Zvinyorwa pamusoro pezvikonzero zveCFS
Chii chinokonzera kusingaperi kuneta kwechirwere? Mubvunzo wakaoma! Pasinei nekutsvakurudza kwakawanda, nyanzvi dzisina kukwanisa kuzvipinza pane chero chikonzero chimwe chete. Vamwe vanodavira kusagadzikana kuneta ( syndrome) ( ME / CFS ) kunogona kuitika kubva pane zvinhu zvakawanda zvinouya pamwechete pasi pemamiriro ezvinhu akanaka. Izvi zvinogona kusanganisira:
- Genetic factors
- Central nervous system (CNS) uye humoni husina kunaka
- Chirwere kana humwe hutachiona
- Immune system isingaenzaniswi
- Kunetseka
- Kuisa pachena kune chepfu
Haasi munhu wose ane ME / CFS ane zvinhu zvose izvi zvinoitika. Vangangodaro vane kusanganiswa kwevo, kwechimwe chikonzero, kwakatungamirira kumamiriro acho. Nokuti kusanganiswa kwakasiyana kwezvinhu kunogona kukonzera zviratidzo zvakasiyana uye kuchinja mumuviri, nyanzvi dzinoratidza zvikamu kana masangano e ME / CFS. Pakupedzisira, boka guru rinogona kukubatsira iwe uye chiremba wako kuverenga nzira yakanakisisa yekukubata nayo.
Genetic Factors
Kutsvakurudza kunobatanidza ME / CFS nemajene akabatanidzwa munyaya ye hypothalamic-pituitary-adrenal (HPA) axis uye hurongwa hwekunzwa tsitsi. HPA axis inodzora kurara kwako, kupindura kudzvinyirira, uye kuora mwoyo.
Mukuongorora kwakaitwa muna 2006 muna Pharmacogenetics , vatsvakurudzi vakatarisa DNA iyo inodzora kuti muviri wako unogunun'una sei nekushungurudzika, kukuvara uye kushungurudzika, uye vakawana kuchinja kwakafanana kunogona kufanotaura ME / CFS ne 76 muzana yakarurama.
ICDC inonzi iyi "humwe uchapupu hwechokwadi hwehupenyu hwehutano husingaperi hwehutano." Kunyange zvakadaro, vatsvakurudzi vakanga vasingakwanisi kuongorora mazita ezvemajini kana kuti kuona kuti kuchinja kwakaita sei zviratidzo.
Zvimwe zvidzidzo zvinoratidzira maitiro ekusaremara kwevanhu vane ME / CFS iyo inokonzera maitiro ekudzivirira muviri, mafoni ekukurukurirana, uye nzira dzinoita masero ako kuwana simba.
Zvose izvi zvinoratidza kuti vamwe vanhu vangave vaine mazita akasiyana-siyana kune ME / CFS - mune mamwe mazwi, vanogona kuitora kana zvinokonzera zvakakwana zvichiuya pamwechete. Semuenzaniso, kana mumwe munhu akachengetedzeka ari kutarisana nenguva inonetsa uye anobva atarirwa kune rimwe chirwere kana chepfu, vachakudziridza ME / CFS. Mumwe munhu ane mahedheni akasiyana-siyana, zvisinei, aizouya nemamiriro ezvinhu akafanana uye ave akanaka.
