Nhoroondo ye Multiple Sclerosis Treatments
Mishonga-kuchinja marapirwo inzira inokosha yekutanga yekuchengeta MS yako. Kunyange zvazvo vasingakwanisi kubatsira zvakananga zviratidzo zvenyu, vari kushanda kumashure kwezviitiko kuti kuderedza mamiriro ako ezvinhu.
Izvo zvinotaurwa, kune zviverengero zverapi kuti ugoita zviratidzo zvako zvakaoma zveMM. Izvi zvinosanganisira mishonga, maitiro ekuvandudza, uye mazano ekuwedzera, kufungisisa uye reflexology.
Nepo pasina chirwere chekare cheSMS, unogona kurarama zvakanaka nechirwere ichi.
Muzvokwadi, kurarama nekubata naSMS kunogona kungosunungura simba remukati rausina kumboziva iwe.
Denda-Kuchinja Mishonga
Ongororo dzesayenzi pamusoro pemishonga-kuchinjwa kwemishonga yeMS yakawana kuti haingori kuderedza nhamba yekudzokorora kune munhu asiwo kuti yakaoma sei kana yakakomba iyo inodzokazve. Mukuwedzera, zvidzidzo zvinoratidza kuti mishonga-kuchinja marapirwo inoderedza nhamba nekukura kwezvipembenene (sezvinoonekwa paMMIs europi uye / kana mumutsipa weropa) uye kunonoka kufambira mberi kweSMS.
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Iyo Antibiotic yeAgne Inogona Kurapa Mishonga Isolated Syndrome
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Sei Kugadzira Myelin Sheath Ndiyo Kukurukurirana Kukuru muSMS Research
Nemhaka yezvidzidzo izvi, National MS Society inokurudzira zvakasimba vanhu vachangobva kuongororwa kuti vanodzokazve mafomu eMS kuti vatange kurapwa nechirwere chinoshandura zvirwere pakarepo. Inotendwa kuti yekare iwe unotanga, inowedzera mukana wako wokuderedza dambudziko rako rezvirwere.
Ikozvino kune mishonga gumi nemashanu yakagamuchirwa neUnited States Food uye Drug Administration (FDA) yekurapa maitiro ekudzokazve kweSMS (vanhu vane MS re-reping-remitting MS uye vanhu vane MS inotanga kufambira mberi kana kuti yechipiri vanoramba vachidzokazve). Imwe yemishonga iyi inobvumidzwawo kune vanhu vane maZimbabwe anonyanya kufambira mberi (Ocrevus) uye imwe inobvumirwawo kune MS-secondary (Nvantrone).
Injections
Kune mishonga masere inoshandiswa kana iri mumusumbu (intramuscular) kana pasi peganda kusvika mumafuta ako (subcutaneous). Mishanu yemishonga iyi inopironhera uye inosanganisira:
Interferons ndiwo mapuroteni anowanzobudiswa nehutachiona hwemunhu mukutarisana nehutachiona hwehutachiona. Zvinotendwa kuti kune vanhu vane MS, interferon mishonga inogadzirisa mafungiro omunhu, zvichiita kuti kuderedzwa kwezvitsotsi zvinotungamirirwa ne myelin mukati mehupi hwomunhu nemutsipa wepelinha. Myelin inoputira nerve fibers uye, kana yakakuvara kana kuparadzwa (iyo inowanikwa neMS), mitsipa haigone kutaurirana.
Interferon mishonga inowanzochengetedzwa zvakanaka asi inogona kukonzera marwadzo kana kubwinya panzvimbo yeganda apo mushonga unorirwa. Mukuwedzera, vamwe vanhu vanoona zviratidzo zvakadai sechirwere-ichi nemhando iyi yekurapa, kunyange zvazvo izvi zvinowanzoita zviri nani nenguva.
Zvichienderana ne-interferon chaiyo iwe uri kutora, chiremba wako anogona kutarisa basa reropa (sechiropa kana kuongorora masero emuropa) kana kukubvunza mibvunzo pamusoro pezvakaitika kare mune zvechiremba usati wazvinyora.
Semuenzaniso, chiremba wako angabvunza kana iwe une nhoroondo yekuora mwoyo-iyo inogona kukuvadza pane interferon therapy.
