Kubvunzurudza naDkt. Ben Lynch, Nyanzvi yeMTHFR Polymorphisms
MTHFR mutation - kuchinja kune geni iri kuramba ichibatanidzwa kune zvirwere zvakasiyana-siyana-kusanganisira chirwere chetachiona - chiri kuwedzera kukurumidza uye kupopotedzana musoro. Kuti udzidze zvakawanda pamusoro pezvinyorwa uye zvirikuitika zvakabatana neMTHFR - iyo inoshandiswa yejeni inonzi methylenetetrahydrofolate reductase, ndakashandura kuna Dr. Ben Lynch, chiremba we naturopathic uyo akanyanya kufunga nezveMTHFR mapurmorphisms uye kuchinja mazita, uye kusanganiswa kwezvirwere uye mamiriro. Dr Lynch anotarisira nzvimbo, Mthfr.net, iyo yakatsaurirwa kuongororo nekuziva kweMTHFR, uye bhuku rake pamusoro penyaya yacho rakabudiswa muna 2014.
Mubvunzo: Iwe unogona kufanotsanangurira here, kune avo vasingazivi kana kuti vasina kunzwa, chaizvoizvo chirwere cheMTHFR chinonzi?
Dr. Ben Lynch: MTHF gene inobereka enzyme inonzi methylenetetrahydrofolate reductase. Basa reMTHFR enzyme nderekushandura chimiro chema folate mumhando inoshandiswa uye inoshandisika ye folate mumuviri womunhu - mune imwe yese sekipi. MTHFR inotora folic acid uye inoishandura kuitira kuti muviri ishandise. Folic acid pachayo haina zvazvinobatsira - haiti zvachose chinhu - kusvikira ichimhanya kuburikidza nemakemikari akasiyana-siyana mumuviri uye ichichinjwa kuva mhando dzehutano iyo muviri unogona kushandisa - yakadai semethyltetrahydrofolate, kana kazhinji inopfupiswa semethylfolate.
Methylfolate ikamu inokosha inoita mabasa maviri akaoma.
Kutanga, methylfolate inobatsira kuita neurotransmitter muuropi yako. Neurotransmitters ndizvo zvinotibvumira kufunga, kurara, kumhanya, kuratidza manzwiro uye kudzidza. Apo methylfolate mazinga ari pasi, ndizvo zvakaitawo maurotransmitter ako.
Kushandiswa kwemaurotransmitter kunogona kukonzera mamiriro ekunyadzisa, kuora mwoyo, kuzvidya mwoyo, ADHD, mania, kusagadzikana, kusuruvara, zvinetso zvekudzidza nevamwe.
Iviri, methylfolate inotitenderawo kuti tive nechikamu chakakosha chinonzi s-adenosylmethionine - chinonziwo SAMe. SAMe yakakosha sezvo inobatsira kudzora maantimisi anopfuura 200 mumuviri womunhu - uyu wechipiri chete kune adenosine triphosphate (ATP), iyo inhengo yemagetsi emagetsi.
Pasina ATP, upenyu hunopera. Pasina SAMe, upenyu hunopera.
Nekudzikiswa kwemaSAMe , iwe, kana vadikanwa vako, vari pamwero wepamusoro wemamiriro ezvinhu akadai sekenza, kusabereka, kupererwa pamuviri, autism, Down syndrome, thrombosis, kukonzerwa kweropa , matambudziko ekutaura uye zvimwe zvehutano.
Izvo zvakajairika kuti MTHFR gene isashande pamwe chete neinofanira. Sei? Nokuti mumwe muvanhu vaviri ane nzvimbo mune MTHFR gene iro rine DNA yakashata. Iyi shanduko yeDNA inonzi "polymorphism". Izwi rinoreva kuti 'vazhinji' uye rinoreva 'chimiro'. Apo iyo MTHFR geni ine polymorphism, iyo enzyme inobereka inogadzirisa maitiro. Iko kushandurwa kunoita kuderedza simba rinoshanda reMTHFR enzyme. Iko kushandurwa kwebasa kunokonzera kuderedza neurotransmitter basa uye kuderedza kushandiswa kweSAMe.
