Kufamba, kuenzanisa, uye unyanzvi hwemotokari zvinowanzobatwa
Primary progressive multiple sclerosis (PPMS) inokanganisa vakawanda sevanhu vasere vanogara ne multiple sclerosis. Pamarudzi akasiyana-siyana ehutachiona , PPMS inonzi inonzi rarest.
Iyo PPMS inoparadzaniswa sei nemamwe maFomu eSMS
Chimiro chakajairika, chinozivikanwa sekuti relapsing-remitting MS (RRMS) , inoratidzirwa nekurwiswa kwakaoma kutevera nguva dzekuregererwa apo chirwere hachifambi.
Kana ichifambira mberi, munhu anonzi ane chechipiri yekufambira mberi (SPMS) .
PPMS, zvakasiyana, iri kufambira mberi kubva pakutanga. Munhu anonzi aine PPMS haana maitiro akafanana kana kuti anozvezve akabatanidzwa neRRMS kana SPMS. Pane kudaro, zviratidzo zvinomuka zvishoma nezvishoma uye hazvigadziriswi.
Sezvo nedzimwe mhando dze multiple multiple sclerosis, chikamu chePPMS chakasiyana zvikuru, chinokanganisa munhu mumwe nomumwe zvakasiyana. Vamwe vanogona kuve vakaremara mukati memakore mashomanana asi vamwe vanogara vakasimba kwemakumi emakore.
Zviratidzo zvakabatana neSpinal Cord
Mukuratidza zviratidzo, vanhu vanorwara vane PPMS vachawanzova nekutarisana nematambudziko nekuda kwekutambira kweatrophy (kuparara nekutsvaira) kwemutsipa wespelinha. Iyo inozivikanwawo sekufambira mberi kwekuita myelopathy, zviratidzo zvinogona kusanganisira:
- Nzvimbo inowedzera yakawanda inonzi spastic paraparesis, iyo makumbo acho achatanga kuoma, zvichiita kuti kuonekwa kuonekwe uye / kana rhythmic jerkiness
- Kushaya simba kana kutadza kune rumwe rutivi rwemuviri, unozivikanwa se spastic hemiparesis , izvo zvingakanganisa makumbo, maoko, kana maoko
- Dzidzira kusawirirana (yakaderedza simba rekuita basa)
- Kushungurudza uye kushayikwa kwemisumbu kuwirirana ( ataxia )
Apo rwonzi rwepelinha runokanganiswa nechirwere, rinogona kukanganisa zvinopfuura kungofamba.
Iyo inogona kukonzera kuora mwoyo kwepabonde, chikwata, uye maronda. Kuneta kunowanzoshamwaridzana neizvi nemamwe marudzi ose e multiple sclerosis.
Zviratidzo zvakabatana neBongo
Kunyange zvazvo rwonzi rwepelinha ndiro chinangwa chikuru chekukuvara muPMP, uropi hunogonawo kuchinjwa, kunyanya chikamu chinozivikanwa secerebellum iyo inoronga kuenzanisa nekubatana. Iyo inozivikanwa sechifambira mberi cerebellar syndrome (PCS), chirwere chacho chinokanganisa mumwe wevanhu gumi vose vanoonekwa vane PPMS uye vanogona kuratidzira ne:
- Kushungurudzika kwekufambisa maoko zvakanaka nekuda kwekutengesa kwakasimba kwechinangwa
- Kurasikirwa kwematomu tone (hypotonia)
- Kurasikirwa kwemari (gait ataxia)
- Kusakwanisa kurongedza shanduko (dysmetria) apo munhu anogona kupfutidza kana kuderedza zvigadziriswa zvemaoko, gumbo, kana ruoko
- Kusakwanisa kuita nekukurumidza kushandura shanduko ( dysdiadochokinesia ) yakadaro kupinza mubhuruko
Kuvhiringidza uye neurodegeneration inoratidzika seyo nzira huru dzinoita kuti cerebellar uye musana wechipinha zvibatanidzwe nevarwere vePMS.
Kazhinji Zviratidzo zvePPMS
Kunyange zvazvo zvisinganyanyozivikanwi, PPMS inogona kukanganisa dzimwe nhengo dzenheyo yenheyo yakadai seuropi inokonzerwa (iri pakati peuropi nemutsipa wepelinha) uye chirwere chemuviri (muviri mukuru weuropi).
Zviratidzo zvinowanikwa munzvimbo inenge imwe chete yezana yevanhu vane PPMS asi inogona kusanganisira:
- Zvinetso nekumedza ( dysphagia )
- Utsivi, kurutsa, kana kunyorera
- Kukurumidza, kusazvipira kwemaziso ( nystagmus )
- Chiratidzo kuora mwoyo kana kurasikirwa
- Kushaya njere kugadzirisa basa , kusanganisira kurasikirwa kwechirangaridzo, kucherechedza, kutaura kwemazwi, kana kufunga kwepakati
Shoko Rinobva
Kusvikira munguva pfupi yapfuura, pakange pasina mishonga inowanikwa pakurapa PPMS. Zvirwere zvechirwere-zvinoshandiswa zvinodhaka, saRebif neCopaxone, zvinoshanda zvikuru nekuderedza kuputika kunobatanidza neRRMS, asi zvakaratidza kuti hazvina kubudirira mukurapa rudzi rwehutachiona hunoonekwa muPPMS.
Nenguva isipi, zvinhu zvakashanduka. Isu iye zvino tine chirwere chinonzi Ocrevus (ocrelizumab) inokwanisa kubata PPMS pamwe nekudzokazve maitiro ehutachiona. Yakagamuchirwa neU.S. Food and Drug Administration (Mbudzi 2017), Ocrevus inonzi inoshandiswa nemutambo mukuru uye inogona kuvandudza hupenyu hweavo vanorarama nenzira iyi isingawanzove ye multiple multiple sclerosis.
> Sources
> Ohrbach, R .; Zhao, A .; Wang, Y. et al. "Kufananidza Nezvirwere Chiito muSMS uye PPMS mune Mutsara we Multicenter Clinical Trials." PLoS One 2012. DOI 10.1371 / journal.pone.0045409.
> US Food and Drug Administration. "Ocrevus (ocrelizumab) Injection." Silver Spring, Maryland; March 28, 2017.