Mamwe mairi maviri emishonga inorapa zvirwere-kugadzirisa zvirwere ndeyeCopaxone uye Glatopa (inowanzoita, iyo inodhura mari yeCopaxone). Kungofanana ne-interferon therapy, masayendisiti haasi kunyatsoziva kuti Copaxone kana Glatopa inoshanda sei, asi inofungidzirwa kuti mishonga iyi inofanana neprotini inoumba myelin, pakupedzisira inosvitsa maitiro ezvirwere zvekudzivirirwa kwezvirwere zvekuzvidzivirira maeelin chaiwo.
Chimwe chikamu chechikamu cheCopaxone neGlatopa ndechekuita panzvimbo yejojo, kufanana ne-interferon therapy. Kupindira majekiseni masayiti uye kushandisa compress yakasvibirira usati wajowa inogona kubatsira mukudzikisa maitiro akadaro.
Uyewo, inenge 16 muzana yevanhu vanotora Copaxone kana Glatopa vanoona mushure mekuita majoka zvinogona kuita kuti zviratidzo zvinotyisa zvive sekumhanya kwemwoyo kana kuti kunetseka. Mashoko akanaka ndeokuti zviratidzo izvi zvinowanzopera mukati maminitsi gumi nemashanu uye hazvive nemigumisiro yenguva refu.
Imwe mishonga inorwara-inogadzirisa mishonga ndeye Zinbryta (daclizumab).
Iyi mishonga inonzi anti-antibody inopesana nea molecule inonzi CD25 pane T-cells, iyo inokonzera kupinda-masero masero mumuviri wako wezvirwere. Zinbryta inotendwa kuti inoderedza mishonga yeMEM kuburikidza nekuderedza nhamba yeT-seli mumuviri unozivikanwa kurwisa myelin muSMS. Zinbryta inopiwa kamwe chete pamwedzi, pasi peganda. Nemhaka yekuti inogona kukonzera zvakakomba, zvinetso zvehupenyu zvinotyisa zvehupenyu uye zvinetso zvehutachiona-zvine chokuita nehutachiona, Zinbryta inogona kungorongerwa kuburikidza nepurogiramu chaiyo.
Oral Therapies
Kune mazano mashanu emuromo weSMS chirwere-kugadzirisa kurapwa, iyo ndiyo nzira yakanaka yevanhu vasingakwanisi kubvumira zvirwere kana vanhu avo MS avo vari kuramba vachifambira pasinei ne interferon therapy uye / kana Copaxone.
Gilyena (fingolimod) ipiritsi inotorwa kamwe chete pazuva. Inonyanya kushanda nekudzivirira mamwe masero ezvirwere zvekudzivirira kubva mumuviri weLymph nodes. Sezvo T-masero akabatanidzwa mune lymph nodes, havagoni kupinda muuropi uye musipinha uye naizvozvo vanoita zvipembenene .
Pane huwandu hwemigumisiro inobatanidza naGilyena semusoro wemusoro, chirwere, chirwere, nekurwadziwa shure.
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Chii chiri Copaxone Pakupedzisira-Kusagadzikana Kugadzikana?
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Zvinyorwa paGilenya Zvisiri Kuva Ikutanga MS Oral Therapy
Gilyena anogonawo kukonzera zvinetso zvakakomba zvakanyanya sekusaona zvakanyanya, zvinetso zvokufema kana zvechiropa, uye zvirwere. Pamusana pekugona kweGilyena kukonzera kuderedza mwoyo, kutarisa kwemaawa matanhatu mushure mekunge muzana wekutanga unotarisirwa munzvimbo yekuchengetedza utano.
Imwe mishonga inonzi MS ndeyeTecfidera (dimethyl fumarate) -piritsi inotorwa kaviri zuva rega rega. Iyi mishonga inobatsira nzira mumutumbi iyo inowanzoshandurwa apo masero akasimbiswa. Mune mamwe mazwi, inobatsira kuchengetedza masero, kunyange kunyatsoita kuti izvi zvinoshanda mumunhu ane MS hazvina kujeka.
Matambudziko anowanzoitwa neTecfidera ari kuputika, kusuruvara, kuora, uye kurwadziwa kwepamu. Migumisiro yakaipisisa yakaipa inosanganisira chirwere chakakomba chinokonzerwa nehutachiona, kukudziridza kwekufambira mberi kweiiiiiiiiiiiiiiiiiiiiiiiiiiii ( ii inotyisa hutano hwehutano), uye kuderedza kwemashure evanhu vane utachiona.
Aubagio (teriflunomide) inotorwa kamwe chete zuva nezuva uye inogona kukonzera misoro, bvudzi kudonha, chirwere, chirwere chekushaya ropa, kana kusangana kwechiropa cheropa. Aubagio inoshanda nekudzivirira zvirwere zvemuviri, saka zvinokwanisa kutarisa vanhu kune zvirwere.
