Tumor Necrosis Factor Inokonzera Kurwiswa
Tumor necrosis factor (TNF) chinhu chinobudiswa nemasero ari mumuviri wako ane zvirwere zvakawanda mukusimudzira kupisa . Inoberekwa zvakanyanya nema macrophages, rudzi rwechichena cheropa, asi rinogona kugadzirwa nemamwe masero.
Tumor Necrosis Factor mumhinduro ye Immune
TNF chikamu chechisikigo chemuviri wemuviri wemuviri kune tumor cells, mabhakitiriya, uye mavairasi.
Inobatanidzwa chikamu mumatauriro akaoma uye kuvhiringidzika kwetsika. Masero anosunungura iyo paanoona chimwe chinhu (an antigen) chavanenge vadzidziswa.
TNF is cytokine , a signaling protein. Cytokine makemikari zvinhu anotumira mashoko pakati pemasero ari mumuviri. Vanotora chikamu mune zvakawanda zvirongwa zvehupenyu, kusanganisira:
- Kukura kwemafoni
- Apoptosis, iyo yakarongeka yekufa kwesero
- Lipid (mafuta) metabolism
- Kubatana, kana kuumbwa kwemafupa eropa
Tumor Necrosis Factor muDaase
TNF inogona kubudiswa zvakanyanyisa kana kuti zvisina kukodzera mumatambudziko akasiyana-siyana. Izvi zvinogona kuguma nekuputika kwechirwere uye zvimwe zviratidzo zvinoparadza. Izvi zvirwere zvinosanganisira:
- Kurwisa zvirwere zvakadai se rheumatoid arthritis
- Insulin kushorwa
- Cancer
Tumor Necrosis Factor uye Rheumatoid Arthritis
Tumor necrosis factor-alpha ndeimwe yemaktokines anokosha zvikuru anobatanidzwa mune rheumatoid arthritis kuburikidza nekubatanidzwa kwaro mukudengenyeka kwezvakaitika.
Kazhinji, muviri unovhara TNF yakawanda. Asi mune chirwere cherheumatic, chinoramba chichishanda uye chichiwedzera kuvhiringidza. TNF blocker zvinodhaka zvakagadzirirwa kutarisa kupindura uku kupisa.
TNF Inhibitor Zvinodhaka
Vanhu vane hutano hwakadai saRheumatoid arthritis , psoriatic arthritis , uye chirwere cheCrohn chinogona kurapwa neNTF inhibitor zvinodhaka.
Iyi mishonga inosunga kumarara necrosis factor-alpha, ichiita kuti irege kushanda. Izvi zvinopesana nebasa rekuvhiringidza uye rinoderedza muviri wako wekuzvidzivirira. Kune vanhu vane rheumatoid arthritis, izvi zvinogona kuderedza kusanganisa pamwe chete. Mushonga wekutanga wakagamuchirwa muna 1998 uye zvimwe zvakagadzirwa. Ivo vari mukirasi yemishonga ye biologic , iyo inoshandiswa mishonga inoshandisa mamolekemu pane masero ezvirwere zvemuviri.
TNF inhibitor zvinodhaka zvinosanganisira:
- Enbrel (etanercept)
- Remicade (infliximab)
- Humira (adalimumab)
- Simponi (golimumab)
- Cimzia (certolizumab pegol)
Achishandisa TNF Inhibitors
TNF blockers havatorwa nomuromo. Pane kudaro, unofanira kuzvivhara pasi peganda rako kana kupinda mumhino dzako, kazhinji muhudyu yako kana mudumbu. Maererano nemishumo yevarwere, kuchinja kwezviratidzo zvako kunotanga kuitika mushure mematatu maviri kana matatu.
Kana chiremba wako akaraira chirwere cheNNA chine jira, iwe uchadzidziswa nzira yokuzvidzivirira iwe iwe pachako saka haufaniri kuenda kuhofisi yechiremba nguva nenguva.
Kana chiremba wako achinyora infliximab kana golimumab, iwe unofanira kuenda kune imwe nzvimbo yekuisa mukana kana kuti hofisi yechiremba kwemaawa matatu kuti uwane mushonga wako. Iyi mishonga haisi injodzi.
Migumisiro Yechipfuva Nechirwere Necrosis Factor Inhibitors
TNF blockers inogona kukonzera madhara.
Chinhu chinonyanya kupararira chine nzvimbo yejojo inopindira, iyo inowanzowanikwa mumhepo yakaperekedzwa pamwe chete nekutsva kwekutsva kana kuchenesa.
Nengozi yakawanda yehutachiona hwehutachiona ndiyo inonyanya kukosha kuitika kweNADF blockers nokuti inodzivisa masimba ako ezvirwere. Ita kuti chiremba wako akuedze iwe nehutachiwana uye hepatitis B usati watanga kurapwa.
> Sources:
> Mashoko pamusoro peTumor Necrosis Factor (TNF) Blockers (Inotengeswa seRumicade, Enbrel, Humira, Cimzia, uye Simponi). US Food and Drug Administration.
> TNF Inhibitors. American College of Rheumatology.
> TNF Tumor Necrosis Factor Muvanhu. National Center ye Biotechnology Information.