 1-888-4ENBREL. Kana uchifamba nemhepo, chengetera newayendaneti nekuda kwezvavanoda.
Sources:
Arthritis Pasina Utano, Scott J. Zashin, MD, Yakabudiswa naSarah Allison Publishing Company.
Enbrel - The Pill Book, 10th Edition
Mishonga Gwaro. Enbrel.com. Revised 11/2013. http://pi.amgen.com/united_states/enbrel/derm/enbrel_mg.pdf
Kunyora Mashoko. Enbrel.com. Revised 03/2015. http://pi.amgen.com/united_states/enbrel/derm/enbrel_pi.pdf