Biologic Zvinodhaka Zvisingaenzaniswi Zvakakosha kune Munhu Mumwe Nemwoyo Murefu
TNF (tumor necrosis factor) blockers yakave nzira yekurapa kune varwere vane rheumatoid arthritis kana chimwe chimwe chirwere chinokonzera arthritis kutanga muna 1998 apo Enbrel (etanercept) yaiva FDA yakagamuchirwa. Zvimwe zvinodhaka zvebiologic kubvira kare zvakagamuchirwa uye zvinotengeswa.
TNF blockers dzinosanganisira, Enbrel (etanercept), Remicade (infliximab), Humira (adalimumab), Simponi (golimumab) uye Cimzia (certolizumab pegol).
Kunewo mamwe madhizimusi emishonga, zvakadai seOrencia (abatacept), Rituxan (rituximab), Actemra (tocilizumab), uye Kineret (anakinra) iyo isingatarisi TNF.
Kana iwe uri kurapwa nevharivha yeTNF, zvinogona kudiwa kuti uende kune rimwe rega rega reNENF kana chimwe chirwere che biologic pane imwe nguva. Zvikonzero zvakakodzera zvekuchinja zvinogona kusanganisira:
- Kusagutsikana kwekupindura kwekurapa
- Zvisingabatsiri migumisiro yechirwere
- Kubudirira kuderedzwa kwenguva
Takabvunza rheumatologist Scott J. Zashin, MD mibvunzo mashomanana pamusoro pokushandura yako TNF blocker.
- Zvinokwanisika here kuti murwere ave nemhinduro yakanaka pane imwe nzvimbo yeTelcker yakasiyana kana kuti yose yakafanana?
- Ko murwere angadzoka zvakare pavhara reTF mushure mekunge amira?
Dr. Zashin akapindura achiti, "Inenge 70 muzana yevarwere vane rheumatoid arthritis vanotanga imwe yeNADF blockers ichawana kuwedzera kwakanyanya mumamiriro avo.Vamwe varwere vachawana rubatsiro apo methotrexate (Rheumatrex, Trexall) kana imwe DMARD (zvirwere-kuchinja anti-rheumatic drug) inosanganiswa neTFF blocker.
Kana murwere asingateereri pavhareji yekutanga yeTF mushure memwedzi mitatu, kushandura kune imwe kuwedzera mukana wavo wekubatsirwa. Zvechokwadi, kunyange kana murwere asina kupindura kune zvemadhidhi maviri eETM, zvinogona kunge zvichiri kubatsira kuedza chechitatu. "
Sezvakangoitika, mitsva yekudzidza (yakabudiswa munaJune 2010 muna Rheumatology) yakagumisa kuti varwere vane spondyloarthritis vakakundikana kupindura Enbrel ye Remicade seyekutanga vashandi, vakapindura Huma mushure mekunge vashandura, pasinei nokuti nei vakashandura.
Chimwe chidzidzo chinonakidza, chakabudiswa muCliniki uye Ongororo Rheumatology muna 2013, chakajekesa kuti varwere vane spondyloarthritis vakakwanisa kugara kwenguva yakareba neNATF blockers kupfuura rheumatoid arthritis varwere, kunyanya nekuda kwe ankylosing spondylitis subgroup yevarwere. Izvo zvose rheumatoid arthritis uye spondyloarthritis, varwere vakakwanisa kumira pamwe neEbrel uye Humira kwenguva yakaenzaniswa neRicicade.
Dr. Zashin akawedzera, "VaRheumatologists vakawanda havana kushandisa Kineret kurapa rheumatoid arthritis pamusana pekuita kwayo kuderera uye kunoda kuvharwa zuva rega rega. Zvisinei, Kineret yakabatsira zvikuru kune avo varwere vakaonekwa kuti vane urongwa hwehutano hwevana vechirwere, chinonzi Chiri chirwere . "
Uyewo, maererano naDkt. Zashin, apo varwere vakasiya kurapa naEbrel naHumira vanogona kudzoka zvakare kumushonga pasina hanya, avo vakambobva Remicade kwenguva yakareba vari kutarisana nehutachiwana hwekuvhiringidza kunogona kuve nengozi.
Sources:
Kushanduka kubva ku infliximab kana etanercept kune adalimumab mukurwisana kana kuvhiringidza varwere vane spondyloarthritis: chidzidzo chegore 4. Spadaro. A. et al. Rheumatology (Oxford). June 2010.
http://www.ncbi.nlm.nih.gov/pubmed/20223813
Kuponeswa kwezvinodhaka zvekambani yekutanga yevanorwisa-TNF vashandi mune varwere vane rhumumidhi arthritis uye seronegative spondyloarthritis: kuongorora kubva kune database ye MonitorNet. Scire CA uye al. Clinical uye Ongororo Rheumatology. November-December 2013.
http://www.ncbi.nlm.nih.gov/pubmed/23981363
Mhinduro, muchikamu, yakapiwa naScott J. Zashin, MD, purofesa wechipatimendi wechipatara paYunivhesiti yeTexas Southwestern Medical School, Division of Rheumatology, muDallas, Texas. Dr. Zashin zvakare ari kuenda kuchiremba muPresbyterian Hospitals yeDallas uye Plano. Iye ishamwari yeAmerican College of Physicians uye American College of Rheumatology uye nhengo yeAmerican Medical Association. Dr. Zashin munyori weArthritis Pas Pain - Mirairo yeAnti-TNF Blockers uye mubati wenhengo yeAtmal Arthritis Treatment.