Targeting Myelin-Inogadzira Maseku Ndeimwe Chimwe Chete mu MS Therapy
Mazuva ano kurapwa kwema multiple sclerosis kunowanikwa mumuviri womunhu. Kunyange zvazvo vakawanikwa vachideredza nhamba uye kusimba kweSMS zvakare, hapasi mushonga we MS, saka vanhu vanogona kuramba vachiwedzera kukuremara sezvo chirwere chinopfuurira.
Asi iye zvino nyanzvi dziri kuongorora kurapwa kunotarisa myelin-kupfeka kunodzivirira kwakakomberedza nerve fibers yakaipisisa mu MS.
Ngatinyatsoongororei basa re myelin mu multiple sclerosis, uye kuti kuigadzirisa kunogona kudzorera sei maitiro emhepo uye kunonoka kana kuti kunyange kumisa MS munzira dzayo.
Myelin's Function mu Multiple Sclerosis
Mune munhu ane utano, masero emasero anotumira pfungwa kune mumwe kune imwe fiber ine tsvina yakabatanidzwa nemutsara wesero. Aya maitiro mashoma anonzi axons uye akakomberedzwa namafuta, machena sheath anonzi myelin. Kushumira sekudzivirira kana kuchengeta chifukidzo, myelin inobvumira mafungiro emagetsi kuti afambe nokukurumidza uye kubudirira.
Mune multiple sclerosis , muviri wemunhu unodzivirira myelin (uye pakupedzisira inonzi axonswo) muuropi dzavo uye / kana musipinha. Kudzokororwa kwakaitwa maelin pakupedzisira kunotungamirira kukura. Apo myelin inenge yashaiwa simba, mafungiro emagunha haagoni kuendeswa zvakanaka-anokwanisa kufamba zvishoma nezvishoma kana kwete zvachose. Pakupedzisira, axons inopera (kurasikirwa nehutano hwavo hwekushanda) semugumisiro wekusarura kwemaelin kusingaperi, zvichiita kuti mutsara wesero kufa.
Zvichienderana nepamusoro pepakati yenheyo system myelin inorwiswa, zviratidzo zvakadai sekuvhiringidzika kwemanzwiro, zvinetso zvekuona, kushevedza, uye zvinetso zvechirwere zvinotanga kuratidza. Ichi ndicho chikonzero zviratidzo zveSMS zvakasiyana zvakasiyana kubva kune mumwe munhu kune mumwe, sezvo nzvimbo yekurwisa kwangu inoparadzaniswa mukati memutambo mukuru wemagetsi.
Mukuwedzera kune zvinowanikwa nzvimbo dzekudzivirira zvirwere zvemuviri muuropi uye musana wemagunha, nguva yekurwisa uku haisati yagadziriswa-kunyange, nyanzvi dzakaziva zvingaita zvinokonzera kushungurudza kana kuti postpartum period.
Kugadzirisa Myelin: Inotevera Izvo mu MS Therapy
Kunyange zvazvo zvirwere zvemazuva ano -kuchinja maSrapies zvinotarisa kuti vangadzivirira sei zvirwere zvemuviri zvevanhu kuti varwise myelin, ikozvino masayendisiti ari kutarisa kuti myelin inogona kugadziriswa sei kana yakanganisa nemaitiro ezvirwere zvemuviri. Tariro ndeyokuti kana myelin ichigadziriswa, basa rehutano hwemunhu rinogona kudzorerwa, uye munhu wemu MS anogona kumira kuwedzera (kana kuti zvishoma nezvishoma).
Mashoko akanaka ndeokuti zvimwe zvidzidzo zvatove zvichiratidza kuti kuchengetedza nekudzorera myelin inopoteredza midzi inogona kuwedzera musero wemaitiro ekupona. Sezvo uremara hwemunhu hunokonzerwa neWS hunobatanidzwa nehuwandu hwehutachiona hwekufa, nekugadzirisa myelin nekudzivirira masero emagetsi, nyanzvi tarisiro tinogona kumisa kufambira mberi kwehurema kune vanhu vane MS.
Emerging MS Research pamusoro paMyelin Repair
Tsvakurudzo yekudzorera basa uye kugadzirisa myelin mu multiple sclerosis ichiri kunyanya kunyanya. Kunyange zvakadaro, zvinonakidza uye zvinogona kuva danho riri pedyo nekuguma kwe MS kamwe chete.
Chimwe chiduku, chidzidzo chechipiri chechipiri kuYunivhesiti yeCalifornia San Francisco chakaiswa pamusangano weAmerican Academy weNeurology gore negore. Muchidzidzo ichi, kune-over-the-anti-allergies mishonga inonzi clemastine yakaongororwa kuti ione kana iyo inogona kukurudzira myelin kugadzirisa muhupenzi hwevanhu vane MS.
