Kusarudza rudzi rwemuteyo myelogenous leukemia (AML) mumwe munhu ane zvakadai kufanana nezvimwe zvirwere, sepapupa kana kenza yemazamu. Mumuviri wakasimba wekenza yakaita seiyi, kuongorora kunokosha kuti uone kuwanda kwechirwere chacho, uye kubatsira kubatsira kuronga. Zvisinei, panyaya yeukemikemia , vanachiremba vanozoona zviratidzo zvemuviri kubva kumapfupa emafuta ekutsvaira uye biopsy kuti vaone kuti myelogenous (kana myeloblastic) leukemia subtype yakaoma, uye ozoona matanho anotevera.
Chii Chinogadzirisa Chimiro cheMAML?
Masero ose eropa, anosanganisira masero matsvuku eropa, maplatelet, uye masero machena eropa, anotanga sechinhu chimwechete chemasero mufupa remafu . Masero emasero haaikwanisi kugadzira mazamu, kutakura okisijeni, kana kurwisa utachiona, asi anokura kana kuti akakura mumasero eropa anoshanda ese anoita.
Masero emakumbo anowedzera kuva masero masero eropa, anotarisa uye anoita zvishoma se "vakuru" masero avo vachazopedzisira vava nechikwata chimwe nechimwe chekufambisa vanopfuura. Kana kamwe sero reropa rakakura zvakakwana kuti riite basa rayo mumuviri, rinosunungurwa kubva pfupa remapfupa uye kusvika muropa, uko richagara kwehupenyu hwose.
Mumamiriro ekurwa kweukama , kune huwandu hwekuwedzera uye kusunungurwa kwemasero akawanda asina ropa. Masero eukemia anove "akaomerera" pane imwe nhanho yekubatsira, uye anoramba asingakwanisi kuita basa ravakagadzirirwa kuita.
Mhando dzakagadzirirwa necheti yeikudziridza masero anomira pa.
Pane maitiro maviri ekugadzirisa zvirongwa zvekuziva AML subtypes - French-American-British (FAB) system uye World Health Organization (WHO).
IFAB ndiyo iyo inowanzoshandiswa zvikuru. Kuchengetedza AML uchishandisa urongwa uhwu, vanachiremba vachaona masero eukemia avanowana panguva yemafuta emaropa .
Kunze kwekutarisa kuti ndeapi dhigiriro rekusimudza masero aripo, ivo vachaonawo kuti ndeyero yechitini yavanofanirwa kuve kana yakakura.
Icho chati iri pasi apa chinotsanangura iyi purogiramu zvakadzama.
Nei I AML Yangu Yechikamu Chine Basa?
Wako AML subtype inobatsira vanachiremba kuti vagara vataura nezvekurapa, zvibereko, kufungidzira, uye mufambiro wehosha yako.
Somuenzaniso, vatsvakurudzi vakadzidza kuti M0, M4, uye M5 subtypes inobatanidza nechezasi yekuregererwa kwezinga uye haisi pasi pekuteerera kurapwa. M4 uye M5 subtype leukemia masero zvakare anowanzoita masasa anonzi granulocytic sarcomas (zvipembenene zvinowanikwa mumapfupa akanyorova kana pfupa) uye kupararira kune cerebrospinal fluid (CSF).
Kurapa kwakafanana kune vakawanda maitiro ehutachiona ehutachiona kunze kweAppL (M3). Mishonga yakasiyana inoshandiswa kurapa APL, uye inofanirwa kutaridzika inofanirwa kunge iri nani kune dzimwe mhando dzehutachiona hwehutachiona.
IFab Classification System
| Subtype | Zita Rokunyora | Frequency | Cell Characteristics |
|---|---|---|---|
| M0 | Myeloblastic | 9- 12% | Masero emukemukisi anenge asina kuchena uye haana maitiro eesero iyo yaifanira kuva. |
| M1 | AML isina kuchenesa | 16- 26% | Masero myeloid (immete myeloid cells) (kana myeloblasts / "blasts") ndiyo inonyanya kushandiswa mumusero murasi. |
| M2 | AML nekunakisa | 20-29% | Samples ine myeloblasts yakawanda, asi kuratidza kukura kupfuura M1 subtype. Myeloblast ndiyo danho rekupedzisira rekufambira mberi musati madiki masero ari kuita kuti ave mutsvuku kana tsvuku dzeropa, kana kuti platelet |
| M3 | Promyelocytic (APL) | 1-6% | Masero eukenza anoramba achiri mashoma, pakati pe myeloblast uye myelocyte. Yakanyanya-yakagadziridzwa, asi kutanga kutarisa nekuita zvakanyanya seyera chena. |
| M4 | Acute Myelomonocytic Leukemia | 16- 33% | Leukemic masero inosanganiswa ne granulocytic uye monocytic cell types Masefu eukemia ari kutarisa zvikuru semasero eropa machena kupfuura yekutanga, asi achiri kunyanya. |
| M5 | Acute Monocytic Leukemia | 9- 26% | Zvinopfuura 80% zvemasero ndiwo monocytes. Pangave pane zvikamu zvakasiyana zvekukura. |
| M6 | Acute Erythroid Leukemia | 1-4% | Leukemic masero aya masero masero uye maitiro emasero matsvuku eropa. |
| M7 | Acute Megakaryocytic Leukemia | 0-2% | Leukemic masero haana kufanana nemaitiro eeplatelet. |
The Bottom Line
Nokuti masero eukemia anoenda nokukurumidza mumuviri wose, nzira dzechidimbu dzekenza yekupinza hazvishandi. Pane kudaro, vanachiremba vanotarisa panyama uye mazamu emufetera wemasero ako kuti ugozviisa mu subtype. Izvi zvinyorwa zvinobatsira vanachiremba kuti vaone kuti rudzi rwekurapa ruchashanda zvakadini kwauri uyewo rubatsiro kufanotaura zvibereko zvekurapa kwako.
Sources
Aquino, V. "Acute Myelogenous Leukemia" Iye zvino Matambudziko Mukurapa February 2002 32: 50-58.
Hillman, R. naAult, K. (2002) The Acute Myeloid Leukemias. Hematology mu Clinical Practice 3rd ed. New York McGraw- Gomo.
Vardiman, J., Harris, N., uye Brunning, R. "World Health Organization (WHO) Kurongeka kweMyeloid Neoplasms." Ropa October 2002 100: 2292- 2302.