Zvirwere zvePacinsinson

Chirongwa chezvirwere zvePasinson

Chirwere chePacinsinson chinowanzovapo nekuda kwekufa kwei-dopamine-inobudisa masero emasero muuropi. Dopamine inonzi neurotransmitter inokosha (kemikari inopinda muuropi) iyo inobatsira kudzora misi miitiro. Saka apo dopamine yakapera muuropi, zviratidzo zvakadai sokuzununguka, kuoma, uye kufamba zvinetso zvinoitika.

> Dopamine-inobudisa masero muuropi anenge apera muhosha yaPasinson.

Kunyange zvazvo chirwere cheParkinson chinoshandiswa kuonekwa sechikonzero chekufamba (motokari) chirwere, nyanzvi zvino vanoziva kuti zvinokonzera zviratidzo zvisiri zvemumikirwo zvakadai sematambudziko ekurara, kuvimbiswa, nekurasikirwa kwekunhuwa.

Chinofadza ndechekuti zviratidzo izvi zvinogona kutanga kutora zviratidzo zvemotokari nemakore mazhinji, kunyange makumi emakore.

Zvakakosha kunzwisisa kuti chirwere chePasinson chirwere chakaoma. Asi nekudzidza zviduku zvezivo nezvehutano hwehuropi, iwe watova munzira yako yekurarama zvakanaka (kana kubatsira mumwe waunoda) kurarama zvakanaka nazvo.

Chikonzero cheMapirini aPasinson

Kunyange zvazvo chikonzero chaicho chechirwere chePasinson chinowanzozivikanwa, nyanzvi dzinofunga kuti zvinokonzerwa nekubatana kwakakomba pakati pemararamiro ako nemamiriro ake ezvinhu.

• Parkinson Inokanganisa Upenyu Husingatarisiri Here?

• Nzira Yokukunda Kusangana Masikati muPalinson's Disease

Mienzaniso yekusununguka kwezvakatipoteredza izvo zvinogona kukonzera kukura kwechirwere chePasinson mumunhu anokonzerwa nehutachiona zvinouraya mishonga kana mararamiro. Zvimwe zvinokonzerwa nehutachiona hwePestinson zvirwere zvinowedzera makore uye hutano (chirwere chePasinson chinowanzoonekwa kuvanhu).

Zviratidzo zvezvirwere zvePasinson

Zviratidzo zvehosha yaPasinson zvinogona kuva zvisinganzwisisiki kare-muchokwadi, vangave vaenda vasingaoneki. Asi pakupedzisira zviratidzo zvishoma nezvishoma zvinowedzera nenguva.

Inodhura Zviratidzo muMurwere waPasinson

Zvikamu zvina zvinoratidzira motokari zviratidzo zvePalinson's disease ndezvi:

• Kupopota
• Bradykinesia (slowly movement)
• Rigidity
• Postural kusagadzikana (pfungwa yekusaenzana)

Kupopota mune chirwere chePasinson chinonzi "pill-rolling" kudengenyeka nemhaka yezvazvinoratidzika-sekunge munhu ari kuvhara mapiritsi kana chimwe chinhu chiduku pakati pechigunwe chake uye index finger. Inotsanangurwawo sekuzununguka kwekuzorora nokuti zvinoitika apo chikamu chemuviri (sakaita ruoko) chakasununguka uye chizorora. Kana munhu achiita kufamba kwechinangwa, sekusvika kwegirazi, kudengenyeka kunoderera kana kuparara. Kuvhunduka kunogona kuwanikwa mune dzimwe nhengo dzomuviriwo, segumbo kana rushaya, uye kazhinji zvinowedzera kuora mwoyo nekudzvinyirira.

Zvinonakidza kuziva kuti kana kuvhara kudengenyeka kunowanikwa muhuwandu hwevaya vane chirwere chePasinson, hachisipo kune vose.

Bradykinesia inotsanangura kukanganisa kwemunhu kuderera. Sezvaunogona kufungidzira, izvi zvinogona kunyanya kudzivisa. Munhu angafambira mberi kubva mukuoma achishandisa minwe yake (somuenzaniso, kuzarura chirongo kana kuisa) kuoma kushandiswa nemakumbo avo, zvichiita kuti pave nechisimba chekuita nemaitiro mashoma.

Kusimba kunoreva musimba uchishushikana uye kurwisana nemisungo yekuzorodza. Munhu ane rusununguko angave asina kutambanudza maoko ake zvikuru kana achifamba, kana iye angave achida kuchinja kana kupfugama mberi.

