Rheumatoid arthritis isingaperi, systemic, autoimmune, chirwere chinokonzera arthritis . Hapana chiitiko chimwe chete chinosimbisa kuongororwa kwerheumatoid arthritis. Izvozvo zvakati, rheumatoid factor blood test ndiyo imwe yenzira dzinoshandiswa kuongorora chirwere chacho. Rheumatoid factor yakaratidzwa muma1940s. Mumakore achangobva kupfuura, imwe muedzo inozivikanwa se -anti-CCP test (anti-cyclic citrullinated peptide antibody) yakawanikwa ichibatsira munguva pfupi munguva yechirwere chacho.
The Autoantibodies Associated With Seropositivity
Rheumatoid factor is an autoantibody, kazhinji IgM, iyo inosungira kuFc region ye IgG. Autoantibodies ndiwo mapuroteni anokonzerwa nemasikirwo emasimba , asi anokanganisa maitiro emuviri pachake pane kukanganisa zvinhu zvekunze. Kuvapo kweumwe kana kuti zvose zve autoantibodies, rheumatoid factor, uye anti-CCP, inonzi seropositivity kana seropositive rheumatoid arthritis. Kusavapo kwemaviri autoantibodies munharaunda yeropa kunonzi seronegativity kana seronegative rheumatoid arthritis. Inenge 80% yevarwere vane rheumatoid arthritis vane saropositive ye rheumatoid factor. Inenge 70% yevarwere vane rheumatoid arthritis vane saropositive ye anti-CCP.
Kusiyana Muzvirwere Kuoma
Izvo zvave zvataurwa, zvichibva pane zvidzidzo zvechiremba, kuti varwere vane seropositive rheumatoid arthritis vane hutano hwakanyanya hwehutano uye kuwedzera kwezvirwere, pamwe nehuwandu hwehutachiona kupfuura varwere vane seronegative rheumatoid arthritis.
Zvingaita sokuti varwere vakadaro vanoita sevanoshuva vanoda hutsinye hutsinye, asi iyo maonero inoita seinoita nyore. Muzvokwadi, rutivi rwehutonigativity runogona kutsausa.
Mumwe murwere anonzi seronegative angave ane autoantibodies ayo pakutanga akanga ari pasi pezinga kuti aonekwe.
Chaizvoizvo, chirevo chakanyatsojeka kune icho chingave "chisingazivikanwi kana kuti chisingazivikanwi senopositivity". Ikoko kunogona kuvawo nevamwe autoantibodies mukutamba izvo zvisati zvamboedzwa nguva dzose. Somuenzaniso, kuwedzera kune anti-CCP uye rheumatoid factor, autoantibodies inozivikanwa se-anti-CarP (anti-carbamylated protein) inogona kuvapo makore asati asvika rheumatoid arthritis inowanikwa. Anti-CarP inoratidzika iripo inenge 45% yevarwere vemahaematric arthritis, pamwe chete ne16% yehurumatoid arthritis varwere vasina kunaka ye anti-CCP. Kuvapo kweAn antiCarP kunonzi kufanotaura chirwere chakanyanya chirwere cherheumatoid arthritis. Nokudaro, varwere vemajoni vanogona kunge vane chirwere chetachiona kana chirwere chechirwere chakaoma sevatachiona vasina simba uye vanogona kupindura zvakanaka kune utsinye (semuenzaniso, DMARD kana biologic zvinodhaka ).
Inonzi Seropositivity Inovaka Rheumatoid Arthritis Kugona Here?
Zvinokwanisika kuva nemugumisiro wakaipa werheumatoid factor uye anti-CCP, asi zvichiri kuonekwa kuti ine rheumatoid arthritis. Maererano ne 2010 ACR / EULAR Score-Based Criteria yeRheumatoid Arthritis, zvikamu zvinokwana 6 kubva pa10 zvinopindirana nekuongorora chirwere cherheumatoid arthritis. Kubatana pamwe chete , serologic kuedza, maitiro akaoma reactant, uye nguva yezviratidzo zvose inowanikwa mune iyi chirongwa chechikwata.
Mukutaura, murwere angave akanaka kune rheumatoid factor uye haawanikwe ne rheumatoid arthritis. Mamwe mamiriro ezvinhu angave akanaka kune rheumatoid chinosanganisira:
- Sjogren's syndrome
- Systemic lupus erythematosus
- Scleroderma
- Polymyositis
- Dermatomyositis
- Mixed Connective Tissue Disease
- Zvimwe zvirwere
Anti-CCP zvirwere hazvina kuwanika pane zvakanyanya mune dzimwe zvirwere. Anti-CCP inofungidzirwa zvakajeka kudarika rheumatoid iyo yekuona rheumatoid arthritis.
Sources:
Anti-carbamylated protein (anti-CarP) maitiro anotangira kutanga kwerheumatoid arthritis. Shi J. et al. Annals weRheumatic Diseases. 2014 April; 73 (4): 780-3.
http://www.ncbi.nlm.nih.gov/pubmed/24336334
Anti-CCP antibody test as a diagnostic and prognostic tool in rheumatoid arthritis. Niewold TB et al. QJM. 2007 April; 100 (4): 193-201.
http://www.ncbi.nlm.nih.gov/pubmed/17434910
Rheumatoid Arthritis: RA Seronegative uye Seropositive RA: Yakasiyana Asi Asi Yakasiyana? Ajeganova naHuizinga. Nature Reviews Rheumatology. 11, 8-9 (2015).
http://www.nature.com/nrrheum/journal/v11/n1/full/nrrheum.2014.194.html
Kelley's Textbook yeRheumatology. Chitsauko 69. Etiology uye Pathogenesis yeRheumatoid Arthritis. Gary S. Firestein. Ninth edition.