Inobatsira Sei Zinbryta uye Ndeipi Inogona Kukonzera Mikana?
MunaMay 2016, United States Chakudya neDrug Administration yakabvumira chirwere chinoshandura chirwere chinbryta (daclizumab) chekurapa kudzoka-kugadzirisa MS .
Zinbryta mishonga inopiwa pasi peganda vhiki dzose mavhiki mana. Zvinotendwa kushanda nekuvhara nzvimbo yekusungira pane interleukin-2 (IL-2) -a molecule muzvirwere zvemuviri zvinoita kuti T-cells ako ashandise.
Nokudzivirira receptor pane interleukin-2, masero eT haabvumirwi kurwisa myelin sheath muuropi dzako uye musipinha.
Zinbyta inogonawo kushanda nekuwedzera masero muzvirwere zvemuviri zvomuviri zvinonzi masheya ehupenyu, anouraya masero anonzi T anogadzirirwa kurwisa myelin sheath.
Sayenzi Inopinda Zinbryta
Mune chidzidzo chikuru muThe New England Journal of Medicine, vatendi 1841 vanezvekudzorera-MS vakagadziriswa vakashandurwa kuti vawane kana chirwere cheZinbryta (daclizumab) vhiki ina dzose kana Avonex (interferon β-1a) vhiki nevhiki kwemakore anoda kusvika matatu.
Mhinduro dzakaratidza kuti vatori vechikamu avo vakagamuchira Zinbryta vane 45 muzana vashoma MS vanodzokorora gore kune avo vakagamuchira Avonex.
Mukuwedzera, nhamba yezvitsva kana kuti kuwedzera kwechirwere cheM MS paMRI yaiva makumi mashanu kubva muzana muzana kune avo vakagamuchira daclizumab, vachienzaniswa nevaya vaibatwa neAvonex.
Mune imwe dzidzo muLancet , vanenge vatori vechikamu vanosvika mazana 600 vachidzoka zvakare-remitting MS vakanga vasina randomized kuti vagamuchire chirwere chepasi cheZinbryta (150mg), nhamba yakakwirira yeZinbryta (300mg), kana injection ye placebo.
Vatori vechikamu kana vatsvakurudzi vakaziva kuti chirwere chinopiwa chii-ichi chinonzi chidzidzo chekupeta-mapofu uye chinodzivirira zvigumisiro kubva pakuva nehanya. Vakatora vakagamuchira majekiseni vhiki yega yega kwegore.
Migumisiro inoratidza kuti kana ichienzaniswa ne-placebo, chirwere chepasi cheZinbryta (150mg) chakaderedza kuwandisa kweSMS kubudikidza ne 54 muzana, uye muzinga wakareba (300mg) yakaderedza kuwedzerwa kweM MS kuburikidza ne50 muzana.
Saka, iyo yepamusoro uye yepamusoro dose yakapa mitezo yakafanana yakafanana, ichi chikonzero nei muyero wakadzika unoshandiswa kuderedza migumisiro yakaipa.
Zvinogona Kukonzera Kuipa kweZinbryta
Kufanana nemishonga yose, Zinbryta inotakura mikana yemigumisiro yakaipa, dzimwe kunyange zvichida kutyisa upenyu. Izvi zvinorondedzerwa senjevero yebhokisi uye inosanganisira:
- chiropa chakakomba chinogona kuuraya
- colon kutuka
- kugadzirwa kweganda
- lymph nodes kuwedzerwa
Zvimwe zviyeuchidzo zvezvinodhaka zvinosanganisira zvinogona kukonzerwa nezvinokonzerwa nemagetsi, uye kuwedzerwa njodzi yekuwana zvirwere uye kushushikana, kusanganisira kuzviuraya.
Maererano nemigumisiro yakaipa yakafanana, iyo inorondedzerwa muchidzidzo ichifananidza Zinbryta kune Avonex inosanganisira:
- kutonhora zviratidzo
- kumusoro kupumhidza chitachiona kana kuti bronchitis
- eczema, rash, kana imwe yeganda
- furu
- kurwadziwa kwehuro
- akawedzera lymph nodes
Zvimwe zvinowanzotaurwa zvakaipa zvinosanganisira kuwedzera kwechiropa chechiropa uye kuora mwoyo.
Pamusana pezvakakonzerwa nemigumisiro iyi yakaipa, Zinbryta inongorumbidzwa chete kune vanhu vane MS vasina kupindura kune maviri kana kupfuura mamwe maSrapies.
Mukuwedzera, inogona kungorondedzerwa pasi pecurogiramu inonzi Risk Assessment nekugadzirisa hurongwa (REMS). Izvi zvinoreva kuti nyanzvi yako yezveuroyoti inofanirwa kubvumidzwa kukubata iwe neZinbryta.
Chinangwa chepurogiramu ndechekuti uve nechokwadi chokuti nyanzvi yako yezveuroyoyo inotarisa iwe nekuda kwezvinoitika zvinorwadza, sekuona nguva nenguva chiropa chekuita ropa.
Shoko Rinobva
Zvinokurudzira apo mushonga mutsva waSMS worwere-kuchinja unogamuchirwa neDFA, uye mashoko akanaka ndeokuti mune zvakawanda mune pipeline. Izvo zvinotaurwa, iyi mishonga inogona kana kuti ingasava yakakunakira iwe.
Pane zvakawanda zvaunofanira kufunga paunosarudza mushonga weSMS semamwe mararamiro ako, kana iwe ungava nepamuviri munguva ichangopfuura, uye zvinogona kukuvhiringidza nemigumisiro yakaipa inosanganiswa nayo.
Uyezve, Zinbryta inogona kunge isina "nani" kupfuura yako yazvino yemesipiritiri yeE-disease-modifying therapy. Pakanga paine chidzidzo chimwe chete ichichienzanisa naVavonex. Nokudaro nepo Zinbryta yakaderedza nhamba yekudzokazve yakaenzaniswa naAvonex, hatigoni kuisa izvi kune mamwe maSrapies.
Sources:
Ndarama R et al. Daclizumab yakakura-kubereka nzira yekudzorerazve-remitting multiple sclerosis (SELECT): chirongwa chisinganzwisisiki, cheviri-blind, testbo-controlled controlled. Lancet. 2013; 381) 9884): 2167-75.
Kapos L et al. Daclizumab HYP uye Interferon Beta-1a Kudzokorora Multiple Sclerosis. N Engl J Med . 2015; 373 (15): 1418-28.
Milo R. Kubudirira uye kuchengeteka kwe daclizumab uye inogona kuita basa mukurapa multiple sclerosis. Ther Adv Neurol Disord. 2014; 7 (1): 7-21.
US Food and Drug Administration Kunyora Mashoko. (2016). Zinbryta.