Zvinogadziriswa neMuviri Wako Zvikamu Nezvaunotakura
Ko itsvo dzako, mwoyo kana kunyange mazamu ako angave akwegura kupfuura muviri wako wose here? Imwe tsvakurudzo inoratidza kuti haisi zvikamu zvose zvezera remuviri panguva imwe chete . Kuwanikwa - kana kuri kuramba kuchipa chiyero chekufungidzira kwekukurumidza kwemasisita ekukwegura - zvingaguma zvabatsira masayendisiti kunonoka kana kuchinja zvakare kukwegura.
The Timekeeper Within Cells
Imwe nyaya yakabudiswa mumagazini yaGenesis Biology muna 2013 inotsanangura kuti maitiro emasikirwo evanhu anowanikwa mukati memusero anogona kushandiswa sechimiro chekuchengeta nguva kana kuti kudikanwa kwekurumidza kushandiswa kweiyo.
Iyi nzira, inozivikanwa se methylation, inoshandura DNA - maitiro ekugadzirwa kwemasero emasero - mune muenzaniso unoenderana nekukwegura.
Mberi kutsvakurudza paYunivhesiti yeCalifornia kuLos Angeles (UCLA) yakashandisa saliva samples kubva pamapakati maviri emapatya akafanana kuratidza kuti zvipi zveDNA zvakabatana nemhyhylation zvakavimbika kusvika panguva yezvidzidzo. Masayendisiti akazoongorora maitiro e-methylation muhuwandu hwevanhu uye vakakwanisa kuvhara makore evanhu vakura mumakore mashanu, achishandisa sarva yemunhu chete.
Steve Horvath, aUCLA vanhu genetics uye biostatistics purofesa, akatora tsvakurudzo iyi mberi uye akaongorora zvinopfuura 8 000 zvinyorwa uye masero masero anopiwa nevamwe vasayendisiti. Zviratidzo zvevanhu zvakatorwa kubva vasati vaberekwa kusvika makore makumi mapfumbamwe nemashanu, kune dzinopfuura 50 marudzi akasiyana-siyana emasukisi nemasero kubva kumativi akasiyana emuviri, kusanganisira chiropa, impso, uropi, mapapu, uye mwoyo. DNA inonzi methylation yakawanda inogadzira manyorerwo akaenzana ekuti nokukurumidza maitiro akasiyana-siyana akanga akwegura sei.
Horvath nevamwe vake vakashandisa chiyero chekuyera kutarisa kwekukwegura mu 6 000 saratani dzakasiyana-siyana dzekenza , zvinomiririra marudzi makumi maviri ehutachiona.
Zvimwe Zvikamu zveMuviri Wezera paZvinyorwa Zvimwe
Tora yaHorvath yakawana kuti mazamu akawanda ezera rakanaka chaizvo zvakafanana; iyo chaiyo, nguva yavo yezvakaberekwa , kureva kuti iyo yakanyatsoshanda sei, inofanidza nguva yavo yezviitiko , kureva nhamba yemakore inomiririrwa pane kendendende.
Chirwere chepabonde, zvisinei, chakanga chisingaiti. Utano hwakanaka hwepamuviri hwakawanda nekukurumidza uye hunenge huri pamakore maviri kusvika matatu kupfuura humwe humwe muviri wemukadzi. Izvi zvinogona kutsanangura kuti sei kenza yemvere ndiyo inonyanya kufanana nekenza yevakadzi muhutano ichinhu chinokonzera mungozi uye zvakanyanya kukurumidza-tema tissue zvingadaro, zvinowedzera kuve nekenza.
Madzimai avo vane kenza yepazamu, kukwegura kwakakurumidza kunyanya kutaurwa. Kuedza zvipembenene zviri pedo nemamera emuchiramu wepabonde, vatsvakurudzi vakawana kuti paive nemakore anenge gumi nemakore kupfuura imwe yose yemuviri.
