Kuongororwa kweRopa kunotsvaga njodzi yehutano hwehupombwe hweSMS
Progressive multifocal leukoencephalopathy (PML) chirwere chisingawaniki chepfungwa. Ngozi ye PML dzimwe nguva inowedzera kune vanhu vanotora Tysabri (natalizumab) , chirwere chinoshandiswa nehutachiona chinoshandiswa kudzivisa kudzokerazve kune vanhu vane multiple sclerosis (MS) .
PML inokonzerwa nehutachiona hwaJohn Cunningham (JC virus), hutachiona hwehutachiwana hunowanzochengetedzwa nehutachiona hwehutachiona.
Zvisinei, kana zvirwere zvekudzivirira muviri zvisingakwanisi, hutachiona hunogona kugadzirisa uye hunokonzera kukanganisa kwakakomba uye kunogona kutyisa upenyu hweuropi.
Kuti udzivise izvi mune vanhu vane MS, vanachiremba vachaita kuedza kweanoropi kuti vaongorore humwe hutachiona muropa remunhu.
PML uye JC Virus
Kutsvakurudza kunoratidza kuti vanenge makumi manomwe kubva muzana vevanhu veUnited States vane utachiona hweJC. Vanhu vakawanda havazivi kuti vane utachiona, uye vashomanana vanombosangana nehosha nemhaka yehutachiona.
Izvo chete kana munhu akadzivirira kudzivirirwa kwezvirwere kuti chirwere chacho chinogona kuva "chakanaka." Izvi zvinongoreva kuti muviri hauna nzira yekuzvidzivirira pachayo, uye hutachiona hunoshandisa mukana wokukonzera zvirwere.
Tinoona izvi kune vanhu vane hutachiona hwakakosha . NeHIV, hutachiona hunoendesa hutachiona hutachiona hunoita kuti muviri huve nehutachiona hunopararira (OIs).
PML iri pakati peOIs uye inorondedzerwa semamiriro ekujekesa AIDS mune vanhu vane HIV.
Ne MS, chikonzero chacho chakasiyana zvakasiyana. Muchiitiko ichi, kuvhara muviri kunokonzerwa nemimwe mishonga inoshandiswa kurapa MS. Iyi mishonga inosanganisira Tysabri, Tecfidera (dimethyl fumarate), uye corticosteroids.
Kana imwe yadzokazve, hutachiona hunogona kupfuura nepamuviri wega / uropi hunoparadzanisa hutachiona hwehutano kubva kune imwe yose yomuviri.
Pakupedzisira, chikamu chiduku chevanhu vanotora Tysabri chichaita PML uye chinowedzera kukanganisa avo vane zviitiko zvinotevera:
- Yakare kana kuti ikozvino kune dzimwe zvirwere zvekudzivirira zvirwere (zvakadai se azatioprine, cyclophosphamide, dimethyl fumarate, methotrexate, mitoxantrone, kana mycophenolate mofetil)
- Kushandisa Tysabri kwemakore anopfuura maviri
- Kuongororwa zvakanaka kune JC virus antibody
IJC Virus Antibody Blood Test
Zvirwere zvinorwisa muviri zvinodzivirira zvirwere zvemuviri zvinokonzerwa nemajoni ehurumende pakupindura chirwere chinokonzera chirwere chinonzi JC virus. Munhu wose anoripikisi anonyatsotaura kune iyo pathogen uye iyo pathogen oga. Kana kangoerekana yabudiswa, anti-antibody iyo ichagara mumuviri kuti inopindura muitiko iyo pathogen inodzoka.
Kuti kusimbise hutachiona, tichaita chirongwa cheropa chisinganzwisisiki chakagadzirirwa kuona hutachiona hunokwana. Chigumisiro chemuedzo chingatiudza chimwe chezvinhu zviviri:
- Chiitiko chakanaka chinoreva kuti munhu ave akaratidzirwa nehutachiona.
- Mhedzisiro isina kunaka inoreva kuti hakuna humwe uchapupu hwekutsvaga.
Dambudziko iri, hongu, ndeyekuti vazhinji vevanhu vachave vaine utachiona neJC virus.
Saka kunyange zvazvo chiitiko chakanaka chingaratidza kuwedzera kwengozi yePPL, haisi kupesana nekurapa. Pane kudaro, inobvumira chiremba kuti atarise izvi uye zvimwe zvinokonzera njodzi kuti asarudze kana Tysabri yakakodzera kana kana dzimwe nzira dzakanaka dziripo.
Panguva imwecheteyo, kuedza kweanoripisi hakuna kukwana, uye kune matatu muzana yeruzivo kuti inogona kutora mhinduro-nhema. Ichi ndicho chimwe chezvikonzero nei kuedza kwechirwere ichi kuchiitwa vasati vatanga Tysabri uye vanodzokorora mwedzi mitanhatu gare gare kuti vaongorore chero basa revirusi.
Shoko Rinobva
Kunyange zvazvo JC virus antibody test inobatsira pakusarudza kuti ndiani angave ari pangozi yekuvandudza PML paanoshandisa Tysabri, haifanire kuderedza kukosha kwemishonga mukudzivirira kweSMS zvakare.
Pakupedzisira, chisarudzo chekushandisa Tysabri kana kwete chiri munhu mumwechete uye chinofanira kuitwa mukukurukurirana nechiremba wezvenyanzvi. Kana kurapwa kuchirongwa, nguva dzose kuteverwa kwakakosha kuti usangotarisa kubudirira kwehutano asi kurega chero zvinogona kuitika.
> Sources
> Gorelik, L .; Lerner, M .; Bixler, S. et al. "Anti-JC virus antibodies: zvinokonzerwa nekambani yePML yokucheka ngozi." Annals of Neurology. 2010; 68 (3): 295-303.
> Schwab, N .; Schneider-Hohendorf, T .; Pignolet, B. et al. "Kurapa ne natalizumab kunobatanidza nepamusoro JC seroconversion uye kuwedzera kweJCV nhamba yehutano." Neurology: Neuroimmunology & Neuroinflammation. 2016; 3 (1): e195.