Chii chinonzi Glutamate?
Tsanangudzo:
Glutamate rudzi rwemakemikari emakemikari anonzi neurotransmitter , zvinoreva kuti rinobatsira kutumira mameseji akapoteredza uropi. Zvinowanzobatanidzwa mukudzidza nekuyeuka. Glutamate inobatanidzwawo mune zvirwere zvakawanda zvehutano.
Uyewo Anozivikanwa Se: L-glutamic acid, glutamic acid, L-glutamate
Kazhinji Kuvhiringidzwa Na: Glutamine
Glutamate inoita mamwe mabasa anokosha muuropi yako.
Inonzi inonzi neurotransmitter yekunakidza, iyo inoreva kuti inokurudzira nzvimbo muuropi kana zvimwe zvikamu zvehurongwa hwekutya. Izvozvo zvinokurudzirwa chikamu chinokosha chekudzidza, saka nenzira iyoyo, glutamate chinhu chakanaka.
Kunyange zvakadaro, zvakawanda zve glutamate hazvisi izvo zvaunoda. Mune zvimwe zviitiko, zvinogona kuva izvo zvinonzi "excitotoxin". "Toxin" haisati iri shoko rakanaka, uye zvechokwadi haisi chakanaka munyaya iyi. Mune basa rayo se excitotoxin, glutamate inogona kupfuudza zvakanyanya masero ako europi.
Kana kukwirira kwepamusoro kuchienda kusingabvunzwi, iyi yeurotransmitter inogona kupfurikidza nemasero iwayo kusvika pavanotora matanho makuru uye kuzvipira kuzviuraya kuitira kuti dzidzivirire masero akavapoteredza. (Funga nezvazvo sekutora mazino anoora kuitira kuti kuora kusapararira kune meno ari pedyo nayo.)
Maseji ari mumuviri wedu anofa nguva dzose, uye akawanda acho anogona kushandiswa. Izvo izvo glutamate zvinotungamirira kuzviuraya, zvakadaro, ndeyeuroni.
Uropi hwako haugoni kuita hutsva kuti huve panzvimbo yeavo vakarashika, saka zvakakosha kuti ugare wakave wakagwinya uye wakachengeteka.
Basa reGlutamate se excitotoxin rinotendwa richibatanidzwa mune zvakasiyana-siyana zvinokonzerwa neurodegenerative zvakadai se multiple sclerosis, chirwere cheAlzheimer uye amyotrophic lateral sclerosis (inonzi ALS kana kuti Lou Gherig's disease).
Glutamate dysregulation inofungidzirwawo kuti inhengo ye fibromyalgia uye isingagumi kuneta muviri , kunyange zvazvo izvi zvisingaonekwi neurodegenerative.
Glutamate & Fibromyalgia
Kutsvakurudza kunoratidza kuti vanhu vane fibromyalgia vane maitiro akasiyana-siyana e-glutamate munzvimbo yeuropi inonzi insula kana insular cortex. Iyo insula inobatanidzwa mukugadzirisa zvose zvinorwadza uye manzwiro. Iyo yakakwirira ye glutamate inoratidza kuti iyi nzvimbo yeuropi inogona kunge isingagadziriswi mumamiriro ezvinhu aya.
Iyo insula inosanganisirawo mune:
- the senses
- kuzvidya mwoyo
- motokari unyanzvi
- chido
- zvinetso zvekudya
- addiction
Mufibromyalgia, kuwedzera kwekunzwa kungawedzera, zvichiita kuti kuwedzeredza . Kuzvidya mwoyo chiratidzo chinowanzoonekwa / chinoputika. Unyanzvi hwemotokari hungave hwakakundikana, hunoita kuti kuenzanisa matambudziko uye kuwira . Kudya zvinetso zvingave zvakajairika kuvanhu vane fibromyalgia, pamwe chete.
Glutamate iripo munzvimbo dzomuviri kunze kwenheyo yenheyo, iyo inoshanda sehomoni. Mune basa iri, rinogona kukonzera marwadzo.
