Iro Mabasa Avanoita, Matambudziko Api Anogona Kuita
GABA uye glutamate vane maurotransmitter -chemical messengers muuropi yako. Imwe inonyaradza, imwe inokurudzira, uye inofanirwa kuramba ichienzanisa. Saka chii chinoitika kana kuyerwa uku kuri kukandwa?
Imwe tsvakurudzo inoratidza kuti kusaenzana kwezvinhu zviviri izvi zvinogona kuita basa mu fibromyalgia (FMS). Kutsvakurudza hakusi kwakasimba pakubatanidzwa kwavo musingagumi kuneta ( syndrome) ( ME / CFS ), nedzimwe dzidzo dzichidzorera uchapupu hwekunyengera uye vamwe vasingawani chinhu.
Muhuro Hwako
Uropi hwemunhu hwakaoma kunzwisisa. Neurotransmitter imwe neimwe inoita mabasa akasiyana-siyana, uye inobatanidzwa pamwe chete uye neuron yako (masero europi) nenzira yakaoma yatinonyatsonzwisisa.
Kunyange zvakadaro, tinoramba tichidzidza zvakawanda nezvehuropi uye vanotsvakurudza vave vachikwanisa kubatanidza dzimwe nhengo dzemaurotransmitter dzisina kunaka pane dzimwe zvirwere kana zviratidzo. Vakatorawo nzira dzekuchinja neurotransmitter basa uye vanogona kuona izvo chaizvo zvinokonzerwa nehurukuro.
Uropi hunobudirira zvakare, huchishandiswa kamwe neurotransmitter kuumba imwe. Izvo zvinoshanda zvinonzwisisika paunenge uchitaura nezveshutachiona nemabasa akasiyana, akadai seGABA uye glutamate. Serotonin inonyanyozivikanwa uye maratonin pair ndeimwe muenzaniso, sezvinonzi norepinephrine uye dopamine. Zvose zveeurotransmitter dzinotendwa kuti dzinoparadzaniswa mumamiriro aya.
Apo imwe yeurotransmitter muviri isiri yakanyanyisa, inogona kukanda iyo imwe kunze, zvakare.
Glutamate
Glutamate ishamwari ye cheerleader yehuropi hwako. Chimwe chezvinhu zvayo chikuru ndechokuita mamwe masero europi akadzingwa. Zvinokurudzira kuti vaite zvinhu zvakakosha sekudzidza ruzivo rutsva kana kuumba zviyeuchidzo-zvimwe zvinhu izvo glutamate inosanganiswa.
Zvisinei, mutendi anoramba akakuita kuti utaure zvinhu zvinotambudza mushure mechinguva. Zvakawanda zvekukurudzira hachisi chinhu chakanaka, sezvo munhu wese akadhakwa nenzira yakawanda kahawa anogona kukuudza. Mune mamwe mamiriro ezvinhu, glutamate inogona kuva izvo zvinonzi "excitotoxin," zvinoreva kuti dzimwe nguva inowanikwa kune-kudarika neurons kusvikira vazviuraya.
Kukwanisa kukonzera rufu rwemasero europi saka nei glutamate inofungidzirwa kuti inobatanidzwa mune zvimwe zvirwere zvinokonzera uropi dzakadai seAlzheimer's disease uye amyotrophic lateral sclerosis (ALS kana Lou Gehrig's disease). (Cherechedza: FMS naM ME / CFS HAVAKAZI kuti kuora mwoyo.)
MuFMS, tsvakurudzo inoratidza kusinganzwisisiki kwakakwirira kwema glutamate mune chikamu cheuropi chinonzi insula kana insular cortex. Vatsvakurudzi vakaenda vakatarisa imomo nokuti nzvimbo iyo inobatanidzwa zvikuru mukurwadziwa uye nemanzwiro, izvo zvinokosha zvikamu zvechiitiko chacho. Iyo insula inobatanidzwawo mukufungidzira kwemanzwiro, ruzivo rwemotokari, kuzvidya mwoyo, zvinetso zvekudya, uye kusvuta.
Kutsvakurudza kwakave kwakabatanidza marefu e-glutamate ane kuora mwoyo uye kuderera kunzwisisika kwebasa kune vanhu vane chirwere cheshuga cheshuga. (Glutamate inogona kubva pane glucose, iyo inowanzove yakakwirira muvanhu vane chirwere cheshuga.) Chimwe chekudzidza kweFMS kwakaratidza kuti kuderera kwemazinga e glutamate kunogona kuderedza marwadzo.
Kuwedzera kwehupfungwa glutamate kunotendwa kunokonzera zviratidzo zvizhinji, kusanganisira:
- hyperalgesia (kurwadziwa kuwedzera, chinhu chinokosha cheFMS)
- kuzvidya mwoyo
- kusagadzikana
- Zviratidzo zveAADHD, zvakadai sekusakwanisa kutarisa
Mune ME / CFS, vamwe vatsvakurudzi vanofunga kuti glutamate basa rakaderera, zvinoreva kuti uropi huri kuwana kukurudzira zvakakwana. Zvisinei, rutendo urwu harisati rutsigirwa neuchapupu.
Kushaya simba kwegutamate muuropi kunotendwa kunokonzera zviratidzo zvinosanganisira:
- kusuruvara
- matambudziko ematambudziko
- kuora mwoyo mupfungwa
- low energy
GABA
GABA inomirira gamma-amino-n-butyric acid. Uropi hwako hunoshandisa glutamate kuti uite GABA.
Basa guru re GABA nderokudzikisa huropi hwako.
Iko kunobatanidzwawo muhope, zororo, kunyanya kuzvidya mwoyo uye musimba basa.
GABA inotendwa yakadzika kana yakashandiswa zvisina kufanira muFMS. Kusvika ikozvino, kutsvakurudza hakurevi GABA kuderedza mu ME / CFS.
Nemhaka yeGABA uye ukama hwepedyo hwemadzimai, zviratidzo zvehuputi GABA kukwana kunogona kufanana, kana kufambidzana, yeauropi glutamate yakawandisa.
Kuwana Kuenzanisa
Kana iwe uchifungidzira GABA / glutamate dysregulation iri kukonzera zvimwe zvezviratidzo zvako, taura nachiremba wako nezvayo. Kune zvinodhaka, zvinowedzera, uye kuchinja kwezvokudya zvinogona kukubatsira kuti uwane chikero chakanaka. Iwe unogona kutsvaga izvo zvasarudzo pano:
Sources:
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Harris RE, et. al. Arthritis uye rheumatism. 2009 Oct; 60 (10): 3146-52. Yakawanda inonzi insular glutamate mu fibromyalgia inobatanidzwa nekurwadziwa kwekuedza.
Harris RE, et. al. Arthritis uye rheumatism. 2008 Mar; 58 (3): 903-7. Dynamic level ye glutamate mukati me insula inobatanidzwa nekuvandudzika mune marwadzo akawanda munzvimbo ye fibromyalgia.
> Lyoo IK, et. al. Archives of general psychiatry. 2009 Aug; 66 (8): 878-87. Akashandura prefrontal glutamate-glutamine-gamma-aminobutyric asidi uye hukama nehutano hwekugadzirisa hutano nekudzvinyirira zviratidzo zvechirwere chechirwere cheshuga mellitus.
Murrough JW, et. al. NMR mu biomedicine. 2010 Jul; 23 (6): 643-50. Kuwedzera kwemhepo inonzi ventricular lactate muhutano hwekushushikana kweutachiona hunokonzerwa ne1H imaging MRS pa 3.0 T. II: kuenzaniswa nehukuru hwekuora mwoyo.