Frontotemporal dementia (FTD) chirwere chekuora mwoyo chinowanzonzi chirwere chePikk. Inosanganisira boka rematambudziko anokanganisa maitiro, manzwiro, kukurukurirana uye cognition . Mamwe mazita anoshandiswa kuFTD anosanganisira:
- frontotemporal degeneration
- frontal temporal dementia
- Pick yakaoma
- frontotemporal lobar kuderera
Mune FTD, ruzivo rwakatarisa uye rwemakore rweuropi hunovhiringidzwa uye atrophy (shrink) muhukuru.
FTD inowanzorwisa vaduku (50s kusvika makumi matanhatu), asi yakave yakatarwa kune vanhu vaduku se21 uye yekare seyakasvika makore makumi masere. Inenge 60% yezviitiko zveFTD vanhu vari pakati pemakore makumi mashanu nemashanu.
Arnold Pick anotanga kuona kuti maitiro emhando yepurotini yakasvibirira muhuropi (inonzi miviri ya Pick) muna 1892. Miti ya Pick iripo mune mamwe marudzi eFTD uye inogona kuonekwa chete pasi pema microscope panguva yekudzivirira.
Mhando dzeFTD
Zvinetso zvina zvinowira muFTD zvinosanganisira:
- Maitiro Akasiyana-siyana Frontotemporal Dementia
Sezvinorehwa nezita, maitiro akasiyana-siyana eFTD anonyanya kukanganisa maitiro, zvichikonzera kushamwaridzana kusina kukodzera uye manzwiro . - Primary Progressive Aphasia
Chinhu chikuru chechikamu ichi cheFTD ndiAsiasia , iyo inoreva kukanganisa mumutauro unokwanisa. Izvi zvinogona kukanganisa zvose zviri zviviri kukwanisa kutaura uye kunzwisisa. - Progressive Supranuclear Palsy
Supranuclear palsy inokonzera kuenzanisa uye kufamba, pamwe nekugona kugona kunzwisisa. Chiratidzo chakasiyana hachisi kufamba kwemaziso.
- Corticobasal Degeneration
Zviratidzo zvehutachiona hwechirticobasal zvinowanzoonekwa semasimba asina simba uye kudengenyeka, uye kazhinji kunotanga kune rumwe rutivi rwemuviri. Zvinetso nemusoro uye mufambiro zvinowedzerawo sezvo chirwere ichi chinobudirira.
Zviratidzo zveFTD
Vanhu vane FTD vanowanzoratidza tsika dzisina kunaka, dzakadai semashoko asina njere, kusaziva kana kunzwira urombo, kusavhiringidza, kuwedzerwa kufarira kune zvepabonde, kana kuchinja kukuru mune zvido zvekudya.
Vamwe vanoratidza kuchena kwakachena, kudzokorora mazwi kana maitiro, simba rakashata uye kusava nehanya. Vanogonawo kunge vane gwapa kana kuti kusvibiswa , zvichireva kuti zviso zvavo zvinoratidza zvishoma kana kuti kwete kuratidza manzwiro, kusanganisira kusuruvara, mufaro, kana kutsamwa.
FTD inowanzokonzera kukwanisa kukurukura mutauro wemashoko ose (kukwanisa kushandisa mazwi kuzviratidza) uye kutaura kunonzwa (kukwanisa kunzwisisa mutauro). Vanhu vangave vaine dambudziko kuwana izwi rakarurama rokuti vataure, vataure chaizvo vasingatyi uye zvishoma nezvishoma, vane nguva yakaoma yekuverenga nekunyora zvakarurama, uye vasingakwanisi kugadzira mitsara nenzira inonzwisisika.
Movement Changes
FTD inowanzokonzera kukwanisa kudzora kufamba uye zvimwe zviito zvemotokari. Vaya vane FTD vanogona kuwira kazhinji kana kuti vasina ruoko rusingadikanwi uye netsoka dzemakumbo kana shakiness.
Zvinofadza, kuti munhu anoyeuka uye anonzwisisa nzvimbo yakavapoteredza kazhinji inoramba yakanyanyisa, kunyanya mumatanho ekutanga.
FTD neAlzheimer Vari Kusiyana Sei?
MuAlzheimer, inowanzo zviratidzo zviratidzo zvenguva pfupi yekuyeuka uye kuoma kudzidza chimwe chinhu chitsva. Mune FTD, chiyeuchidzo chinowanzogadzikana pakutanga; Zviratidzo zvepakutanga zvinosanganisira kuoma nekubatana kwakanaka kwevanhu uye manzwiro, uyewo mamwe matambudziko emutauro.
FTD neAlzheimer yakasiyanawo nenzira iyo uropi hune hutano hunoitika. FTD inonyanya kukanganisa uropi hwomukati uye hwemakore masikati; asi apo Alzheimer inotanga kuchinja nzvimbo dzakawanda dzeuropi.
