Icho chichiri kare kare kuti taudze, asi kurapa kunofadza kunogona kunge kuripo
Kuongorora kweCanada kwakabudiswa muNew England Journal of Medicine inoratidza kuti vanhu vane kliniki yega yega syndrome kune multiple sclerosis (inonzi CIS) iyo inotora antibiotic minocycline inogona kuva nehuwandu hwekuwedzera huwandu hwakawanda hweplerosis.
Zvechokwadi, kune chikonzero chakakura chokutora minocycline sechirwere cheCIS, sezvo iri shoma, iri nyore kutora (iri mishonga yemuromo), uye ine unhu hwakanaka hwekuchengeteka.
Kunyange zvakadaro, inofananidzwa sei nedzimwe zvirwere zvinoshandura zvirwere seBetaseron kana Avonex? Mukuwedzera, chidzidzo chacho chinoratidza kubudirira kwacho chiduku, saka miedzo yakakura inodiwa kuti ione kuti inobatsira sei.
Ngatinyatsoongororei izvi zvinogona kubuda mishonga. Izvo zvingave kana zvisingagone kushanda, kubata "nei" mushure mekuti mushonga unorwisa mabhakitiriya unogona sei kudzivirira kufambiswa kweMS kunonakidza mune zvahwo.
Minocycline seNogona Kurapa kweCIS
Usati wambotora chidzidzo mumushure pekuchera minocycline sechirwere cheCIS, zvakakosha kunzwisisa chii chinonzi kliniki yega yega syndrome kune MS, uye kuti minocycline ingatoonekwa sei sechirwere chinogona kuitwa.
Chii Chinonzi Clinic Isolated Syndrome?
Chirwere chinokonzerwa nehutachiona kune multiple sclerosis, kana CIS, rinoreva vanhu vanoona zviratidzo zve "MS-like" kwemaawa masere makumi maviri nemana, uye zviratidzo izvi zvingaita kana kuti hazvingawirirane nezvipembenene zvakaonekwa paMRI.
Mukana wacho ndeyekuti kunze kwechikamu chekutanga chekutanga, hapana zvimwe zvinyorwa zvinoratidza kuti munhu aimbova zvakare MS zvakare , zvichienderana nenhoroondo yavo kana neMRI yavo (hapana mamwe mavhinga ehutano hweMMS).
Mune mamwe mazwi, munhu anenge asina hutano hwakakwana hwehutachiona kana radiographic kuti awane chirwere cheSMS.
Imwe dambudziko nekuongororwa kweCIS ndechokuti chiremba anofanira kusimbisa kuti "zviratidzo zveMMS-semunhu" (somuenzaniso, optic neuritis ) zvechokwadi nemhaka yekurasikirwa kweyanguel-chidziviriro chekudzivirira pamusoro pemasero emagetsi muuropi uye musipinha.
Izvi zvingada kuedza kuongororwa kwakafanana nekugadziriswa kwemakumbo kana kukanganiswa , uyewo kutonga kune dzimwe mamiriro ezvinhu emuMM-kutengesa sehutachiona kana zvimwe zvirwere zvinokonzerwa nemuviri (semuenzaniso, systemic lupus erythematosus).
Izvi ndizvo zvinogona kuita zvinhu zvinonyangadza, sezvo nyanzvi yezvehutano inofanira kushandisa mutongo wake kuti aone kana munhu ane chirwere chekuchengetedza chirwere chepachivande kune MS anofanira kupiwa mushonga nechirwere chinoshandura zvirwere.
Kazhinji, kurapa kunokurudzirwa kana munhu ane CIS ane MRI iyo inoratidza zvipembenene zvakaratidzwa mu MS.
Chii Chinonzi Minocycline?
Minocycline is antibiotic, saka ndiyo mishonga inoshandiswa kudzivirira kukura kwebhakitiriya. Inoshandiswa kurapa huwandu hwehutano hwakafanana nehutachiona, kana mapapu, zvepabonde, uye zvirwere zveganda.
