Dambudziko Rakafanana naPasinson's asi Nechirano Chikuru
Apo muimbi weBrithani uye muvakidzani Dudley Moore vakafa musi waMarch 27, 2002, chikonzero chepamutemo chekufa chakanga chakanyorwa sepineumonia. Asi, muchokwadi, Moore ainge achirwa nechinzvimbo chisingawanzozivikanwi anozivikanwa pakufambira mberi kwepranuclear palsy (PSP) iyo inokonzera kuderedzwa zvishoma nezvishoma kwezvikamu zvehupfungwa zvinodzora kuenzanisa, kushandiswa kwemisungo, kugadzirisa kwemaitiro, uye zvimwe zviito zvokuzvidira uye zvisingabatsiri zvakadai sokumedza uye ziso kufamba.
Zvinokonzera Progressive Supranuclear Palsy
Kunyange zvazvo chikonzero chekufambira mberi kwepasyruria palsy zvikuru hachizivikanwe, chakafunga kuti chinosanganiswa nekuchinja kwechimwe chikamu chejeni inonzi chromosome 17.
Zvinosuruvarisa, hazvisi zvese zvisinganzwisisiki kuchinja. Kunyange zvazvo anenge munhu wose ane PSP ane chimiro ichi chinoparara, uyewo, zvikamu zviviri kubva muzvitatu zvevanhu vakawanda. Sezvo zvakadaro, kushanduka kwezviri kuonekwa sekuve kugovera pane kungoita chete chechirwere. Zvinokonzerwa nehutachiona uye zvimwe zvinokonzerwa nemararamiro zvinogonawo kutora chikamu.
Masayendisiti haasati ava nechokwadi zvachose kuti PSP inosanganiswa nechirwere chePalinson kana cheAlzheimer iyo inosangana nezvimwe zviratidzo zvinoratidza.
PSP inofungidzirwa kuti inokonzera mumwe wevanhu vese 100 000 pasinei nedzinza, geography, kana basa. Varume vanowanzotambudzwa zvishoma kupfuura vakadzi. Zviratidzo zvinowanzoonekwa pakati pemakore makumi mashanu nemakumi matanhatu.
Zviratidzo zvePSP
Chimwe chezvinhu zvakanakisisa, "kutaura" zviratidzo zvePSP zvinosanganisira kutarisa kwemaziso, kunyanya kukwanisa kutarisa pasi. Mamiriro ezvinhu, anozivikanwa se ophthalmoparesis, anokonzera kuora simba kana kuora mitezo yemamwe mitsipa yakakomberedza ziso. Kufamba kwemaziso kunowanzobatwa.
Sezvo mamiriro acho achiwedzera, kutarisa kumusoro kunogona kunge kwakagadziriswa.
Pamusana pokushayikwa kwehutungamiri, vanhu vane ophthalmoparesis vachagara vachin'un'una pamusoro pemaonero maviri, maonero asina kunaka, uye kunzwisisa kwekunzwa. Urombo hwakashata hwemaosi hunogonawo kuitika.
Sezvimwe zvikamu zvehuropi zvakakanganiswa, PSP ichazviratidza nemhando dzakawanda dzezviratidzo zvinowedzera kuipa kupfuura nguva. Izvi zvinosanganisira:
- Kusagadzikana uye kurasikirwa kweruzhinji
- Zvose zvinotadzisa kufamba
- Slurring yemashoko
- Dambudziko rokuedza (dysphagia)
- Kurasika kurasika
- Nhengo dzemaziso emasisipo
- Kudonha shure kumusoro nekuda kwekuoma kwemitsipa yemutsipa
- Urinary incontinence
- Kuchinja mune mufambiro, kusanganisira kurasikirwa kwekudzivirira uye kusununguka kwechimbichimbi
- Kuderera kwekuoma uye kusingafungi kufunga
- Kurasikirwa kwehutano hwehutano kana huri kuronga (zvakadai sekutarisa mari, kurasikirwa, kuchengetedza zvipindiro zvebasa)
Kuongororwa kwePSP
PSP inowanzofungidzirwa zvisina kufanira muzvikamu zvekutanga zvechirwere uye inowanzosvibiswa kuhutachiona hwemukati, chirwere chetachiona, chirwere, kana chirwere cheAlzheimer (zvikurukuru kune vakwegura).