CNS & Hormones
Sezvambotaurwa pamusoro apa, vamwe vanhu vane ME / CFS vane zvisiri izvo muHPA axis. Vatsvakurudzi vanonyanya kufarira mune zvimwe zvepakati-nervous-system makemikari nemahomoni anotungamirirwa neHPA axis:
- Neurotransmitter inoshanduka
Neurotransmitters makemikari anotaura mashoko muuropi yako. Kutsvakurudza kwakaratidza kuti vamwe vanhu vane ME / CFS vane maitiro asina kukodzera emamwe mativi eurotransmitter anokosha ( serotonin uye dopamine ). Vatsvakurudzi vari kushanda kuti vatsanangure basa iro kusakanganiswa kuridza mu ME / CFS. - Kushungurudzika hormone kukanganisa
Nyanzvi dzinoziva mazinga ekudzvinyirira hormone cortisol dzakaderera mukati meMe / CFS varwere, uye vanofunga kuti izvi zvinogona kuita kuti zvive zvakaoma kubata nematambudziko - kana mumuviri (zvakadai sehutachiwana kana kuedza) kana mupfungwa. Kortisol kudzokera kunobatsira vamwe, asi kwete vose, ME / CFS varwere. Mune chidzidzo che2008, vakadzi vane ME / CFS vaiva nechepamusoro-soro ye-cortisol panguva apo varume vane ME / CFS vasina, izvo zvingabatsira kutsanangura kuti sei mamiriro acho akawandisa kune vakadzi.
- Zvinotambudza circadian rhythms
Your circadian clock (chikamu cheHPA axis) inoronga kurara kwako. Uchapupu hunoratidza kuti mune vamwe vanhu vane ME / CFS awa ino inodzingwa, zvichida nechakaitika mupfungwa kana mumuviri, uye muviri haugone kuwana rwiyo rwakakodzera zvakarezve. Vanhu vane dambudziko iri vanoita sevanopedza nguva yakawanda musangano rekurumidza-yeziso (REM) chikamu chehope, iyo apo iwe uri kurota. Vanhu vari muchikamu chino che ME / CFS vanowana rubatsiro rwezvemishonga yekurara kupfuura vanhu mune mamwe masangano, maererano nenyanzvi.
Zvirwere
Zvizhinji zvezviratidzo nezviratidzo zve ME / CFS zvakafanana neyechirwere chetachiona chinoramba chichiwedzera, saka tsvakurudzo yakawanda yakaratidza kuvepo kwechirwere chetachiona kana chinotapukira.
Vatsvakurudzi vakaongorora nhatu dzedzidziso dzine hutachiona, zvisinei kuti hapana chakaonekwa:
- Utachiona kana bhakitiriya inokanganisa muviri uye inokuvadza masimba ezvirwere. Dambudziko racho rinoenderera mberi richikonzera zvirwere-zvirwere zvakadai kunyange mushure mokunge utachiona kana mabhakitiriya apera.
- Mushure mechirwere, chiito chisina kujairika nehutachiona hwemumusimba chinokonzera hutachiona hwakanga husina kushanda kuti hugadzirise zvakare.
- Mhinduro yehupenyu kune hutachiona hwehutachiona hunoitika kune vanhu vanotambura.
Kunyange zvazvo isiri munhu wose ane ME / CFS inoratidza zviratidzo zvehutachiona, vazhinji vanoita. Zvikamu zvitsva zvehupowo zvinotsigira pfungwa yokuti vamwe ME / CFS inokonzerwa nechepakati muchikamu nehutachiwana:
- Enterovirus connection
Mune chidzidzo che2007, vanhu vane ME / CFS vaipetwa kanomwe kupfuura vanhu vane hutano kuti vave nehumwe hutachivirusi mumatumbu. Inoviruses inokonzera zvirwere zvemudumbu, uye zviratidzo zve ME / CFS zvinowanzotanga mushure mekurwara kwakadaro. - Rnase L
Mumuviri wako unoshandisa enzyme Rnase L kuuraya mavairasi ari kurwisa masero ako, uye varwere veMe / CFS vanowanzova nepamusoro peRnase L basa. - Natural Killer (NK) Makero uye T Tema
Nhengo dzemuN & T mumasimba ako ezvirwere zvinokonzera masero ane utachiona hwehutachiona, uye vanhu vane ME / CFS vanowanzoora mwoyo NK uye T masero mabasa uye nhamba, zvichiratidza kuti chirwere chisingaperi chekudzivirirwa mumuviri chinogona kuva chinopisa uye chichivhiringidza. - Antibodies
Vanhu vane ME / CFS vanowanzova nehuwandu hwezvirwere zvinopesana nehutachiona hunokonzera utachiona hunokonzera kuneta uye zvimwe zviratidzo zveM ME / CFS. Izvi zvinosanganisira izvo zvinokonzera candida (mbiriso), human herpesvirus type 6 (HHV-6), masero, parvovirus, uye Epstein-Barr . Vanotsvakurudza havana kukwanisa kuratidza kuti chimwe cheizvi ndicho chikonzero chikuru che ME / CFS. - Post-chirwere chinotanga
Kusvikira ku80 muzana ye ME / CFS mhosva dzinotanga pakarepo mushure mekuda kwemamiriro ekurwara. - Cluster breakbreaks
Kunyange zvazvo CDC isina kusimbisa zvikamu zvakawanda zvemasumbu, mapepa evanhu vakawanda mumhuri imwe chete, nzvimbo yebasa, uye munharaunda inosimudzira ME / CFS panguva imwe chete haisi kunzwa.
