Kuita sarudzo yakasarudzwa pamusoro pe multiple multiple sclerosis (MS) mishonga yekurapa inotanga kuziva kuziva. Mune zvimwe zviitiko, zvisarudzo zvingave zvisingakwanisi pamusana pechigarire chechirwere chako, kuoma kwemararamiro, kana chero mishonga yapfuura yemishonga ingangodaro yave yakasangana nayo.
Avonex (interferon beta-1a) ndiyo imwe sarudzo inowanzotaurwa muzvirwere zvokutanga. Sezvakaitwa nemishonga yose yeSMS, ine zvese zvakabatsirana nezvisina kukwana.
Zviratidzo
Avonex (interferon beta-1a) chirwere chinopindwa muropa chinopa mudziyo wakaderera we interferon uchienzaniswa nezvimwe zvirongwa zvokurapa. Yakagamuchirwa neU.S. Food and Drug Administration muna 1996 kuti ishandiswe kune vanhu vane chirwere chekutanga-chetachiona-inozivikanwa sekudzorera zvakare-kuregeresa MS (RRMS) - kana kune avo vakawana imwe shamhu yeMMS asi vasingakwanisi kugadzirisa zvirongwa zveMMS. .
Kubudirira
Kubva pane nhamba yekuverenga, zvose zvinonzi CRAB zvinodhaka ( Copaxone , Rebif , Avonex, Betaseron ) zvakanyanya zvakaenzana zvakafanana, kuderedza dambudziko rekudzoka zvakare kuvanhu vane RRMS neanenge chetatu.
Pre-market clinic tsvakurudzo yakaratidza kuti Avonex inogona kuderedza dambudziko reM MS rinodzokorora ne 32 muzana kune vanhu vane unyoro kusvika kuongorori RRMS. Zvimwe zviongorori zvemashure emakambani zvakanyanyisa zvinodhaka pakati pe19 muzana uye 38 muzana, (kusiyana kwaro kunogona kutsanangurwa nehutano hwakasiyana hwemiedzo uye / kana vanhu vanoverengera).
Avonex haifaniri kunge isina kunyanya kushanda munguva.
Kune humwe humwe uchapupu, zvisinei, kuti iyo-yakanyanya-dose interferons seRebif inogona kuva yakabudirira mune vamwe. Sezvo zvakadaro, Rebif inowanzomirirwa sechipiri-line treatments kana munhu akawanazve kudzokera zvakare pa Avonex.
Administration
Vanachiremba vazhinji nevarwere vanosarudza Avonex semishonga inotanga kushandiswa kwekutanga nokuti inongoda jekiseni rimwe chete pavhiki kana ichipikisa katatu kusvika kune manomwe inoda mamwe madhiragi.
Chirwere chekare-ye-vhiki chinoderedzawo mararamiro akafanana nemafuta, achibvumira vanhu kutora chishanu musi weChishanu ndokudzoka pamusi wevhiki.
Izvi zvinopa Avonex chisarudzo chakanaka kune vanhu vari kushanda nguva yakazara, vari kutarisira vana vaduku, kana kuti vane nyaya dzinogadzirisa nguva dzavanenge dzisina nguva. Dhipatimendi inowedzerawo kune vanhu vasinganzwisisiki nekuzvidzivirira ivo pachavo. Pane kudaro, nguva dzose kushanya kwehofisi kunogona kugadziriswa (izvo zvingagonesa kurapa kwakanaka, pamwe chete).
Sezvinopesana nedzimwe mishonga inowanikwa pasi pedcutaneously (pasi peganda), Avonex inofanira kupiwa intramuscularly (kazhinji iri mumutsipa wehudyu). Pamusoro pechipfuva, pane zvinowanzova zvishoma kubwinya kana kupfugama panzvimbo yejojo.
Zvakakodzera, chirwere chinofanira kupiwa musi iwoyo vhiki imwe neimwe, kunyange zvazvo inogona kunge yava pedyo nemazuva mashanu kana kwenguva yakareba mazuva gumi pairi kana zvichidiwa.
