Kuongorora chirwere chetachiona inzira inogona kusanganisira zvinhu zvakawanda, kusanganisira kliniki yekuongorora, kuongorora ropa, kuongorora, kuongorora zviratidzo, biopsies, nezvimwe zviedzo. Muchikamu chino, unodzidza zvakawanda pamusoro pekusiyana kwekuedzwa kweropa kunoshandiswa sechikamu chetachiona chirwere chekuongorora , kurapwa, nekuenderera mberi nekutevera uye kutungamirirwa.
TSH Test
Chirwere chetachiona chinowanzojairika ndechekuyera ropa iyo inoyera yakawanda yehutori-stimulating hormone (TSH) muropa rako.
Muedzo dzimwe nguva unonzi thyrotropin-stimulating test hormone.
TSH iyo yakakwirira, kana pamusoro pemazuva ose, inonzi inoratidza hypothyroidism. TSH iyo "inodzingwa" kana pasi pezvakanaka, inoonekwa sehupupu hwe hyperthyroidism.
Pari zvino, iyo inotarisa inotarisa inotangira kubva ku-0.5 kusvika ku-5.0. Mazinga ari pamusoro apa 3.0 ndiwo uchapupu hwezvinobvira hypothyroidism, uye mazamu ari pasi apa 0.5 ndehupi hwehutano hwehutano hwehutachiona hunoita. Cherechedza kuti ruzivo rwakatarisa rwakasiyana rwevakadzi vane pamuviri .
Tsvaga zvakawanda nezvekuedza kweTSH.
Free T4 / Free Thyroxine
Thyroxine, hormone yakagadzirwa nehutachiona, inonziwo T4. T4 yakasununguka inotora mahwindo, asina kuwedzera thyroxine mahara muropa rako. Free T4 inowanzokwidziridzwa mu hyperthyroidism, uye inoderedzwa mu hypothyroidism.
Mahara kana kuti asina kutenderera mazinga T4 anomiririra huwandu hwehomoni inowanikwa kuti iwedzere uye inoshandiswa nemasero. Kuvhara mazana kunomiririra hormone inogona kunge isiri iyo yose iripo pakarepo, nokuti inobatwa nedzimwe mishonga, urwere, uye kuchinja kwemuviri sekuita pamuviri.
Nemhaka yokuti mahara akasununguka eT4 anomiririra iyo chaiyo yehutoni inowanikwa, isina T4 inofungidzirwa kuti inofanirwa kuratidza hutachiona hwehutachiona kupfuura huwandu hweT4 (pasi).
Zvose T4 / Total Thyroxine / Serum Thyroxine
Uyu muedzo unoyera kukosha kwehuwandu hwe thyroxine muropa rako. Kukosha kwakanyanya kunogona kuratidza hyperthyroidism, kukosha kwakanyanya kunogona kuratidza hypothyroidism.
Zvose T4 mazinga anogona kukwidziridzwa nekuda kwekuita pamuviri, uye mamwe mahedheni makuru eesrogen, kusanganisira kushandiswa kweesrogen kana kuti mapiritsi ekudzivirira kuberekwa .
Free T3 / Free Triiodothyronine
Triiodothyronine ndiyo inoshandisa utachiona hormone , uye inonziwo T3. T3 yakasununguka inoyera mahara, asina kuwedzera mazinga e triiodothyronine muropa rako. Free T3 inonzi yakarurama kupfuura Total T3. Free T3 inowanzokwidziridzwa mu hyperthyroidism, uye inoderedzwa mu hypothyroidism.
Zvose T3 / Total Triiodothyronine
Zvose T3 zvinowanzokwidziridzwa mu hyperthyroidism, uye inoderedzwa mu hypothyroidism.
T3 Resin Uptake (T3RU) / T7
Kana kuongororwa ropa kuchiitwa neT3 neT4, kuongorora kweT3 kutinha (T3RU) dzimwe nguva inonzi inonzi T7 muedzo. Uyu muedzo unoyera chiyero chesaturated zvisungo zvakasungirirwa pakutakura (kusunga) mahomoni. Yakakura T3RU inowanzoonekwa ne hyperthyroidism.
Thyroglobulin / Tg
Thyroglobulin (Tg) ipuroteni inoberekwa nehutachiona. Nhamba dzeTg dzakadzika kana dzisingaonekwi nehutano hwehutano huripo asi hunogona kuwedzera mu thyroiditis, chirwere cheGraves, kana kanstro yekameti. Kuongororwa kwemaTg maitiro kunowanzoshandiswa kuongororwa kubudirira kwehutano hwekenza yekenza uye kutarisa kuti chirwere chekenza chidzoke zvakare.
Kudzorera T3
Kana muviri uri mukutambudzika, panzvimbo yekutendeutsa T4 muT3 - iyo inoshandiswa yehutoni yehomoni - muviri unochengetedza simba kuburikidza nekuita izvo zvinozivikanwa seReverse T3 (RT3), chimiro chisina kushandiswa cheT3 hormone. Kukosha kweR33 kuongororwa kunoongororwa kunopesana, sezvimwe vashandi vanofunga kuti muviri unoenderera mberi kuumba RT3 panzvimbo yekushanda T3, zvichikonzera kukanganisa kwakakosha mumatambudziko anonzi T3 thyroid hormone.