Inowedzera Kukura Maseku Anonyanya Kuita Kenza Here?
Zvirwere zvinouraya zvakawanikwa kuti zvakakura kudarika mishonga ine utano yakawanikwa kune imwe nzvimbo mumuviri. Dare rekutsvakurudza rinodzidza marudzi anopfuura 20 akasiyana nekenza uye yakawana zviratidzo zvisingagumi zvekukwegura nekukurumidza muzvirwere zvinorwara. Zvechokwadi, mishonga yekenza yaiva yevhareji yemakore makumi matatu nemasere kupfuura imwe yose yemuviri.
Izvi zvinomubvunza mubvunzo unokosha: Masero ari kukwegura anokurumidza kukurirwa nekenza here kana kuti chirwere chezera remakore rinokurumidza sei? Horvath anotsanangura kuti zvose zvezvinhu izvi zvingava zvechokwadi. Semuenzaniso, mumatambudziko akawanda emukenza, mishonga iri pedyo inotarisa vaduku, kana kuti inguva chaiyo yevanhu iyo sampuli dzaibva, izvo zvinoratidza kenza pachayo kumakore masero.
Ichokwadi kuti kunyange hutano hwakanaka hunoita sehukuru hunofanana nehutachiona hwemethylation kana huchienzaniswa nehumwe humwe muviri hwemukadzi hunoti humwe hunyanya kukurumidza-hutundu hunove hunogona kutarisana nekenza.
"Ongororo dzakawedzerwa dzichadikanwa kuti uedze iyi pfungwa," anodaro Horvath. "Tinoda chaizvo kuenzanisa nguva yeutano hwakanaka, isiri yemahara yepamuviri yepfupa." Uyezve, tinoda kuongorora kana kuwedzerwa kwezera mukati memafupa emvere kunofanirwa kukura kwekenza pane imwe nguva. "
Kunyanya kuongororwa kwehutano hwetano hwakanaka muzvikamu zvakasiyana-siyana muupenyu hwomukadzi - kuyaruka, mushure mekusununguka, mushure mokunge avete pamuviri uye mushure mokunge apera shure - kuchabatsira kubvisa kana mvere dzemazamu dziri kukurumidza kukurumidza, chaizvoizvo, dzinowanzova nekenza.
Kana zvakadaro, kuedza dhigiriyumu mukati mezvifuva rimwe zuva rinogona kutora mukana wevakadzi wokuwana chirwere ichi chinotyisa.
Telomeres
Telomeres inopa imwe nzira yekuyera kukwegura kwemari. Telomeres zvivako zviduku zvinokonzera mazamu emagetsi zvakapoteredza musero sezvo sero rinogadzirira kugovana. Nguva imwe neimwe sero sekuparadzana kunoitika, tereomere dzinopfupisa zvishoma; kamwe pavanenge vashoma kwazvo, sero haigoni kugovana, zvichiita kuti sero kufa.
Pane kutsvakurudza kunoitwa kuti uone urefu hwetereomere sechirongwa chechinangwa chekufunga kwekuti masero mashoma mumuviri wako ari kukwegura sei. Mukuwedzera, masayendisiti ari kuongorora kana kuchengeta tereomeres kwenguva yakareba kunogona kuchengetedza masero ediki nekuparadzanisa zvakanaka.
Sources:
Methylation. US National Cancer Institute Dictionary yeCancer Terms. Yakasvika pana Gumiguru 25, 2013.
http://www.cancer.gov/dictionary?cdrid=655031
Steve Horvath. "DNA inonzi methylation yemakore evanhu uye masero." Genome Biology 2013, 14: R115.
http://genomebiology.com/2013/14/10/R115
Sven Bocklandt, Wen Lin, Mary E. Sehl, Francisco J. Sánchez, Janet S. Sinsheimer, Steve Horvath, naEric Vilain. "Epigenetic Predictor Age." PLoS ONE 6 (6): e14821.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0014821