Kubata kunogona kuva kunorwadza, uye izvi zvinogonawo kuita kuti pave nekutambudzika kufamba, kunyanya kufamba.

Chimwe chiratidzo chePalinson's disease ndechekusava nekugadzikana kwepfungwa-pfungwa yekusawirirana kana akamira. Ichi chiratidzo chinowanzomuka gare gare munguva yezvirwere zvePasinson. Mune munhu ane mushure mekusava nekunyengedzera, kamukira kadiki paruoko kunogona kutungamirira kuti vawire.

Kune dzimwe dzakawanda zviratidzo zvine chokuita nemotokari muPalinson's disease, uye kuvapo kwavo kune kushanduka, zvinoreva kuti havasi vose vanoona zviratidzo zvakafanana kana kuti vane dhigirii imwechete. Zvimwe zvezviratidzo izvi zvine chokuita nemagetsi dzinosanganisira:

• Ziso rakaderera rinopenya
• Kutapudza chiso chekutaura
• Kutaura uye kumedza matambudziko
• Kuwedzerwa kwematope ekugadzirwa
• Kusunungura mapepa -apo munhu anonzwa sokuti tsoka dzavo dzakasimudzirwa pasi kana pasi rezvo rakanyongedzwa kusvika pachigaro

Kwete-Zviratidzo muMurwere wePasinson

Sezvo kutsvakurudza nezvechirwere cheParkinson kuchifambira mberi, nyanzvi dziri kutarisa zvakanyanya uye zvakanyanya pane zviratidzo zvisingaiti motokari. Zviratidzo izvi zvinowedzera kuora mwoyo kune munhu kupfuura motokari dzavo zviratidzo, uye vanogona kutanga makore apfuura.

Mienzaniso yezvirwere zvisiri-motokari muhosha yaPasinson inosanganisira:

• Hluccinations (kazhinji kuonekwa) uye / kana kukanganisa
• Matambudziko emafungiro akaita sekuora mwoyo, kuzvidya mwoyo, uye kusava nehanya (kurasikirwa kwechido uye manzwiro)
• Matambudziko okurara uye kuneta kwezuva
• Matambudziko ehupfungwa uye kuora mwoyo
• Autonomic dysfunction (somuenzaniso, kudonha kweropa remuviri kana ukamira kana kuvimbiswa)
• Kushungurudzika kwepfungwa sezvinopera uye kushungurudza kana kurwadziwa
• Zvinetso zveganda (somuenzaniso, seborrheic dermatitis)
• Kurasikirwa kwekunzwa kunhuwa

Kuongororwa kwezvirwere zvePasinson

Kuonekwa kwechirwere chePasinson kunoda kuongorora uye kunyatsorongororwa nachiremba, kazhinji nyanzvi yezveuropi , sezvo pasina slam dunk yeropa romuedzo kana uropi imaging test for it. Kunyange zvazvo kuongororwa kwakajeka kune vamwe vanhu, zvinogona kunge zvakaoma kune vamwe, kunyanya sezvo pane zvimwe zvishomanana zvimwe zvirwere zvehutano izvo zvinogovana zviratidzo zvakafanana nechirwere chePalinson.

Kana chiremba wako achifungira chirwere chePasinson, achabvunza mibvunzo yakawanda pamusoro pokurara, mafungiro, kurangarira, kufamba matambudziko, uye kuwira kwezvino.

• Vana Vangu Vanogona Kuwana Dambudziko raPalinson Kubva Kwandiri Here?

• Mhedzisiro uye Kurapa kweKubata muPalestin's Disease

Achaitawo kuongorora kwepanyama kuti aongorore mafungiro, simba remuviri, uye kuenzanisa. Usashamiswa kana kufungidzira kuongorora kana kuongorora ropa kunorayirwa kutonga kunze kwehumwe hutano.

Panewo zvimwe zvirevo zvinotevera chiremba anotevera kutevera chirwere chePalinson. Semuenzaniso, imwe tsanangudzo inotsigira chirwere chePalinson's chirwere ndechokuti kana munhu ane zviratidzo zveParkinson ane zviratidzo zvakajeka muzviratidzo zvavo mushure mekutora levodopa (mushonga unoshandiswa mukurapa chirwere chePasinson).

Kunyange zvazvo pasina mushonga wePalinson's disease, mashoko akanaka ndeokuti kune nzira dzakasiyana-siyana dzokurapa kuti udzivise zviratidzo kuitira kuti iwe kana mudiwa wako urarame zvakanaka naro.