Kuongororwa kunoitwa zvichienderana nekuongorora kwezviratidzo. Ndiyo nzira iyo vanachiremba vanoda kuisa kunze kwezvimwe zvinokonzera. A magnetic resonance imaging (MRI) scan ye brain brain inogona kushandiswa kutsigira kuongororwa.
Mune zviitiko zvePSP, pachava nezviratidzo zvekutsvaira (atrophy) muchikamu cheuropi iyo inobatanidza uropi kumutsipa wesipinha. Pamusoro peMRI, rutivi rwemaonero ehuputi uhwu hunogona kuratidza izvo vamwe vanodana "penguin" kana "hummingbird" chiratidzo (chakatumidzwa nokuti chimiro chayo chakafanana neshiri).
Izvi, pamwe chete nezviratidzo, kusiyana kwekutsvaga, uye kuongorora mazita, zvinogona kupa uchapupu hunodiwa kuti uongorore.
Nzira yePSP Inoparadzaniswa Nezvirwere zvePasinsinson
Kuti aparadzanise PSP kubva kuParkinson, vanachiremba vachafunga nezvezvinhu zvakadai sekusimudza uye nhoroondo yezvechiremba.
Semuenzaniso, vanhu vane PSP vachawanzochengetedza kururamisa kana kugadziriswa, apo vanhu vane Parkinson vanoda kuti vave nechepamusoro-mberi.
Uyezve, vanhu vane PSP vanonyanya kuwira nekuda kwekusava nekukwanisa kwekuwedzera. Kunyange zvazvo vanhu vane Parkinson vaine njodzi yakawanda yekuwa, avo vane PSP vanowanzoita kudaro kumashure pamusana pekunyanya kunetseka kwemutsipa uye kugadziriswa shure.
Nezvo zvataurwa, PSP inoonekwa sechikamu cheboka rezvirwere zvinokonzerwa neurodegenerative rinonzi Parkinson-plus syndrome iyo vamwewo vanosanganisira Alzheimer's.
Treatment Options
Hapana hutano hwakananga hwePSP. Vamwe varwere vanogona kupindura mishonga imwechete inoshandiswa kurapa Parkinson, yakadai savodopa , kunyange zvazvo mhinduro inowanzove yakashata (imwe yakasiyana inoshandiswa kuongorora chirwere).
Mimwe mishonga inodzvinyirirwa, yakadai seProzac, Elavil, uye Tofranil, inogona kubatsira nedzimwe zviratidzo zvekuziva kana zviito izvo munhu angave ari kutarisana nacho. Kunze kwemishonga, magirasi chaiwo (zvibatanidza, majeri) anogona kubatsira nematambudziko anooneka, nepo kufamba-famba uye zvimwe zvigadziri zvinogona kugadzirisa kufamba uye kudzivirira kuwira.
Kunyange zvazvo kurapwa kwepanyama kusingawanzovandudzi matambudziko emotokari, vanogona kubatsira kuchengetedza mapuranga emagunha uye kudzivirira kuora kwemisungo nekuda kwekusaita. Mumamiriro ezvinhu akaoma dysphagia, tube yekudya inogona kudiwa.
Zvichida kuiswa magetsi nemhepo inoshandiswa muhupfungwa yakadzika inokurudzira kurapa kwePasinson haina kumbobvira ichishanda mukurapa PSP.
Shoko Rinobva
Pasinei nekushaya kunzwisisa pamusoro pePSP uye zvisarudzo zvisingakwanisi kurapa, zvakakosha kuyeuka kuti chirwere chacho hachina cheitiro uye chinogona kusiyana zvikuru kubva kune munhu kumunhu. Nokutarisira kweutano husingaperi uye kudya kunovaka muviri, munhu ane PSP anogona, chaizvoizvo, kurarama kwemazana, uye kunyange makumi emakumi, achitsvakurudza.
Kune vanhu uye mhuri dzinorarama nechirwere ichi, zvinokosha kutsvaga rubatsiro rwekudzivirira kusarudzwa uye kuve nani kuwana ruzivo rwehutano-hukuru uye hutumira. Izvi zvinosanganisira masangano akadai seNew York City-based CurePSP iyo inopa ma-munhu uye mapoka ekutsigira paIndaneti, nyanzvi yezvechiremba anoongorora, uye ruzhinji rwevadzidzi vanodzidziswa nevamwe.
> Kwakabva:
> Ling, H. "Clinical Approach to Progressive Supranuclear Palsy." Zvinyorwa zveMovement Disorders. 2016; 9 (1): 3-13.