Chidzidzo che 2016 chinoratidza kuti kurovedza muviri kunogona kuderedza marwadzo anokonzerwa ne glutamate kune vanhu vane fibromyalgia, iyo inogona kubatsira kutsanangura kuwirirana kunonzwisisika pakati pehutano ichi uye kuedza .
Glutamate in Chronic Chronic Fatigue Syndrome
Zvidzidzo zvakaparadzaniswa sekuti glutamate dysregulation inobatanidzwa mukusingaperi kusaneta syndrome, mamiriro ezvinhu anosanganisirawo kushungurudzika, kunyanya, uye kufambisa / kuenzanisa matambudziko .
Kusiyana ne fibromyalgia, zvisinei, zvidzidzo zvinoratidza kuti mazinga e glutamate angave akaderera kune dzimwe nzvimbo dzeuropi. Izvozvo zvinonzwisisika paunofunga nezvehupombwe hwehuropi hunobatanidza nechirwere ichi, chinosanganisira zvinetso nekudzidza.
Isuwo tine humwe uchapupu hunoratidza kuti kusingaperi kuneta kwechirwere kunogona kusanganisira mazamu anoenderana ne glutamate dysregulation.
Monosodium Glutamate
Sezvo amino acid, glutamate inhengo ye monosodium glutamate (MSG), inoshandiswa mune mamwe mishonga uye sekuwedzera kwezvokudya.
Inogona kunge yakabatana nezvimwe utano husina kunaka hunovhiringidza.
Vamwe vashandi veutano vanotenda MSG inogona kukuvadza kuvanhu vane fibromyalgia, asi vamwe vanotenda kuti haisi. Vamwe vanhu vanoti kubvisa MSG kubva pakudya kwavo kwakabatsira kuderedza zviratidzo zve fibromyalgia uye kusingaperi kuneta kwechirwere, asi izvi zvinodaro hazvisimbiswi nesayenzi yezvokurapa.
Glutamate & Other Neurotransmitters
Iwe unogona kunge uri kunetseka kuti uropi hwako hunobata sei nepamusoro ye glutamate. Iine mhinduro-imwe yeurotransmitter inonzi GABA. Basa reGABA nderekudzivisa huropi hwako mushure mekunge glutamate aita zvose zvigadziriswa.
Zvakakosha kuti GABA uye mazinga ekugwinya ave akaenzana kune mumwe nemumwe, asi izvi hazvirevi kuti pane chirwere chinokonzerwa ne glutamate.
Dzimwe nyanzvi dzedzidzo dzakabatanidzwa mumamiriro aya dzinosanganisira:
Hannestad U, Theodorsson E, Evengård B. Nyaya yezvemakirini emakemikari. 2007 Feb; 376 (1-2): 23-9. beta-Alanine uye gamma-aminobutyric acid mumuviri usati wanyanyisa.
Harris RE, et. al. Arthritis uye rheumatism. 2009 Oct; 60 (10): 3146-52. Yakawanda inonzi insular glutamate mu fibromyalgia inobatanidzwa nekurwadziwa kwekuedza.
Kuratsune H, Yamaguti K, Lindh G, et al. NeuroImage. > 2002 Nov; 17 (3): 1256-65. Nzvimbo dzebongo dzakabatanidzwa mukuneta kunzwa: kuderedza acetylcarnitine kupinda muuropi.
> Martins DF, Siteneski A, Ludtke DD, et al. Molecular neurobiology. 2016 Sep 13. [Epub mberi kwekudhinda] High-intensity kushambadzira muviri inoderedza glutamate-induced nociception nekuita g-protein-coupled receptors inhibiting phosphorylated protein kinase a.
Smith AK, Fang H, Whistler T, uye al. Neuropsychobiology. > 2011; 64 (4): 183-94. Kuchinja maitiro ekudzidzira maitiro ekutsvaga kusangana kweGIK2 neNPAS2 ine chirwere chisingaperi chine simba.