Unogona kushamisika kuti kutora minocycline kunogona sei kubatsira mumwe munhu pangozi yekuvandudza MS. Zvakanaka, masayendisiti akawana minocycline kuti iite anti-inflammatory properties, saka inogona kugadzirisa masimba evanhu, kunze kwekudzivirira kupararira kwebhakitiriya.
Zvinogona kuti nzvimbo inopesana nokuputika kweminocycline inobva pakukwanisa kwayo kuchinja mabhakitiriya mumatumba evanhu sezvo mabhakitiriya anoita basa rinokosha pakuronga masimba evanhu.
Minocycline inofanirwawo kuti inodzivisa kubuda kwemamwe maune immune system masero anokonzera myelin muuropi uye musipinha.
Pakupedzisira, tsvakurudzo inoratidza kuti minocycline inogona kudzivirira masero emagetsi nekudzivirira kufa kwavo. Iyi ndiyo imwe nzira iyo inogona kubatsira avo vane CIS.
Chidzidzo Ichi Chakazivisei?
Mumakore mana, 142 vatori vechidiki neCIS vanobva mumakirini 12 akasiyana-siyana eCanada MS vakashandiswa kuti vawane 100mg yeminocycline kaviri pazuva kana placebo.
Vose vevatori vechikamu vakanga vaona zviratidzo zvavo zvekutanga zveCIS-mukati memazuva 180 vasati vatanga kudzidza. Ruzhinji rwevatori vechikamu vaiva vakadzi (68 muzana), uye izvi zvinowanzoitwa neCIS (zvinowanzozivikanwa nevakadzi), nevhareji yemakore iri makore anenge 36.
Chidzidzo chacho chakanga chiri mapofu-kureva, zvisingarevi vatori vechikamu kana vaparidzi vakaziva kana vari kuwana minocycline kana placebo.
Vatori vechikamu vakaramba vachipora mushonga (kana kuti placebo) kusvikira vasati vawana vane MS kana kusvika mwedzi 24 mushure mokunge vatanga kutora minocycline (kana placebo).
Mhinduro dzakaratidza kuti mumwedzi mitanhatu mushure mekunge vatori vechikamu vatanga kutora minocycline, 33 muzana vakagadzira MS, vachienzanisa ne 61 muzana yevatori vechikamu vanotora nzvimbo iyo. Ichi chikafu chinopesana chinokwana makumi maviri nemakumi mapfumbamwe.
Mushure mekugadzirisa huwandu hwezvinyorwa zvekutanga zveM MS, musiyano wakaenda kusvika 18.5 muzana, izvo zvichiri kuomesa. Chikonzero chekugadziriswa uku ndechekuti nzira yekuongorora huwandu hweSMS yakarongedzwa munguva yekudzidza uku. Maererano nekuvandudzwa kweMcDonald 2010, munhu anogona kuongororwa ane MS kana vane MRI uchapupu hwe MS mavhinga europi, kunyange dai vasina zviratidzo zvine chokuita neavo.
Kunyange zvazvo mukana wekutendeuka kubva kuCIS kusvika kune MS wakanga wakaderera kune avo vakatora minocycline pamwedzi 6 kana vachienzaniswa ne placebo, zvinosuruvarisa, izvi hazvina kuchengetwa pamwedzi makumi maviri nemana.
Minocycline Inofananidzwa Sei Neimwe Mishonga yeCIS?
Migumisiro yenyaya ino yakafanana nedzimwe mishonga inoshandiswa kuCIS seBetaseron (interferon beta-1b), Avonex (interferon beta-1a), uye Aubagio (teriflunomide), zvinoreva pamwedzi 6, idzirapa dzose dzakaratidza dambudziko rakaderera rakafanana rekukura MS.
Zvisinei, hapana musoro kuenderera mberi kuongororwa kuongorora minocycline kune chimwe chezvinyorwa zvataurwa pamusoro apa, saka zvichiri kunyanya kutaurira kuti inofananidza sei.
