Mukupera kwema1991, chiremba chekutanga che biologic chakaenda pamusika kurapa rheumatoid arthritis . Enbrel (etanercept) yakatanga, asi haina kutora kwenguva yakareba kuti mamwe madhiragi biologic apiwe uye atengeswe.
Maererano neUpToDate (inodavirwa nemagetsi inoshandiswa nevarapi vakawanda nevarwere vachitsvaga zvakadzama uye zvakanyatsotsanangurwa nezvehutano).
"Biologic response modifiers, iyo inozivikanwawo sebiologics, inoshandiswa kudzivirira kana kuderedza kusuruvara kunokanganisa majoini. Biologics inotora mamolekemu pamasero ezvirwere zvemuviri, masangano, uye zvigadzirwa zvakavanzwa musangano, izvo zvose zvinogona kukonzera kuvhuvhuta nekubatana pamwe chete. Kune mhando dzakawanda dzebiologics, imwe neimwe inotarisa imwe rudzi rwemalekoro inobatanidzwa mune izvi (tumor necrosis factor, interleukin-1, uye masero emaserolekisi paT uye B lymphocytes). "
Biologic Zvinodhaka Nezvinangwa Zvadzo
- Enbrel (etanercept), Remicade (infliximab), Humira (adalimumab), Simponi (golimumab), uye Cimzia (certolizumab pegol) zvinodhaka zvinokonzera tumor necrosis factor (TNF). Izvo zvinowanzozonzi TNF blockers uye, kazhinji, imwe yeTN blockers ndiyo yekutanga biologic drug yakaedzwa.
- Kineret (anakinra) inhibits interleukin-1. Iyo inowanzoonekwa sechinhu chisingaitiki biologic kupfuura TNF blockers uye isingawanzogadziriswa.
- Orencia (abatacept) inoparadza kushandiswa kwemasero eT. Kazhinji, Orencia yakachengetwa kune varwere vane mwero wakanyanya kuoma rheumatoid arthritis avo vasingakwanisi kutarisira chirwere chavo ne methotrexate uye blocker yeTNF.
- Rituxan (rituximab) inoderedza masero B. Zvakare, ichi chinodhaka chinowanzochengeterwa varwere vane chigumisiro chisingagutsikane ne methotrexate uye blocker yeTFF.
- Actemra (tocilizumab) inoshanda nekudzivisa interleukin-6 receptor, nekudzivirira interleukin-6.
Ndivanaani Vanofanirwa Kubatwa Nezvisikwa ZvechiGiriki?
Varwere vakave nemhinduro isina kugutsikana kuna DMARD (chirwere-modifying antirheumatic drugs), kana iri voga kana pamwe chete nemamwe mishonga yeArthritis, kazhinji inowanikwa zvakanaka kune biologics. Kuenzaniswa neDMARD, biologics inoshanda zvakakurumidza. Iwe unofanirwa kuziva kana iwe uri kupindura mukati memavhiki mashoma ekutanga biologic drug.
Ndivanaani Vasingafaniri Kubatwa Nezvisikwa ZvechiGiriki?
Zvinosuruvarisa, kune varwere vasiri ivo vakakodzera kurapwa nemishonga ye biologic. Kune dzimwe mamiriro ezvinhu apo njodzi dzingangodaro dzinopfuura zvakakosha zvekurapa nemishonga inonzi biologic.
Semuenzaniso, varwere vane nhoroondo yekare ye multiple sclerosis kana lymphoma vangave vasina kunaka. Varwere vane zviratidzo zvinokonzera kupesana mwoyo kusakundikana havakwanisiwo. Zvakanyanyawo kuipa kushandisa biologic zvinodhaka apo murwere ane nhoroondo yezvirwere zvakakomba kana zvekare.
Ndeipi yeBioologics Unofanira Kuishandisa?
Chiremba wako achakubatsira iwe kusarudza zvakanakisisa biologic kwauri. Mari inowanzofungidzirwa. Iwe uye chiremba wako unofanira kusarudza kana utano hwako hwehutano huchavhara mishonga yaunosarudza-kana kuti mari yako yapi-ye-muhomwe ichave iri.
Iva nechokwadi kuti iwe unogona kutenga.
Chimwe chikonzero chakanaka. Mishonga inoshandiswa sei? Iwe unofanirwa kuenda kuhofisi yechiremba kuti uwane mushonga here kana zvingave zviri nani kwauri kuti usarudze imwe yemishonga inonzi biologic iyo inotarisirwa seyo self-injection? Kakawanda sei mushonga unobatwa-kamwe kamwe pavhiki, kaviri pavhiki, vhiki mbiri, kana mwedzi? Chii chaunofarira?
Uyezve, zvakakosha here kuti iwe usarudze mishonga ine ruzivo rwakanaka, mune mamwe mazwi, mumwe wevakuru, panzvimbo pekupedzisira, biologics? Izvi zvose zvinhu zvokufunga nezvazvo nokuti kana ukasarudza zvinokufananidza iwe zvakanakisisa, iwe ucharamba uchienderana nemishonga yako.
Kunobva:
Maini RN uye Venables PJW. "Ruzivo rwevarwere: Rheumatoid arthritis treatment" UpToDate.