Vamwe vatsvakurudzi vanoratidza kuti kuchinja kunowanzoshaya bhakitiriya inokuvadza mumatumbo kunogona kuita basa mukusimudzirwa kwe ME / CFS.
Zvisinei, humwe humwe uchapupu hunoita sehwunopesana nehutachiona-hunokonzera dzidziso. ME / CFS haina kuonekwa kupararira kuburikidza nehuwandu hwehuwandu, vanhu vane nayo havaoneki vane hutachiwana, uye-pasinei nekuongorora kwakagadzirwa zvakanaka - vatsvakurudzi havana kukwanisa kubatanidza ME / CFS nezvimwe zvirwere zvakasiyana.
Tsananguro Nezve XMRV
Muna 2009, vatsvakurudzi vanobva ku Whittemore Peterson Institute (WPI) vakabudisa chidzidzo mumagazini yeSayenzi vakaratidza kuwirirana pakati pe XMRV, retrovirus yakangobva kuwanikwa, uye ME / CFS. Vakawana XMRV munenge 67 kubva muzana yeropa samples kubva kuvarwere veM ME / CFS. Vakatorawo izvi mu3% yehutano hwakanaka.
Zvisinei, zvidzidzo zvinotevera zvakakundikana kusimbisa hukama, kusanganisira chidzidzo chikuru chinosanganisira WPI nyanzvi yekutsvakurudza. Zvimwe zvidzidzo zvakaratidza nzira iyo kusvibiswa kungave kwakagadzira zviratidzo zvenhema mune zvidzidzo zvepakutanga. Pakazosvika gore ra2011, rondedzero ye XMRV yakanga isiri-asi yakasiyiwa.
Immune System
Tsvakurudzo dzinoverengeka dzakaratidza kusava nehutachiona muhutachiona hwevanhu vane ME / CFS, asi vatsvakurudzi havana kuwana nzira isingaenzaniswi yekusagadzikana. Pakati pezvinowanikwa zvakanyanya ndezvipi zvoutachiona uye zvinopfurikidza zvekudzivirira muviri.
Zvimwe zvidzidzo zvakashuma kuti vazhinji veMES / CFS varwere vanongoratidzira kune zvinhu zvinosanganisira mapureni, zvokudya uye zvigadzirwa zvakadai sa nickel uye mercury.
Izvo zvinotungamirirwa kunyanzvi yokuti zvipembenene zvinogona kukonzera kukanganisa kwezvidziviriro zvemuviri zvinotungamirira kuM ME / CFS. Imwe nyanzvi ndeyekuti kuora mwoyo, kushungurudzika uye utachiona zvinogona kubatanidza kupedza chemikirini inonzi adenosine triphosphate (ATP), inochengeta simba mumasero. Vamwe varwere veM ME / CFS vanoratidza uchapupu hwekuderera kweAtP.