Migumisiro Yechiri
Zvimwe zvikamu zveAvonex zvakafanana nedzimwewo ma-interferon-based therapies uye zvinogona kuratidzira nezvirwere-kufanana nezviratidzo, kusanganisira:
- Fever
- Chills
- Sweating
- Muscle Aches
- Kuneta
Vose se 61 muzana yevanhu vanotora Avonex vachawana zviratidzo izvi zvinogona kupedza chero kubva maawa 24 kusvika ku 36 paavhareji. Zvizhinji zveizvi zvichapedza nguva, kunyange zvingave zvichitora kwemwedzi mitanhatu kana kupfuura kune zvidimbu zvakasiyana.
Kuora mwoyo kwakave kwakataurwawo kune vamwe, kakawanda mushure mokurapa kwenguva refu.
Kufungisisa nekupikisa
Avonex haina kukodzera munhu wose. Inogona kushandiswa nekuchenjerera mune vamwe vanhu kana kudziviswa zvachose kune vamwe. Kufunga kunosanganisira:
- Vanhu vari Avonex vanofanira kuongororwa nguva dzose kuti vaongorore mavhinga eropa. Avonex inogona kukonzera kukwidzika kwezvinokonzera mishonga iyo inogona kutungamirira kuchiropa kukuvara kana kukundikana. Vanhu vane chirwere chechiropa chisati chavapo kana chirwere chinonzi cirrhosis chingave chisina kukodzera kuVavonex uye inofanira kuongororwa pane imwe nyaya-ne-case.
- Avonex haifaniri kushandiswa nevakadzi vane pamuviri kana kuti vari kuronga kugadzirisa . Kunyange zvazvo pasina kliniki yevanhu inotsvakurudza inowanikwa kuti iongorore ngozi inogona kuitika kumucheche, kuberekwa kwekuberekwa kwakave kwakaratidzwa mumhando dzakawanda dzezvidzidzo zvemhuka. Kuberekwa hakunzwisisi mauri kune (kana kuti achangobva kuve) Avonex.
- Avonex inofanira kushandiswa nekuchenjerera kune vanhu vane kliniki yekuora mwoyo. Kunyange zvazvo zvisiri izvo zvinopesana nemashandisirwo (kunyanya sezvo dambudziko rekuora mwoyo rinowedzera kune vanhu vane MS), rinorayira kuchengetedza kwakasununguka kuve nechokwadi chokuti hupenyu hwomunhu hwomunhu hahuna kupindira zvakanyanya nemishonga.
- Saizvozvowo, Avonex inofanira kushandiswa nekuchenjerera kune vanhu vane matambudziko ekutambura kana matambudziko emwoyo sezvo inogona kuwedzera kana kuwedzera zviratidzo izvi. Muzviitiko zvisingawanzoitiki, Avonex yave ichizivikanwa nekukonzera kugunun'una uye kusagadzikana kwemwoyo kune vanhu vasina nhoroondo yekare kana kuti zvinokonzera ngozi kune zvimwe zviitiko.
Mari yekurapa
Avonex's average price retail range muna 2017 inopfuura $ 6,500 pamwedzi kana anenge $ 81,000 pagore. Inishuwarenzi inowanzobatanidza chikamu chemari yekurapa, kunyange zvazvo copay uye kunze kwehomwe mari zvinogona kunge zvakanyanya. Varwere vanobatsira rubatsiro (PAPs) varipo kuti vabatsirwe nekubhadhara zvinodhaka kana kubatsira kwepa copay kune iyi nemamwe marudzi emishonga isingagumi inosingaperi.
Kuti uwane mamwe mashoko, taura neVatsigiri veVatariri paByonex (muiti wezvinodhaka) pa800-456-2255 kana kushanyira AboveMS.com kuti uwane mamwe mashoko.
> Source
> US Food and Drug Administration. "ZVINHU ZVINOKUDZIDZISA KUZIVA: Avonex (interferon beta-1a) ." Silver Spring, Maryland; yakagadziridzwa muna 2015.