Chirwere cheArabiotic Chichibudirira KuRhumatoid Arthritis?
Nhoroondo yekutsvaga Chikonzero neChirwere
Nechirwere chisingazivikanwi chemazana anopfuura zana eArthritis , kurapwa uye kubata nemarwadzo anorwadza kwava chinhu chikuru chekutarisira varwere uye vanachiremba. Mumakore ekuma1930, chikonzero chebhakitiriya cherheumatoid arthritis chakaongororwa, asi tsvakurudzo yakagara kwenguva pfupi kunze kwematambudziko akasiyana-siyana echirwere chinotapukira kana septic arthritis .
Muna 1939, mutungamiri chaiwo wekutanga pamusoro pechikonzero chinotapukira cherheumatoid arthritis yakamuka apo mycoplasma, aypical viral-like bhakitiriya, yakange yakasarudzwa kubva kune yakawanda uye mavara evanhu vane rheumatic varwere. Vatsvakurudzi vakanga vatove vakaratidza kuti mycoplasmas inokonzera arthritis mumakonzo, makonzo, huku, mbudzi, uye mhou. Vakanga vawana mycoplasmas mumaturakiti e genitourinary evanhuwo, kunyanya vakadzi.
Muna 1949 paInternational Congress paRheumatic Diseases ukama hunobvira pakati peecoplasmas uye zvirwere zvekubatana zvakataurwa. Mushure mekutora imwe yenyika yekutanga yeNational Institutes of Health (NIH) tsvakurudzo dzekutsvakurudza muna 1950, Thomas McPherson Brown, MD uye avo vaishanda navo pakutsvakurudza kweArthritis unit vakataura gore rakatevera kuti chirwere cherumatoid mechanism chaive chechirwere chekudzivirira kweAntigen and antibody ( ne mycoplasma sezvinofungidzirwa kuti antigen) panzvimbo yehutachiona hunotapukira uye hunopfurikidza.
Muna 1955, chikwata chekutsvakurudza chakashuma kuti mycoplasmas, kusiyana nemabhakitiriya uye mavairusi aigona kurarama mumitambo yemasero emasero pasina kuparadza masero emuviri. Kuti iwedzere kutsigira mycoplasmas se causative agent / antigen, muna 1964 maitiro makuru ezvinyorwa zvangu mycoplasma muropa rerheumatoid arthritis varwere uye lupus varwere vakawanikwa, zvichiratidza ikozvino kana kuti utachiona hwepakutanga.
Uyewo yaizivikanwa yaiva 4: 1 yakakwirira yezvinyorwa zve mycoplasma mukati mevakadzi vachiratidza kuwirirana nehupamusoro hwehutatoid arthritis muvakadzi.
Antibiotic Therapy
Kuedza kuratidza kuti kubudirira kwetetracycline therapy kwakatangwa uye kutanga kwakataurwa makore anodarika makumi mana akapfuura naTomas McPherson Brown, MD. Vhiki mbiri mushure mekufa kwaBrown muna 1989, NIH yakakumbira kubatsirwa kwekuchengetedzwa kwechirwere chetracycline therapy ye rheumatoid arthritis yaakanga achitsvaka. Mhedzisiro yekutanga yemakiriniki ekuedzwa, anozivikanwa iye zvino seMira kana Minocycline muRheumatoid Arthritis, akanga achivimbisa uye iyo NIH yakakumbira zvikumbiro zvekutsvakurudza kwe mycoplasma nezvimwe zvirwere zvinotapukira sezvikonzero zvinokonzera zvirwere zvehutatoid muna 1993, uye chidzidzo chepayenzi chemishonga inorwisa mabhakitiriya rheumatoid arthritis muna 1994.
Chigumisiro chekuedza kwechipatara cheMIRA chakati, "Varwere vanotambura neRA kusvika pamwero iye zvino vane chisarudzo chemumwe mushandi wekurapa. Haisi kungoita kuti mishonga inorwisa zviratidzo zvishoma, asi migumisiro yechirwere yaiva shoma uye yakaoma kudarika yakaonekwa kune dzakawanda zvakare rheumatoid treatments. "
"Nei Arthritis?"
Kwemakore ose aya, pfungwa dzinofungidzira mycoplasma senhengo inotapurika inotapukira uye neetetracycline semishonga inorwisa mabhakitiriya yekusarudzwa yakaderedzwa nekushayikwa kwemari yakakwana yekutsvakurudza kwakawanda uye kubva mune zvematongerwo enyika.
"Nei Arthritis?" naHarold W. Clark, Ph.D., mumwe wevanoshamwaridzana naBrown, anoongorora zvirwere zvemukoko, makumi emakore ekutsvakurudza, kutsvaga kurapwa, uye kushungurudzika kwevatsvakurudzi vane mhosva ye anti-mycoplasma therapy yakakanganwa kwemakore 40 ne hurumende uye dzakasiyana-siyana masangano eArthritis. Clark anotenda kuti miitiro yakakanganiswa nokuti kurapwa kwakachengeteka, kusinganzwisisi kunopisidzira kuongororwa kwechiremba kubva apo varwere vaizozodikanwa kuti vasapindira mune zvoutano.
Vanachiremba vakawanda vanoramba vasina chokwadi uye vachiri kuratidza kuti varwere vavo vanorapwa. IArthritis Foundation yakanga ichiita seisina kufara kunyange mushure mokurapa maantibhakitiriya kwaionekwa sokuti yakachengeteka uye inobudirira.
Nheyo yezvehutano wehutano yakashuma ichiti haana kuona kurapwa sekugadzirisa uye kuwedzera kuongorora madhasi uye kushandiswa kwenguva refu kweminocycline kwaidiwa.
Maererano neAmerican College of Rheumatology, "Minocycline inorondedzerwa kune varwere vane zviratidzo zvehupenzi rheumatoid arthritis. Dzimwe nguva inosanganiswa nemimwe mishonga inoporesa varwere vane zviratidzo zvinoramba zvichiitika zvechimiro cheArthritis."
Sources:
Nei Arthritis? Kutsvaga Chikonzero uye Kurapwa kweRheumatoid Arthritis, naHarold W. Clark, Ph.D., 1997
Cannon, Michael. Minocycline (Minocin). American College of Rheumatology. Yakarongwa muna March 2015.