Mubvunzo: Ndeipi nzira yemethylation uye vanoitei?
Dr. Ben Lynch: Ngatitangei kutsanangura methylation . Methylation ndechiito chekutora imwe kabhoni uye matatu hydrogens, iyo inonzi methyl, uye inozvibatanidza kune enzyme mumuviri wako. Apo boka re methyl rinobatanidza kune enzyme, enzyme inoita chiito. Chiito chinowanzoitwa nemethylation iyo unofarira zuva nezuva ndiko kuparara kwe histamine.
Rimwe boka re methyl rinoshandiswa nemugwagwa we methylation uye inofamba-famba kusvikira yakawana enzyme chaiyo kuti isunge. Munyaya iyi, boka re methyl rinobatanidza ku histamine. Apo boka re methyl rinosungira ku histamine, histamine inoparadzanisa ndokuenda.
Iwe zvino unogona kuverenga zvinenge zvichiitika kana nzira yako yemethylation isiri kubudisa mazana emamethl akakwana munyaya ino. Yako histamine haina kuparadzanisa uye saka histamine yako inowedzera, zvichiita kuti mhino dzako dzimhanyise uye maziso kuve.
Ndeipi basa raSAMe ? Basa reSAMe nderokutora izvo zvinonzi 'methyl boka' uye rinozvipa kune maantimiti anopfuura 200 mumuviri kuitira kuita mabasa akasiyana-siyana akaoma.
Zvimwe zvinonyanya kukosha zveizvi zvakapiwa zvakakwana methyl boka ndezvekuti:
- Dzivirira DNA yako. Izvi zvakakosha chaizvo. Somuenzaniso, kana DNA yako isiri kudzivirirwa, inogona kutyiswa nemavirusi, mabhakitiriya, masimbi ane simba, solvents nevamwe. Nokufamba kwenguva, kukanganisa uku kunova kwakakosha uye kunogona kukonzera kenza yakawanda kupararira. -
- Inoderedza nhengo dze histamine ! Kudzokorora izvi saka inonyura mukati. Rimwe boka re methyl rinopiwa neSAMe rinobatsira kubvisa histamine kubva mumuviri. Vaya vane mishonga inokonzera mishonga kana mashizha vanogona kuva nezvikamu zvakakwirira zve histamine uye vakaderera mapoka e methyl. -
- Itai chinhu chinokosha chemukati membrane yako inonzi phosphatidylcholine. Izwi reMethhyl rinopiwa neSAMe rinobatsira kuvaka phosphatidylcholine iyo inozobatanidzwa mumasvingo emasero ako ose, anozivikanwa senhengo ye membrane. Kana izvi zvikamu zvemasero zvichange zvakuvara uye zvisingakwanisi, masero anova akaoma, anobvumira chekisi uye zvinhu zvinokuvadza muchitokisi, usatakura mishonga inobatsira uye zvino vanofa. Kunyanya kushandiswa kwemasero membrane kukanganisa kunogona kutungamirira kune hutano hwehutano hwakadai sa multiple sclerosis uye kenza kunodudza vashomanana.
Mubvunzo: Wakazive sei nezveMTHFR, uye chii chakakukurudzira kuti uite chikwata chenyu chechikoro?
Dr. Ben Lynch: Rimwe zuva masikati, mumwe mukadzi akandibvunza nezvekurapa kwekuzvarwa kwebipolar disorder. Ndakatanga kusvetuka pane zvose zvinowanzoitika zvezvakasikwa zvekugadzirisa avo vane bipolar disorder. Nokuda kwechimwe chikonzero, ndakafunga kuti mhinduro yangu haina kukwana, zvichida nokuti ndakanga ndabuda kuchikoro chechiremba kwemakore mashomanana uye ndaida kuona kana kutsvakurudza kwakaunza chero chinhu chitsva.
Saka ini ndakarova tsvakurudzo ndikaona kuti vatsvakurudzi vakanga vachiongorora bipolar uye genetics, kunyanya MTHFR. Ndakanga ndisingazivi kuti chii chakaitwa MTHFR saka ndakapinda mu "MTHFR" muchikwata chekutsvakurudza nezvezvokurapa, PubMed, iyo inonzi US National Library yeMishonga yekutsvakurudza dhesi. Ndakashamisika zvakadzokera kwandiri. Anopfuura mapepa 3 000 panguva iyoyo. Iye zvino inopfuura mapeji 5,200 chete paMTHFR chete - uye ichiwedzera.