Kuchengetedzwa kweMigodhi

Kusarudza nguva kuti utange mishonga yemamoto zviratidzo haisi nguva yakanatswa-kana zvichibva kune munhu uye kuti zvinoderedza sei zviratidzo zvavo. Ichokwadi, unogona kushamisika kuziva kuti mumatangiro epakutanga kwePalinson, chirwere chingasadikanwa.

Carbidopa-levodopa, iyo inofamba nemazita ezita rinonzi Sinemet kana Parcopa, ndiyo inonyanya uye inoshanda zvikuru yeMishonga yaPasinson. Levodopa inoshandurwa kuva dopamine muuropi, iyo inobatsira kudzorera musimba kudzora. Carbidopa inoita kuti levodopa ibudirire kuburikidza nokuidzivisa kuti isashandurwe kuva dopamine kunze kweuropi.

Izvo zvakaderera zveizvi zvimwe zvinoshanda zvakanyanya mishonga ndeyokuti kana munhu aive aripo kwemakore, zvingasava zvakanaka pakugadzirisa zviratidzo zvemotokari-izvi zvinonzi "kuvhara" mhizha. Mukuwedzera, kufamba kwakasununguka kwako kufanana nemasaisai emasumbu kana kuputika (kunonzi dyskinesia) kunogona kuitika mushure mekushandisa kwenguva refu yevodopa.

Dopamine agonist like Mirapex (pramipexole) uye Requip (ropinirole) inokurudzira dopamine-receptors-docking sites-muuropi, inonyengera uropi pakufunga kuti ine dopamine inoda kuti muviri uende. Dopamine agonist haisi yakasimba kudarika levodopa, uye vane mhando dzakawanda dzingava nemigumisiro yakadai sekuona maziso, kurwisa kurara (kurara kwakanyanya), uye kuzvibata kwakasimba sekubhejera, kudya, kutenga, kana kuita zvepabonde.

Izvo zvinotaurwa, dopamine agonists dzimwe nguva inoshandiswa mumatanho ekutanga ehosha yaPasinson, achidzokorora kukosha kwevavodopa kusvikira gare gare mune chirwere chechirwere. Izvi zvinogona kubatsira kudzivirira zvinetso zvemazuva mazhinji zveLevodopa se "kuvhara" zvinoitika uye kunze kwekudzora kufamba kwemuviri.

Monamine oxidase inhibitors (MAO-B inhibitors) vanosanganisira Eldepryl, Emsam, uye Zelapar (selegiline) uye Azilect (rasagiline), iyo inobata zviratidzo zvemhepo kuburikidza nekudzivisa enzyme iyo inowanzoita kuti dopamine muuropi iite. Izvi zvinobvumira dopamine inoshanda kuti igare yakakomba muuropi.

Izvo zvinoderedza monamine oxidase inhibitors ndezvokuti hazviiti sevodopa yevanhu vane chirwere chePasinson, uye vanogona kuwirirana nemimwe mishonga, sevanorwisa zvinodhaka.

Izvo zvakakosha ndezvokuti dzimwe nguva vanogona kupa rubatsiro mukudzivisa moto zviratidzo muzvikamu zvekare zvechirwere chePasinson, zvichida kutenga munhu pane imwe nguva asati atanga levodopa.

COMT inhibitors seCtantan (entacapone) uye Tasmar (tolcapone) inowedzera kuburikidza nekuwedzera mhizha yeLevodopa muuropi (saka inotorwa ne levodopa). Iyo inoshandiswa kurapa vanhu vanoona "kupfeka" simba rekuve pa levodopa kwenguva refu. Kuongororwa kwechiropa chekuongororwa ropa kunodiwa kana munhu ari paTarmar (tolcapone).

Anticholinergics yakafanana neArtane (trihexyphenidyl) uye Cogentin (benzotropine) inorayirwa kuti kuderedze kusagadzikana kwekudengenyeka kwevanhu vane chirwere chePasinson. Vanoshanda nekuwedzera acetylcholine muuropi.

Izvo zvinopesana ndezvokuti anticholinergics ine dzakawanda dzinogona kuva nemigumisiro yakaipisisa seyakasviba maziso, yakaoma muromo, kuchengetedza urini, kuvhiringidza, uye kuvhiringidzika (zvikurukuru kune vakwegura). Nemhaka yeizvi, vanochengeterwa avo vane chirwere chePasinson pasi pezera remakore makumi manomwe.

Symmetrel (amantadine) mishonga inorwisa maitiro inoshandiswa muhutano hwepakutanga hwePacinson kuti ishandise kudengenyeka zvishoma uye kusagadzikana. Zvimwe zvinokonzerwa nemigumisiro zvinosanganisira muromo wakaoma, kuvhiringidzika, kuputika kweganda, chikwama chekudzora, kuonekwa kwemaziso, nekuvhiringidzika.