FTD inoshorawo vanhu vaduku. Ivhareji yemakore ekutanga kweFTD inenge makore makumi matanhatu. Kunyange zvazvo vamwe vanhu vane kutanga kweAlzheimer's, vazhinji vevarwere vanopfuura makumi mashanu nemashanu uye vazhinji vevaya vari mumakore makumi manomwe kana makumi matanhatu.
Chii Chinokonzera FTD?
Chikonzero cheFTD hachizivikanwi. Nepo huwandu hwematambudziko eFTD hunoita sekukudziridza nechiitiko, genetics inobatsira pane dzimwe nguva. Inenge 10% yematambudziko inogona kuteverwa kumashure kune kuchinja mune rimwe gene.
Izvi zvinokonzerwa nejenisi zvakatorwa zvakananga, zvinoreva kuti kana mai vako kana baba vane geni yakadaro yeFTD, une mukana we50% wekuvandudza FTD.
Anowedzera 20% kusvika ku40% yevanhu vanoona kuti vane FTD vane ukama hwemhuri umo kune imwe nhengo imwechete kupfuura zvizvarwa zviviri kana kupfuura zvakawanikwa kuti ine FTD.
Kuziva
Kufanana nekuongororwa nechirwere cheAlzheimer , hapana dambudziko rimwe chete rinogona kuongorora FTD. Varwere vanowanzofungidzira kuedza kwakadai seMRI kana PET scan ; kuongororwa kunzwisisika kuyera chiyemi uye mutauro mano; physical movement testing; zvichida mushonga wepuropa ; uye dzimwe kuongororwa ropa. Kuongororwa kunoitwa nokuunganidza zvose zvinoguma kubva kune izvi kuongororwa, kutonga zvimwe zvikonzero zvakadai sehutachiwana B12 kana kuti hutachiona, nekuenzanisa zviratidzo zvako kune dzimwe mamiriro eFTD. Zvakakosha kuti nyanzvi yezvehutano inozivikanwa neFTD nemamwe marudzi ehutano hwemangwana inobatanidzwa mukuongororwa uku sezvo zvimwe zvikamu zveFTD zvinomesa zvimwe zvinetso.
Mishonga
Hapana mishonga inokonzera rudzi urwu rwekushaya mungozo, saka chinangwa chekurapa ndechekudzivirira zviratidzo zvakanyanya. Vanachiremba vanogona kupa mishonga inowanzoshandiswa pakutambudzika kwekufamba muPalinson's disease , kusanganisira Carbidopa / levodopa (Sinemet) . Dzimwe nguva mafambiro eFTD anotaridzwa nemishonga inorwisa antipychotic kana kusina madhiragi kuswedera kusina kubudirira.
Kurapa zvinodhaka, kunyanya kusarura serotonin reuptake inhibitors (SSRIs), zvakaratidza kubatsirwa kumwe mukurapa zvimwe zvekudzivirira kana kusagadzikana maitiro eFTD. Vamwe vanachiremba vachapawo mishonga inowanzopiwa varwere veAlzheimer, kusanganisira cholinesterase inhibitors . Tsvakurudzo, zvisinei, haina kuratidza zvakajeka mishonga iyi kuti ibudirire kune FTD zvakadaro.
Kurapa kwepabonde uye kwepanyama kunogona kubatsirawo varwere nekubatsira kuchengetedza kana kuderedza kuora kwemotokari uye simba rekufambisa, nepo chirongwa chekutaura dzimwe nguva chinogona kubatsira pakukanganisa kukurukurirana.
Kuwanda kwePetotemporal Dementia
Inenge 10 kusvika ku20 muzana yevanhu vose vane dementias ndeye FTD, iyo inoshandura kune inofungidzirwa 50,000 kusvika ku 60,000 vokuAmerica. FTD ndeimwe yenhengo dzakawanda dzinowanzosangana nehutano hwemangwana mukati mevanhu vakuru vari pasi pemakore makumi matanhatu nemashanu, uye zvinowanzoonekwa kune varume kupfuura vakadzi.
Prognosis
Kufananidzira kweFTD kwakaipa. Tarisiro yehupenyu yakasiyana kubva kune makore maviri kusvika kumakumi maviri mushure mekuongororwa, zvichienderana nekukurumidza kwekuwedzera uye kuvapo kweimwe zvirwere. FTD haina kukonzera rufu, asi inokonzera kurwisana nedzimwe zvirwere uye zvirwere zvakaoma.
> Sources:
> Association for Frontotemporal Degeneration. Kuziva.
> Association for Frontotemporal Degeneration. Frontotemporal Degeneration.
> Association for Frontotemporal Degeneration. Genetics.
> Association for Frontotemporal Degeneration. Chii chinonzi FTD?
> National Center for Biotechnology Information, US National Library of Medicine. Pub Med Health Utano. Pick's Disease.
> University of California, San Francisco. Mafomu eDementia Frontotemporal.
> University of California, San Francisco. Hereditary FTD.
> US National Institutes of Health. National Institute on Aging. Mitauro yePreotemporal Disorders.