Sezvandakaongorora mabhuku ekutsvakurudza ne MTHFR mairi, ndakashamisika nematambudziko akawanda akaonekwa. Cleft palate, hypertension, thrombosis , schizophrenia, myocardial infarction ( kurwisa kwemwoyo ), acute lymphoblastic leukemia , kurasikirwa kwekudzivirira pamuviri zvakare - uye izvi zvaingova papeji 1! (Unogona kuzviona iwe pachako!)
Ndakanga ndakashamisika zvikuru kuti handina kumbobvira ndanzwa pamusoro peizvi kuti ini ndakatora 'tweeted' pamusoro peMTHFR - uye handina kumboti 'tweet'. Zuva rakatevera, ndakaputirwa nevanhu vaitsvaga chiremba anoziva nezveMTHFR. Hazvina maturo kutaura, ruzivo rwangu rwakanga rwusiri asi ndakavimbisa kuti ndichadzidza. Kusvikira nhasi, ndinoramba ndichidzidza zvinetso zveMTHFR uye ndinopedza ruzivo rwangu kune vanachiremba.
MTHFR polymorphisms inowanikwa yakawanda uye inokuvadza kumamiriyoni nemamiriyoni evanhu. Asi, nekuziva, avo vane MTHFR mapurmorphisms vanogona kuwedzera mararamiro avo ehupenyu hune utano kana vaingoziva kuti mararamiro avo, zvokudya uye zvekuchengetedzwa kwezvakatipoteredza zvinokurumidza kukonzera ngozi yavo yezvirwere.
Mubvunzo: Utano hupi hunogona kubatsirwa zvikuru nekuziva kweMTHFR?
Dr. Ben Lynch: Zviri nyore - avo vane genetic polymorphism muMTHFR yavo yegene - iyo inoyeuka, ndeyedu muviri wedu. Kunyange avo vasina MTHFR polymorphisms vanobatsirwa kuziva nezvazvo sevanoda kana shamwari vanogona kuva nazvo uye kana vakaitwa vachiziva, vanogona kuchinja hupenyu hwavo zvakanyanya.
Inofanira kurehwa kuti vanachiremba vanofanira kujekeswa kuti MTHFR inokosha sei nokuti ivo ndivo vanochengeta hutano hwemurwere. Nokudaro, zviri kuna chiremba kunoudza murwere uye kuvadzivirira kweMTHFR mapuroymorphisms.
Mubvunzo: Ndiani anofanira kuongororwa MTHFR uye ndeipi?
Dr. Ben Lynch: Munhu wose anofanira kuongororwa. Sei? Nokuti 1 muvanhu vaviri vanobatwa uye kana mumwe achiziva kuti vane MTHFR polymorphism, vanoziva kuti vanotofanira kunyatsoshanda mukuzvitarisira ivo pachavo.
Kuongororwa kweMTHFR kunoda kuonekwa semuedzo wokuongorora. Kana munhu achida kutora pamuviri, anoedza MTHFR. Kana munhu achida kuderedza zvirwere zvinokonzera zvirwere pamwe chete uye kuwedzera hutano hwavo, vanoedza MTHFR. Kana munhu achida kuziva kuti nei mhuri yavo ichiita seine ngozi yakawanda yehutano hwepfungwa, chirwere chemwoyo , kenza, kuora mwoyo kana autism kutumidza vashomanana, vanoedza MTHFR.
Kana iwe ukaswedera kune chiremba wako achikumbira kuti akuratidze iwe MTHFR, zvinhu zviviri zvichaitika. Imwe, haazive kuti ndeyei uye maviri, ivo vachati MTHFR haisi huru yekutengeserana uye hapana chinhu chaunofanira kunetseka nacho - iyo yose fad.
Pachinhu chakanaka iwe une chiremba anofambira mberi, iye zvino, ivo vachakuedzai nokuda kweMTHFR polymorphisms. Shoko rekuyeuchidza apa.