Sezvo Aubagio inogona kukonzera kusakundika kweropa, chiremba wako achaongorora zvirwere zveropa rako musati watanga mishonga uye nenguva nenguva pashure. Aubagio iriwo chirwere chepamuviri X zvinodhaka, saka hazvigone kushandiswa apo mukadzi ane pamuviri kana kuti ari kuronga kuti ave nepamuviri.
Infusions
Lemtrada (alemtuzumab) inoshandiswa mishonga yemishonga inoshandiswa neMMS yakapiwa mazuva mashanu mumutsara uye mazuva matatu mushure rimwe gore gare gare. Pamusana pekuti kune dzakawanda dzeAIDS dzinonyeverwa dzakabatana naRemtrada, inogona kupiwa chete kuburikidza nehurongwa chaiwo uye inogadzirirwa vanhu vane MS avo vasina kukwanisa kugadzirisa mishonga miviri kana yakawanda yemishonga-kuchinja.
Chimwe chinokonzera mishonga-inogadzirisa mishonga ndeNovantrone (mitoxantrone), chemotherapy yemishonga inopiwa mwedzi mitatu ipi neipi. Mukuwedzera pakurapa maitiro eWS, mitoxantrone inogona kushandiswawo kubata mushonga wechipiri weSMS . Mitoxantrone inogona kukonzera mwoyo kukuvadza, saka inogona kupiwa chete nhamba shoma yenguva. Izvo zvave zvakabatanidzwawo nekugadzirwa kwemukanwa myeloid leukemia (AML).
Chimwe chechitatu chakabatanidza mushonga wemishonga yemishonga yaSMS ndecheTysabri (natalizumab) , iyo inopiwa mazuva makumi maviri nerimwe. Inogona kugadziriswa chete mumugwagwa unogamuchirwa muchengeti wepamusoro nekuda kwengozi yekuvandudza hupenyu hukuru hwehutukurepaukopathy (PML) -hutachiona hwehutachiona hwakakonzerwa neJC virus .
Ocrevus (ocrelizumab) ndiyo itsva yeAIDS inobvumirwa neCDA, yakagamuchirwa kuti vose vadzoke zvakare MS uye primary progressive MS (yekutanga). Inopiwa sechikamu chemwedzi mitanhatu.
Sezvinoita munhu anonyanya kushandiswa, anonzi Ocrevus anosungira ma molecule anonzi CD anonzi CD20, zvichidaro achideredza nhamba yemasero eB muropa remunhu. Kunze kwemasero eT, masero eB mamwe maitiro ezvirwere zvekudzivirira masero ezvitendi anotenda kuti inobatsira mukurwisa kwangu uye kurasikirwa kwangu.
Inouya Kurapa
Mashoko akanaka ndeokuti masayendisiti ari kudzidza zvakanyanya nezveSMS zuva rega rega, izvo zvinorevawo kuti inoveli, zvirwere zviri nani zviri kubuda. Zvimwe zvinogona kupiwa mishonga (semamwe mishonga inokonzerwa nemarokisi) iri muzvikamu zvekutanga zvekudzidza. Zvimwe kurapwa, sezvakaita stem cell transplantation uye estriol , zvinopesana zvikuru-kunyanya nokuti hakusi masayenzi makuru ezvesayenzi kusimudzira kushandiswa kwavo.
Pakupedzisira, imwe nzvimbo yekutsvakurudza ndeyekuita kwekudya mune MS, kusanganisira vitamin D supplementation uye gutakiti mabhakitiriya . Kunyange zvazvo pasina kudya kwakakwana (kufanana neKudya kweK Swank) iyo vanhu vane MS vanofanira kunyatsotevera, chikafu chakawanda chehutano chakakosha mufiber uye chakanyanya mumafuta chinokurudzirwa neNational MS Society.
Kurapa Zviratidzo
Kunyange zvazvo zvakakosha kuva nemishonga inogadzirisa zvirwere zveWS yako, zvinokoshawo kuti uwedzere kunyaradza nekushanda kwako. Kutaura zvazviri, kurwisana neSMS inzira yezuva nezuva yevanhu vakawanda, vachida hurongwa hunofungisisa hwekuti ungakwanise sei kutarisira zuva rakanakisisa pasi pekurema kwekukwanisa kwako.