Kurapa kweMusinga-Muchiratidzo

Kunze kwezvinetso zvekufamba zvakasangana nehosha yaPasinson zviratidzo zvinowanzoonekwa zvisingaoneki zvakadai sezvirwere zvekurara, zvinetso zvepfungwa, uye mafungiro ekuchinja, izvo zvingakanganisa hupenyu hwomunhu. Nhau dzakanaka ndezvekuti kune mazano akanaka ekugadzirisa.

Semuenzaniso, kuora mwoyo kwakajairika muhosha yaPasinson, asi inogona kurapwa nemagariro evanhu vanorwara, sezvinoita serotonin reuptake inhibitors. Nokuda kwekutengesa kwepfungwa (kufunga nekuyeuka zvinetso), chiganda cheganda Exelon (rivastigmine) chinogona kunyorwa.

Hluccinations uye psychosis zvinogona kuvhiringidza zvikuru munhu (uye avo vadikanwa) vane chirwere chaPasinson. Kuti atarise izvi, nyanzvi yezveuropiyo inogona kumira kana kuderedza chirwere chemishonga yavo yePasinsinson (somuenzaniso, levodopa). Kune mamwe maitiro akakomba ekufungidzira, mishonga inorwisa antiyythisti inogona kurongerwa.

Mishonga yekuvandudza sekutaura, kushanda, uye kurapa muviri kunowanzoshandiswa kushandura hupenyu hwehutano hwePasinson.

Deep Brain Stimulation

Uropi hwepfungwa hunokurudzira huchengetwa kune avo vane chirwere chePacinson chakakosha iyo motokari zviratidzo hazvibatsirwi kutorwa nemishonga. Inonyanya kubudirira kune vanhu vanoramba vachitsungirira, vachidzivisa kudengenyeka, uye avo vane maitiro asingadzorwiki (anonzi dyskinesia) kana kuchinja ("kukura uye kuoma" zviratidzo), izvo zvinetso zvekushandisa levodopa kwenguva refu.

Uropi hukuru hunomutsa hunosanganisira neurosurgeon kuisa tambo mukati mukati meuropi. Iyi fironi yakabatanidzwa nemutambo unoshandiswa nebheteri unonzi neurostimulator, iyo inowanikwa pasi peganda pedyo necollarbone. Masero emagetsi anokonzerwa neurostimulator (anorongedzwa nemurwere) anotendwa kuchinja nzira dzakakosha dzenzira muuropi dzinodzora kufamba (saka kufamba kwakasununguka kunobudiswa panzvimbo yezvisina kufanana, sekudengenyeka).

Zvakakosha kunzwisisa kuti kurapwa uku hakusi kurapa uye hakugadziri chirwere chePasinson chomunhu kubva mberi. Kunewo njodzi dzakakomba dzakabatanidzwa, kurongedza kukurukurirana kwakanyatsofungisisa nemunhu wezveuropiti, chirwere chechiremba, nemhuri vasati vasangana nayo.

Shoko kubva

Chirwere chePacinsinon chirwere chakakomba chinonzi neurodegenerative ("kufa kwemasero europi") chirwere chisingaiti chete kuti munhu anofamba sei, asiwo maonero avanofunga, kunzwa, kurara, uye kunyange kunhuwa. Kunyange zvazvo zviratidzo izvi zvingave zvisingagoni kubvisa, mashoko akanaka ndeokuti kune nzira dzakakosha dzekudzikisa hupenyu hwavo kana hupenyu hwemudiwa wako.

> Sources:

> Chirwere chaJankovic J. Parkinson: zvipatara zvinowanikwa uye kuongororwa. J Neurol Neurosurg Psychiatry . 2008 Apr; 79 (4): 368-76.

> Parkinson's Disease Foundation. Chii chinonzi Parkinson's Disease?

> Postuma RB. MDS kliniki yekuongorora zvirwere zvePestinson's disease. Endesa Kusagadzikana . 2015 Nha. 30 (12): 1591-601.

> Rao SS, Hofmann LA, Shakil A. Parkinson's Disease: Kuziva uye Kurapa. Ndiye Chiremba weNzara . 2006 Dec 15; 74 (12): 2046-54.

> Wagle Shukla A, Okun MS. Kurapa kurapwa kwechipatara chePasinson: varwere, zvinangwa, zvigadzirwa, uye nzira. Neurotherapeutics. 2014 Jan; 11 (1): 47-59.