Makambani akawanda einishuwarenzi haafaniri kuvhara MTHFR kuedza uye kana akati ivo vanoita, vanogona kudzoka uye vanokubhadharai mari yakawanda.
Izvozvo zvakati, kune mamwe makambani ekuedza anovimbika kunze uko anoita MTHFR kuongororwa zvakajeka uye zvisingakwanisi uye zvingatove yakafukidzwa nenishuwarenzi.
Iko mbiri inotungamirira makambani ekuongorora MTHFR ndeyeSpectracell Labs uye chero Cheipi Test Test Iye zvino.
Kana iwe usina inshuwarisi, kunze kwemari yehomwe haisi iyo yakaipa, kunyanya kupa zvipo zvinogona kuchinja muupenyu iwe unogona kuwana.
Kuti uwane ruzivo pamusoro pekutsvaga kweMTHFR-pamwe chete nemafungiro ehutsika - dzidza zvakawanda paMTHFR site.
Mubvunzo: Ndezvipi zvirongwa zvako zvepamusoro kune vanhu vane MTHFR mapuroymorphisms?
Dr. Ben Lynch: MTHFR mapuroymorphisms ave aripo kusvika kumarudzi nemazera - uye ari kuendeswa pane imwe nguva nokukurumidza zvichienderana ne folic acid supplementation. )
Ndinotenda kusarudzwa kwakashata muzvokudya, mamiriro asina kunaka, mararamiro anotsvaga, makambani ekubatana uye zviratidzo-maitiro anoita zviri kupa mhedziso yeMTHFR polymorphisms.
Izvozvo zvakati, zvakakosha vanhu vanobvamo uye vanorega kuteerera zvinodhaka zvinodhaka paTV vachikumbira 'Bvunza chiremba wako kana ichi chirwere chakakunakira iwe.' Ndinogona kukuudza ikozvino, hazvisi.
Zvinokurudzirwa pamusoro pomufambiro - uye kukuzivisai kuti ndinoita zvandinoparidza - ndezvizvi:
- Idya zvakakwana, zvakasikwa, zvisingaiti GMO, zvisingawaniki, zvikara zvekudya.
- Rega kuisa chigadzirwa che folic acid supplement uye folic acid inowedzera kudya. Shandisa zvipfeko zvakasikwa zvakadai se folinic acid uye / kana methylfolate.
- Idya zvinhu zvinenge zvakasikwa zvakasikwa zvakadai semashizha asingasviki mashizha. (Hongu - iwe unofanirwa kudya masadhi.
- Inwa mvura yemvura yakasvibiswa - dzivisa mvura yakabhoderedzwa mupurasitiki inosanganisira bisphenol A (BPA).
- Dzivisa marara uye marisi.
- Chiremera chinotarisana nemakemikari munharaunda (kureva formaldehyde mune zvipfeko zvitsva, mapeti, fesheni uye kuvakwa kweimba itsva, uye vanopisa moto mumapfeko, mabhedha, mabheti, makateti).
- Kufuridzira kweBelly.
- Kufunga kwakanaka.
- Kuseka.
- Buda muzvisikwa. Isu tiri, shure kwezvose, zvipfuwo. Usakanganwa izvozvo. Tinoda zvirongwa zvepanyama.
- Ida basa rako - kana iwe usingadi, shandura.
- Ukama - imba inofadza kana ukama hwakanaka,
- Mhuri - tora pamwe nevanodiwa uye unakidzwe navo.
- Shamwari - kugovera uye kugoverana mumabasa.
- Tora zororo.
- Kudzidzira - kunakidza - kwete kunyanyisa. Shingairira mumitambo yemapoka, makirasi.
- Sauna.
- Vaka chikwata chezvechiremba chinofambira mberi, chinotanga kufunga MD, NDs, DOs nevamwe vadzidzisi vehutano.
Mubvunzo: Pane kuwirirana pakati pehutano hwehutano neMTHFR here?
Dr. Ben Lynch: Hungu pane. Isu tose tinoziva kuti yakawanda sei hypothyroidism .
