Kuchengetedza uye Zvaunofanira Kutarisa Pakutora Tysabri
Tysabri ndeyevanhu vane mararamiro ekudzorera zvakare maSMS uye inotungamirirwa sekudzivirira (kunopiwa kuburikidza nemuviri wako) kamwe chete mazuva makumi mana. Zvinowanzotaurwa kune varwere vasingatauri kune dzimwe zvirwere zveSMS zvinoshandiswa pakurapa (zvinoreva kuti chirwere chavo chinoramba chichiwedzera kuipa) kana kuti avo vasina kukwanisa kushivirira mamwe mazano e MS, kazhinji kubva mukukuvadza kana kushungurudza madhara.
Ngozi ye PML neTysabri
Dambudziko rakaoma (asi rakashata) rokutora Tysabri ndi PML (progressive multifocal leukoencephalopathy), iyo inogona kuuraya hutachiona hunokonzerwa neJC virus. Vanhu vari pangozi yakakura yekutora PML kana vari kutora mimwe mishonga inowedzera simba ravo rekudzivirira zvirwere mumuviri pavanotora Tysabri. Zvimwe zvinhu zviviri zvinowedzera ngozi zvinowedzera mukana womunhu wekuvandudza PML zvinosanganisira kutora Tysabri kwemakore anopfuura maviri uye / kana kuongorora zvakanaka kune JC virus antibody.
Munhu asina chimwe chezvinhu zvitatu izvi zvinokonzera ngozi ane anenge 1 / 50,000 mukana wokutanga PML apo paTysabri. Asi kana zvinhu zvose zvitatu zvinokonzera njodzi zviripo, njodzi inenge ine 11-13 / 1000. Kana munhu achingoongororwa zvakanaka kune JC virus antibody (hapana zvimwe zvinokonzera ngozi) pangozi yavo yekuvandudza PML inenge inenge 1/1000.
Kuti uone njodzi yemunhu yekuita PML, vanachiremba vachaongorora kuongororwa kweropa kweanoripikisi kune JC virus vasati vasarudza Tysabri nemwedzi mitanhatu apo munhu ari kutora Tysabri.
Kubva pamigumisiro, chiremba achaongorora chikamu chekuwana / kubatsirwa kwekutora Tysabri nemurwere. Mukuwedzera, vanachiremba vachawana MRI (kusiyanisa zviratidzo zvemuMM zviratidzo zvichibva mune ramangwana ramangwana PML zviratidzo) asati atanga Tysabri.
Kuongororwa kwePPL semurwere paTysabri
Somurwere, kana iwe ukatora Tysabri, zvakakosha kusangana nachiremba wako pakarepo kana iwe ukatanga zviratidzo zvinenge zviri maererano ne PML.
Izvi zvinogona kunge zvinonyangadza sezvo zviratidzo zvakawanda zve PML zvinomiririra avo ve MS. Mienzaniso yezviratidzo zve PML dzinosanganisira:
- kupera simba zvishoma pane rumwe rutivi rwemuviri
- clumsiness
- chiratidzo chinochinja
- unhu hunoshanduka
- matambudziko nekufunga, chirangaridzo, uye chinangwa chinotungamirira kukuvhiringidzika
Zvimwe Zvingave Zvimwe Zviitiko Zvimwe uye Manyevero eTysabri
Nzira dzinowanzobatwa dzeTysabri dzinosanganisira
- kuneta
- headache
- hutachiona hwehutachiona kana hutsika hwepfupa
- vaginitis
- chifuva kana kushungurudzwa mumimba
- kuora mwoyo
- chirwere
- mapundu
- kurwadziwa kwepamuviri kana kurwadziwa pamwe chete.
Tysabri inogona kukonzera kukanganisa kwechiropa, iyo inogona kuonekwa neropa rekuongorora. Zviratidzo nezviratidzo zvekukuvara kwechiropa zvinosanganisira kuchena kweganda nemaziso, kuneta kwakanyanya, kusuruvara, uye kurutsa, kana urinhi.