Zvose mune zvose, nepo minocycline inofadza semari inodhura uye mishonga yakachengeteka, chidzidzo chekuongorora kubatsirwa kwayo sechirwere cheCIS chakanga chiri chiduku uye chaiva nezvimwewo zvishoma zvine chokuita nekudzidza.
Zvidzidzo zvikurusa zvichiri kudiwa kuti zvione ichi ichi chinyatsokosha uye chinoshanda mushonga.
Pane Mucheto Kutora Minocycline Here?
Iwe unogona kunge uchishamisika kana kune dambudziko rekutora minocycline, sekunge kana kwete yakachengeteka kana kuti kunokonzera kusagadzikana. Izvi zvinokosha nokuti kunamatira kaviri pamusi mishonga inogona kuva yakaoma zvakakwana, uye kana ichiita kuti uchinzwa usine hukama, kuomerera uku kunova kwakaoma zvikuru.
Nzira dzakawanda dzinowanzoitika dzinogona kuitika neminocycline dzinosanganisira:
- Diarrhea
- Uchechezi kana kuchena
- Headache
- Dental discoloration (kufanana nekumera kwemeno uye muromo)
- Kunzwa kwezuva (unogona kuwana zvakanyanya kudarika kupisa kwezuva)
- Zvirwere zvinokonzera fungal (somuenzaniso, zvemuviri mbiriso zvirwere)
Panewo zvimwe zvisingaiti asi zvinetso zvakakomba zvinogona kuitika neminocycline sepseudotumor cerebri . Mukuwedzera, minocycline inopesana nekamuviri uye mukuyamwisa, uye inogona kuderedza kushanda kwepiritsi yekuberekwa kwepabonde.
Zvisinei, pasinei nemigumisiro iyi yakataurwa, minocycline ine huwandu hwakanaka hwekuchengeteka uye vanhu vanowanzoita zvakanaka nazvo.
Zvechokwadi, semishonga chero ipi zvayo, unoda kutaura zvakanyatsonaka nachiremba wako pamusoro pezvinogona kuisa njodzi yekutora minocycline pamwe nekubatsirwa kwayo (kana yakambobvumirwa kushandiswa muCIS), pamwe nekuongorora zvose zvingangova nemigumisiro.
Shoko Rinobva
Kunyange zvazvo migumisiro yekudzidza iyi inofadza, inongova chiito checheche mukutungamirirwa nekudzivirira MS kubva pakuitika kune vanhu vanoonekwa kuti vane zviratidzo zvokutanga. Zvimwe zvidzidzo zvinodiwa paMinocycline, kunyanya sezvo kutsvakurudza kuchiri kusanganiswa pamigumisiro.
Semuenzaniso, kumwe kuongorora kwakaratidza minocycline yakapiwa neBeta-Seron haina kukonzera zvirwere zvekutarisa kune vanhu vanezve kudzoka-remitting multiple sclerosis. Iyi tsvakurudzo inopesana inongoratidzira kuti zvimwe tsvakurudzo dzinoda kuitwa musati maitiro eurologist atanga kupa varwere vavo vane MS tetracycline antibiotic.
> Sources:
> Marcus JF, Waubant EL. Mavandudziro pamakiriniki akazvimiririra chirwere uye chirwere chekuongorora chinonzi multiple sclerosis. Neurohospitalist . 2013 Apr; 3 (2): 65-80.
> Metz LM et al. Chiitiko cheminocycline mune chirwere chetachiona chega che multiple sclerosis. N Eng J Med. 2017 Jun 1; 376 (22): 2122-33.
> Multiple Sclerosis Society of Canada. (May 2017). Minocycline yeKliniki Isolated Syndrome (CIS) FAQ.
> Sørensen PS et al. Minocycline yakawedzerwa kune subcutaneous interferon β-1a mune multiple sclerosis: randomized RECYCLINE kudzidza. Eur J Neurol. 2016 May; 23 (5): 861-70.