Kana mumwe munhu ari hypothyroid, zvinoreva kuti chirwere chetroroid chinoshanda zvishoma nezvishoma, zvino munhu wacho achava nemhepo inosvibisa MTHFR enzyme pamwe - kunyange kana munhu uyu asina MTHFR polymorphism.
Sei?
Nokuti utachiona hunoita zvinonzi T4, inozivikanwawo se thyroxine . Thyroxine inobatsira kuburitsa maitiro emuviri wemafuta akawanda, flavin adenine dinucleotide (FAD).
Vitamini B2 inofanira kuchinjwa kuva FAD inoshanda ne thyroxine kuitira kuti muviri ushandise zvakanaka vitamini B2.
Kubatana pakati peFAD neMTHFR ndechokuti inonzi MTHFR enzyme inofanira kuva nehuwandu hwakawanda hweFAD kuitira kuti ishande. Kana maFAD ari pasi akaderera pamusana pemazinga ematokisiro ako, ipapo MTHFR enzyme inoderera, zvichiita kuti maitiro e-methylfolate ari pasi. Isu iye zvino tinoziva kubva kumusoro kuti iyo yakaderera methylfolate inotungamirira kumadekari emitambo yakadzika uye pasi SAMe.
Mubvunzo: Chii chinogona kugadziriswa nevarwere, kureva chikafu uye mararamiro ekuchinja, kurarama neMTHFR inhibition?
Dr. Ben Lynch: Hypothyroid varwere vanofanira kunge vane chiremba wavo kuti aongorore TSH, T4, T3, uye utachiona hwehutachiona kakawanda kuitira kuti utachiona huve nani . Kana imwe yeiyo maitiro aripo, ipapo utachiona huchashanda uye huchadaro MTHFR enzyme ichave yakafanana.
Zvinonyanya kukosha kuti vanachiremba vaongorore zvose izvi zviratidzo kwete kwete TSH chete . TSH chiyero pachako hachibatsiri. Izvo zvakafanana kune munhu anokubvunza iwe kuti chii chiripo motokari uye iwe unopindura shure, "Kumusoro uko." 'Kupi?' iwe unobvunza zvakare. Vanopindura zvakare, "Kumusoro uko." Hazvibatsiri kunze kwekuti munhu wacho anonyatsoratidza pane 'pane' kana kuti anotsanangura zviri nani kwauri.
Zvimiti zvinokonzera utachiona zvinosanganisira magnesium, iodine, selenium, zinc uye tyrosine - inobva pakudya - uye inogamuchira - mapuroteni akawanda.
Methylfolate, yakakonzerwa neMTHFR enzyme, inodiwawo kubatsira kubvisa tyrosine muhutachiona hweHroid.
Kuchinja kwemararamiro ehutachiona hwekushongedza utachiona hwako kungadai kuri kuderedza kuwanikwa kweklorini, bromine (bromide), uye fluoride - chaizvoizvo mamwe mahara. Sei? Nemhaka yokuti mamwe maawa aya anofanidza kutengesa kweodhilo iodini , uye izvozvo zvinodzivirira iodini kubva pakusunga kune yakagadzirirwa pane chirwere chako chetrojeni.
Kana iwe uine mamwe maawa ekutapira kwako kwetroroid, iodine inofanirwa kunge yakasungwa sei? Zvinonetsa - kunyanya kana imwe iodine isina kukwana uye vamwe vakadzi vekuAmerica vanoshaya iodine .
Taura nachiremba wako nezvekuongorora mazinga eodhini uye kuwedzera zvakakodzera kana zvichidiwa.
Ndinokurudzira kuisa mafirati echlorine shower yewaini yako, kuchenesa mvura yako yekunwa, kuvharidzira kuratidzwa kwe fluoride, nekudzivirira kana kudzivisa kunwa soda, sezvinonzi macrorus sodas akawanda ane brominated yemafuta yemafuta.
Kushanduka kwezvakatipoteredza kunodzivirira utachiona hwako kwaizove kurega masimbi akaremara akadai se mercury. Mhemberero nedzimwe nhepfenyuro dzine simba zvinonyanyisa zvikuru kune utachiona. Mercury amalgams inotsvakurudzwa kuti iwedzere kukuvadza mukukonzera chirwere chaHashimoto.