Thyroid Peroxidase (TPO) Antibodies (TPOAb) / Antithyroid Peroxidase Antibodies
Thyroid Peroxidase (TPO) antibodies, inonziwo Antithyroid Peroxidase Antibodies.
(Kare, ma antibodies ainziwo Antithyroid Microsomal Antibodies kana Antimicrosomal Antibodies).
Izvi zvinorwisa utachiona peroxidase, iyo enzyme inotora chikamu muT4-kusvika-T3 kutendeuka nekugadzirisa maitiro. TPO masimba anokwanisa kuva uchapupu hwehutachiona hwekuparadza, hwakafanana nechirwere chaHashimoto, uye zvisiri zvishoma, mune mamwe maitiro etiroiditis zvakadai se post-partum thyroiditis.
Inofungidzirwa kuti TPO inorwisa zvirwere inogona kuonekwa munenge 95 muzana yevarwere vane Hashimoto's thyroiditis, uye 50 kusvika 85 muzana yevarwere veGraves '. Kuwedzera kwezvirwere zvinowanika mune varwere vane chirwere cheBraves kazhinji chinoderera kupfuura kune varwere vane chirwere cheHashimoto.
Thyroglobulin Antibodies / Antithyroglobulin Antibodies
Kuongororwa kwezvirwere zve thyroglobulin (inonziwo antithyroglobulin antibodies) inoshandiswa kuongorora zvikonzero zvinokonzerwa nehutachiona. Kana iwe watoona kuti une chirwere cheGraves, kuva nehupamhi hwejeri yako thyroglobulin zvinoreva kuti iwe unowanzopedzisira wava hypothyroid. Thyroglobulin antibodies yakanaka mune anenge 60 muzana yevarwere vaHashimoto uye 30 muzana yevarwere vaGerves.
Utachiona-Kukurudzira Immunoglobulins (TSI) / TSH Stimulating Antibodies (TSAb)
TSH receptor antibodies (TRAb) inowanikwa mune varwere vakawanda vane nhoroondo ye, kana kuti ndiani iye zvino, Graves 'chirwere. Kuedzwa kunowanzoitwa kune imwe rudzi rweTrAb rinokurudzira rinoenda nemazita akasiyana-siyana, kusanganisira:
- Utachiona-Kukurudzira Immunoglobulins (TSI)
- TSH kukurudzira zvirwere (TSAb)
Utachiona-stimulating immunoglobulins (TSI) inogona kuonekwa mumuzhinji wevanhu vane chirwere cheBraves, uye kuenzanisa kunowanikwa kune vakawanda kusvika 75 kusvika ku90 muzana yevarwere veGeral's disease. Iyo yakakwirira mazinga, iyo inoshanda zvakanyanya kuGraves 'chirwere inofungidzirwa kuva. (Kushayikwa kwezvirwere izvi hazvirevi, kunze kwechirwere cheMakuva.)
Zvishoma nezvishoma, vamwe vanhu vane chirwere cheHashimoto vanewo ma antibodies, uye izvi zvinogona kukonzera nguva dzenguva pfupi dzenguva shoma dze hyperthyroidism.
Kana kutarisa TSI, zvikwata zvakakwirira zvinogona kubatsira kufanotaura kudzokororazve kwechirwere cheMakuva, uye kuderedza mazinga eTSI kungaratidza kuti chirwere cheGerves ' chinoshanda.
Kutarisana kweTSI kunonyanya kukosha panguva yekudzivirira, nokuti mizinga yakakwirira, kunyanya pakuberekwa kwepakutanga uye panguva yechitatu yemamiriyoni, inokonzerwa nehutachiwana hwekutal kana neonatal thyroid. Madzimai anonzi TSI anokwanisa kutamira kune mwana asati aberekwa kuburikidza ne-placenta, achiita mwana hyperthyroid mu utero, kana pakuzvarwa. Kutsvakurudza kwakaratidza kuti vazhinji vanenge 10 kubva muzana yevakadzi vane pamuviri vane TSI yakakwirira vanounza vana vane hutano hwehutachiona husingaperi.
Sources:
Braverman, MD, Lewis E., naRobert D. Utiger, MD. Werner uye Ingbar's The Thyroid: Chimwe Chinokosha uye Chirongwa Chekunyora. 9th ed. , Philadelphia: Lippincott Williams & Wilkins (LWW), 2012.
Roti, Elio, uye. al. "TSH Receptor Antibody Measurement muKutsvaga uye Kutungamirirwa kweMarinda 'Kurwara Kwacho Kunokosha," Journal of Clinical Endocrinology & Metabolism, Vol. 83, No. 11 3781-3784 http://jcem.endojournals.org/cgi/content/full/83/11/3781
Spencer, Carol. "Kurapa kweTyroid Hormones uye Zvimwe Zvinhu," Mutungamiri weKiroid . February 6, 2004. http://www.thyroidmanager.org/chapter/assay-of-thyroid-hormones-and-related-substances/