Muchidzidzo ichi, vanhu 50 vane MS uye nhengo dzemaziso eoptic dzakapiwa chirongwa chemuromo kaviri pamusi kana pepiritsi ye placebo kwemazuva 150. Pashure pemakore makumi mapfumbamwe nemashanu kubva mumazuva 150, vatori vechikamu vakashandura kurapwa, kureva avo vakagamuchira clemastine pakutanga vakawana placebo uye vese-versa.
Vatori vechikamu vakaona zvingave zvichiitika, izvo zvinoderedza kutenderera kwemashoko kubva ku retina yeziso kuburikidza nemagetsi e-optic kune maziso anoona-rutivi rweuropi runoshandisa mifananidzo, kana mune mamwe mazwi, inotendeuka chauri kuona mufananidzo chaiwo.
Mhinduro yakaratidza kuti kunonoka kwezvinhu zvakaratidzwa zvakakanganiswa kwakaderedzwa ne 1.9 milliseconds kweziso panguva iyo vanhu vakanga vachirapwa ne clemastine. Ichi kuderedzwa mukuderedzwa kwekushandura kwehutano kunoratidza kuti myelin kugadzirisa iri kuitika pamwe chete nemugwagwa we optic nerve signaling pathway.
Chimwe chivharo chekudzidza ndechekuti chirwere chejekmineine chakanga chiri chakakwirira kudarika chiyero chakanaka chinowanzogadziridzwa, saka hazvishamisi kuti chakaita kuti vamwe vatore mukana.
Zvichida Mishonga yeMyelin-Kugadzirisa Mumaedzo Okutanga
Zvimwe zvidzidzo zvepakutanga zviri kuunganidza varwere kana kuti vari kuenderera mberi maererano nemishonga inogona kubatsira kukurudzira myelin kugadzirisa uye kuchengetedza masero emagetsi mukati memutambo wenheyo.
Semuenzaniso, miedzo yePekutanga 1 (yakakurumidza) inopfuurira kuna Olesoxime uye Guananbenz.
Guanabenz (mishonga yakambotenderwa neDDA yekurapa kukwirira kweropa) yakawanikwa mune zvidzidzo zvemhuka kuti iwedzere kupona kwemasero anogadzira myelin (anonzi oligodendrocytes). Iyo yakawanikwa zvakare kuderedza nhamba yemasero emunununzvi anounganidza muuropi uye musipinha.
Imwe mishonga inonzi Olesoxime , iyo yakatanga kugadzirwa kuti ishandise amyotrophic lateral sclerosis , yakawanikwa kuti inokurumidza kucheneswa kwemasero e-myelin muuropi uye musipinha uye kuwedzera kufungidzira.
Quetiapine is antipyychotic atypical yakawanikwa ichiyeuchidza zvinhu mumufananidzo wemhuka weMS. Inotendwa kuti inodzivirira uye inokurudzira kukura kwemasero emagunha anoita myelin (oligodendrocytes) uye inodzivirira masero ezvirwere anoshanda mu myelin kurwisa mu MS.
Mukuwedzera kune zvinogona kugadzirisa myelin kune vanhu vane MS, sean antipyychotic atypical, inogonawo kuva nehumwe rubatsiro rwekugadzirisa matambudziko emafungiro uye kusuruvara muSMS. Chidzidzo chekutsvaga kwekutsvaga kwekutsvaga maitiro mune zvose zvekudzoka-kuregererwa MS uye MS inofambira mberi iri kuenderera mberi.
Shoko Rinobva
Pfungwa yokuti mishonga inogona kukwanisa kukurudzira myelin kugadziriswa mukati memutambo wenheyo inofadza. Icho chinoratidza kuti uropi hunogona kuzvigadzirisa, kugadzirisa basa remagetsi rakambosvibiswa kana kurasikirwa.
Izvozvo zvichiti, izvi zvose zvese zvichiri zvitsva uye zvakangotanga. Nokudaro pachinakidza kune avo vedu vane MS, edza kuramba uine mwoyo murefu apo kutsvakurudza kunoitika.
> Sources:
> Harlow DE, Honce JM, Miravalle AA. Remyelination therapy in multiple sclerosis. Front Neurol. 2015; 6: 257.
> Nave KA. Kuzvifungidzira uye trophic kutsigira kwenguva refu. Nar Rev Neurosci. 2010 Apr; 11 (4): 275-83.
> National MS Society. (April 2016). Antihistamine Inoratidza Uchapupu hwekusimudzira Myelin Kugadzirisa mu Small Phase II MS Study.
> Zhornitsky S et al. Quetiapine fumarate nokuda kwekurapa multiple multiple sclerosis: chengetedza myelin kugadzirisa. CNS Neurosci Ther . 2013 Oct; 19 (10): 737-44.