Tysabri anogonawo kukonzera utachiona hwake hwepfungwa, hupombwe, uye meninges. Zviratidzo nezviratidzo zveizvi zvinosanganisira fever, musoro, kusunga kwemutsipa, zvinetso zvekuona, kuvhiringidzika, uye mufambiro unoshanduka.
Pakave nezviitiko zvehutano hwehutachiona hwevatachiona huri muTysabri, vamwe vanoda kurapwa (kunyange kuchipatara). Zviratidzo zveizvi zvinosanganisira mikoko / itching, chills, chizuru, kurwadziwa kwepfupa, kuputika, kunetseka kufema nekuderedza ropa.
Mukuwedzera , vanhu vari kuTysabri vangangodaro vanoita zvirwere uye vanofanirwa kutora matanho ekudzivisa, kusanganisira maitiro akanaka ekugeza maoko uye kudzivisa vanhu vanorwara, kana zvichibvira.
Kuongorora Pasi paTysabri
Tysabri inogona kugoverwa pane imwe nzvimbo yekuisa pasi iyo yakanyoreswa kuburikidza ne "TOUCH" purogiramu. "TOUCH" inomiririra "Tysabri Outreach: Unified Commitment to Health" uye ndiyo chirongwa chakaiswa panzvimbo yekuedza kubata chero zviitiko zvinogona kuitika zve PML mumavambo okutanga, pamwe nekudzivirira.
Kubata paTysabri
Tysabri inofungidzirwa kuva "pamuviri wechikamu C," zvinoreva kuti yakakonzera kukanganisa kumabereki muzvidzidzo zvemhuka, asi kushanda kwevanhu hakuzivikanwi. Tysabri haafaniri kushandiswa nevakadzi vane pamuviri uye vanofanira kumira kwechinguva vasati vaedza kubata (teererai izvi nechiremba wenyu).
Pasi Pasi
Iwe unofanirwa kushanda pamwe chete nechiremba wako kuti usarudze kana Tysabri ari mishonga yakakodzera kwauri. Kana iwe ukasarudza kuitora, iva nechokwadi chekuverenga iyo rerapi yemishonga zvakadzama. Uyewo, iva nechokwadi kuti unokurukura zviratidzo nezviratidzo zve PML, utachiona, kukuvadzwa kwechiropa, uye zvinokonzerwa nehutano nechiremba wako. Iva nechokwadi kuti iwe unofanirwa kutevera zvakare (semuenzaniso 3 mwedzi mushure mekudzivirira kwekutanga), uye kuti vamwe vese vamwe vanachiremba vanoziva kuti uri kutora Tysabri. A
Sources:
Krumbholz, M., et al. (2007). Delayed Allergic Reaction kwa Natalizumab Yakabatana Nekutanga Kuumbwa kwekudzivirira Maitiro Anopesana. Archives of Neurology , 64: 1331-1333.
Polman, CH, uye al. (2008). Chiongorori chisingatariswi, chinokonzerwa ne-placebo-chengeteredzwa ye natalizumab yekudzorerazve multiple sclerosis. New England Journal of Medicine , Mar 2; 354 (9): 899-910.
National MS Society. (2016). Iyo MS Disease-Kuchinja Mishonga .
Rudick, RA, et al. (2006). Natalizumab plus interferon beta-1a yekudzorerazve multiple sclerosis. New England Journal of Medicine , Mar 2; 354 (9): 911-23.
US Food and Drug Administration. Tysabri.
ZVINOKUDZIDZA: Mashoko ari panzvimbo ino ndeongangwa dzekudzidzisa chete. Icho hachifaniri kushandiswa sechinzvimbo chekuchengetedza iwe pachako nechiremba ane chiremba. Ndapota ona chiremba wako kuti aongororwe uye kurapwa chero kupi zvako pamusoro pezviratidzo kana chirwere chechiremba .