Mashoko akanaka ndeokuti kune marapirwo akakwana ekubatsira munhu ane MS kana mudiwa wavo kunzwa zvakanaka uye kutarisira kusanzwisisika kana kutakura zviratidzo. Aya mazano anosanganisira:
- Mishonga
- Lifestyle Habits
- Maitiro ekuvandudza
- Mishonga inobatanidza
Chimwe chiratidzo chinonyanya kukanganisa vanhu vakawanda vane MS ndechokuneta-kana zvose-zvakapoteredza, kupererwa kwechisimba zvinogona kuita mabasa akajeka sekunge akapfekedzwa mangwanani kana kuisa pfungwa pane firimu yakaoma uye isingafadzi. Asi pane nzira dzakawanda dzokurwisana nayo, kusanganisira:
- Zuva roga roga aerobic basa rinongororwa kuzvido zvako nekubatsirwa nechiremba wepanyama
- Mind-body therapies like yoga
- Utano hwakanaka hwekurara sekuchengeta kuchengetedza kwakafanana kurara zuva nezuva
- Kudzivisa kupisa
- Mishonga seSymetrel (amantadine) , Provigil (modafinil) , kana Ritalin (methylphenidate)
Kungofanana nokuneta, pane zvakasiyana-siyana zverapi zveimwe zviratidzo zvine chokuita neMS. Semuenzaniso, kubatanidza kurapwa kwehutano kunogona kushandiswa kurapa marwadzo akanangana neMEMS sezvinoita mishonga yakafanana negabapentin nemarwadzo ane chirwere chendangariro uye musumbu dzinozorodza marwadzo ane chokuita nemisisipo ( spasticity ).
Kuona nyanzvi kunogona kubatsirawo kutarisira zviratidzo zvako. Nyanzvi yehuroyi kana gynecologist inokwanisa kukwanisa kupa kana kupa mishonga yekutarisa kusagadzikana kwepabonde kweSM-yechirwere, maererano nekusavhiringidza kwe erectile mumarume kana kuderedzwa kwevakadzi / clitoral sensation kuvakadzi. Imwe nyanzvi yezveuropiyo inogona kubatsira munhu ari kurwisana nekusaziva kusagadzikana . Kune vanhu vane MS vanoda mazano ekufambisa maitiro, mutapi wepanyama uye wepamberi anogona kubatsira mukuwedzera hurumende uye kushanda mukati memba yako uye kubasa.
Shoko Rinobva
Edza kuva nemoyo murefu sezvaunoita iwe neboka rako rezvehutano hweM MS kuti muve nemhando yakanakisisa yerapa regimen-kuenzanisa kwakanaka pakati pekudzikisa pasi MS yako nekuderedza migumisiro yechirwere uye kuwedzera manzwiro aunoita. Yeuka MS ndiyo chirwere chinoshamisa, saka izvo zvinoshanda kune shamwari kana mudiwa zvingasava zvakanaka kwauri.
Uyewo, sezvo chirwere chako chichifambira mberi kana chichivandudza mushure mekudzokazve, zviratidzo zvako uye kurapwa kwekutora zvinogona kuchinja. Edza kuramba uchichinja uye utaurire zvaunofunga uye zvinetso zvako neurologist yako. Ramba uchiramba wakasimba pane yako MS rwendo.
> Sources:
> Bloomgren G et al. Ngozi ye natalizumab-inofambidzana inofambisa multifocal leukoencephalopathy. N Engl J Med . 2012 May 17; 36620): 1870-80.
> Burness CB & Deeks ED. Dimethyl fumarate: kuongororwa kwekushandisa kwayo kune varwere vane kudzoka-remitting multiple sclerosis. CNS Zvinodhaka . 2014 Apr; 28 (4): 373-87.
> Fazekas F et al. Ko fingolimod (Gilyena) fir muchirongwa chekurapa chinonyanya kushandiswa-kuregera multiple sclerosis? Front Neurol . 2013; 4: 10.
> Lycke J. Monoclonal antibody mishonga yekurapa kwekudzokazve-remitting multiple sclerosis: kusiyanisa nzira nemagariro ekurapa. Ther Adv Neurol Disord . 2015 Nov; 8 (6): 274-293.
> National MS Society. Zvirwere-Kuchinja Kurapa kweMS .
> Namjooyan, F., Ghanavati, R., Majdinasab, N., Jokari, S., & Janbozorgi, M. (2014). Zvishandiso zvemishonga inobatanidza uye yakasiyana-siyana mu multiple sclerosis. Nyaya yeChechi Complementary Medicine , Jul-Sep; 4 (3): 145-52.