Chikafu chinopararira chinokanganisa utachiona hwako ndeye gluten. Kubvisa gluten zvachose kubva pakudya kwako kunogona kuchinja zvakanyanya thyroid yako . Izvi zvinoreva 100% kudzivisa - kusanganisa kamwechete pavhiki kana kamwe kamwe pamwedzi - kupedzisa zvakakwana. Izvi zvinonyanya kukosha kana iwe une chirwere checliac.
Mubvunzo: Ungatiudza nezvewebsite yako yeMTHFR.net?
Dr. Ben Lynch: Ndinoita basa rangu rechikoro. Kana ndichitaura chimwe chinhu, ndinotsvaga tsvakurudzo kana ini ndichinyatsotaura kuti inyanzvi inoshanda. Handifungi kuti ndinoziva chimwe chinhu chandisina. Kana ini ndisingazivi chimwe chinhu, ini handisi kunyora kana kuita mhinduro, ndinongotaura mazwi matatu - "Handizivi."
Kana vanhu vakamira uye vachinzwisisa kuti "Handizivi" kwakanaka uye kunobatsira, saka mushonga pamwe nedzimwe nzvimbo dzehupenyu huchava nani zvikuru.
Ndinogara ndichiverenga - uye ndichiongorora zvakadzama - kupedza mapeji ekutsvakurudza emhepo pamusoro peMTHFR, methylation, nutrigenomics, imwe carbon metabolism, mitochondrial basa uye epigenetics. Ndinoda zvandiri kuita uye ndakanyatsopindira uye ndinoshushikana nazvo zvakare. Sei? Nokuti ndinoziva kuti zvichinja kuti mishonga inoitwa sei.
Nzira yezvokurapa nhasi ndeye inoda kukanganiswa kunze kwehwindo. Chiratidzo-chirwere chakachengetedzwa muenzaniso hachina basa uye vanachiremba vanoziva izvi. Vari kutendeukira kune naturopathic uye mushonga unoshanda. Chinetso ndechekuti vanachiremba vanoramba vachiita chimiro chimwe chete-chirwere chakachengetedzwa mumashandisi ekushandisa zvidimbu, maruva nezvimwe zvinokonzerwa panzvimbo yezvinodhaka nekuvhiya. Hungu, uku ndiko kugadziriswa kwenguva yakawanda asi hachiri kutarisana nechikonzero chakakwana chechikonzero nei murwere wavo achirwara.
Ndiri kudzidzisa vamwe vanachiremba pamusoro pemuenzaniso mutsva unobuda kubva pane izvi zvose uye izvo zvinonzi biochemical nutrigenomics. Apo chiremba anonyanya kurarama mararamiro emurwere, kudya, nzvimbo dzakakomberedza, zvido zvekuita, manzwiro emuviri, biochemistry, genetics uye mazwi ekutaura, zvino zvinhu zvinoshamisa zvinoitika. Ingobvunza madhaini avo vakamboenda kune dzimwe dzandawanda. Dzidzo yekuvhara yakanyanyisa uye inorwadza, asi zvakakosha nokuti kana wadzidza, unoenderera mberi kuchikwanisa uye varwere vako vanokurumidza kukurumidza - nekukurumidza.
Hapana chinhu chiri nani kune chiremba iye zvino anofanira kuisa chiratidzo kunze kwemukova wepamberi - "Varwere vanoda. Zvose zvangu zvangu zvine utano. "
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Dr. Ben Lynch chiremba we naturopathic uyo akaisa pfungwa dzake mukutsvakurudza uye kudzidzisa paMTHFR polymorphisms uye kuchinja mazita, nekubatana nezvirwere. Dhiyabhorosi Lynch's site http://mthfr.net inoita tsvakurudzo, nenyaya, hukama uye ruzivo rwakabatana neMTHFR genetic mutations uye mapurmorphisms. Bhuku rake panyaya iyi richave riripo mukati megore ra2014 panzvimbo ino, uye mabhuku ezvitoro paIndaneti. Unogonawo kuwana Dr. Lynch pa Facebook.