Vamwe veMe / CFS varwere vane huwandu hwakawanda hwezvinhu zvinonzi cytokines , izvo masayendisiti anonzi aorize angaita zviratidzo zve ME / CFS, kusanganisira kuneta uye muscle aches. Zvidzidzo zvakasiyana-siyana zvakashuma T kusabatanidzwa kwemasero kune vanhu vane ME / CFS, asi zvimwe zvidzidzo hazvina kusimbisa T cell uye cytokine zvisiri izvo.
Kurwara kuneta kwenguva refu kunoratidzika kuva nezvinhu zvishoma zvakafanana nezvirwere zvinokonzerwa ne autoimmune zvakadai se lupus kana multiple sclerosis , iyo maitiro emusununguko anorwisa zvisina kunaka nhengo dzomuviri. Chimwe chikwata chinokura chekutsvakurudza chinoratidza kuti ME / CFS inogona kuva autoimmune.
Kushungurudzika
Vatsvakurudzi vanotenda maitiro ako epfungwa, unhu uye hukama hwemagariro zvinogona kuita kana iwe uchizokwidziridza ME / CFS, asi ivo vasati vava kunyatsonzwisisa hukama hwakaoma pakati pavo.
Kunyange zvazvo zvinhu izvi zvichida kwete chikonzero chikuru che ME / CFS, ivo vanogona kuita basa mukuita kuti iwe uonekwe.
Cherechedza: ME / CFS haifaniri kufunga kuti chirwere chepfungwa chikuru, uye kusava neMES / CFS kunoreva mumwe munhu ane pfungwa dzepfungwa kana asingakwanisi kurarama nezvinhu. Kunyange zvazvo dzimwe nguva ichibatanidza kuchipatara kudengenyeka, ME / CFS inzvimbo yakasiyana.
Makemikari / Toxin
Mune rimwe boka, kukanganisa kusingaperi uye kurwadziwa zvinosanganiswa nekutsvaga kumakemikari akasiyana-siyana uye zvinokonzera mhuka. Izvi zvinogona kusanganisira zvinokonzera, zvinouraya mishonga kana zvinorema. Zvisinei, nokuti vazhinji vedu takave takarongerwa kune marudzi aya emakemikisi pane imwe nguva, zvakaoma kutarisa pasi izvo zvingave zvichikonzera matambudziko. Chimwe chinonzi multiple chemical sensitivity (MCS) chinokonzera zviratidzo zvakawanda zvakafanana neE ME / CFS, uye iyo mbiri inofungidzirwa kuti inopesana nemamiriro ezvinhu .
Sources:
2006 Centers for Disease Control and Prevention. "Zvinogona Kukonzera"
Dr. JKS Chia. Copyright 2005 Co-Cure. Kodzero dzose dzakachengetedzwa. "Basa re enterovirus muzvirwere zvinopera simba"
Kaiser J. Science. 2011 Jan 7; 331 (6013): 17. Chronic tired fatigue syndrome. Zvidzidzo zvinoratidza kuti zvinogona kusvibiswa mune zvitsva zve XMRV.
Lombardi VC, et al. Sayenzi. 2009 Oct 23; 326 (5952): 585-9. Kuzivikanwa kwehutachiona hwetrovirus, XMRV, muropa revanhu vane chirwere chisingaperi chine simba
Nater UM, et al. Nyaya yemakiriniki endocrinology uye metabolism. 2008 Mar; 93 (3): 703-9. Yakagadzirirwa mangwanani salivary cortisol kuverengera muhuwandu hwevanhu vanogara vane chirwere chisingaperi chine simba uye zvirwere zvakanaka.
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Vernon, S. Pharmacogenomics, Kubvumbi 2006; vol 7: pp. 345-354. Dambudziko rekubatanidza zvakasiyana-siyana data-content data: epidemiological, kliniki uye laboratori data yakabatwa panguva yekudzidza-muchipatara chekusingaperi kuneta kwechirwere.