Mumwe nomumwe anonyanya kushandisa zvinodhaka anoshandisa nzira yakasiyana-siyana yekuita
Pari zvino, iyo chete inowanikwa kurapa kwechiriacia chirwere chisina -gluten . Asi izvozvo zvingave zvichange zvichishandurwa.
Nhamba yevatengesi vezvinodhaka vari kuitisa kuongororwa kwekliniki kuti vaongorore kuchengeteka uye kubudirira kwemaverengi emanzwi emishonga. Mumwe nomumwe ane nzira yakasiyana uye nzira yekuita (MOA). Zvinotarisirwa kuti kuburikidza nekudzivisa chirongwa chechirwere ichi, isu rimwe zuva tinogona kubvisa zvachose chirwere chechiliac kubva murayiro yezvirwere zvisingagoneki .
Pakati pevatatu vanonyanya kuvimbiswa mumushonga wezvinodhaka:
INN-202 (Larazotide Acetate)
Innovate Pharmaceutical's INN-202 (larazotide acetate) mushonga unoshandisa enzyme yakasimba yekudya inoratidzika inogona kukonzera gluten musati maitiro ezvirwere zvemuviri wenyu anogona kuzviita. Migumisiro yeChikamu chechipiri chekuongorora kwechipatara yakanga ichivimbisa uye yakaratidza kuti mishonga iyi yose yakachengeteka uye inonzwisisika. Mishonga iyi yeMoA mbiri inoderedza kuora kwematumbo paunenge uchidzidzira kufamba kwemajini animune mumatumbo.
Kunyange zvazvo INN-202 inogona kuderedza zvikuru zviratidzo zvechirwere chechiliac , hazvigoneki kuti munhu achakwanisa kudya zvakawanda zvisingagumi zve gluten. Zvimwe zvinoremedza kudya zvinenge zvichiri kudiwa.
IU.S. Food and Drug Administration (FDA) yakatsvaga-yakatsvaga mushonga. Phase III kliniki mitsva iri kuitika. Migumisiro yekutongwa inogona kuwanika imwe nguva pakati pekupedzisira kusvika muna 2018
Nexvax2 Vaccine
Nexvax2 ndiyo chete inokonzerwa nemishonga inotarisira kurwisa vanhu vanorwara nechirwere ichi uye kuvabvumira kuti vadzokere kune kudya kwakakwana. Nexvan2 yatotanga kubudirira kupedza chirongwa chekuchengetedzwa kweBase Ib uye iri mukugadzirisa kuenda kune miedzo yakakura yeChikamu II.
Nexvax2 inotungamirirwa neboka rinotanga kubuda remishonga inorapa inotarisira kurapa vanhu vagara vachinetseka nechirwere.
Inobva pamitemo yakafanana neyemhando yezvokudya zvemazuva ano inoshandiswa pakurapa. Saizvozvowo vaccine mienzaniso vari pasi pekuongorora kuti vabate zvinetso zve autoimmune zvakadai se multiple sclerosis, rudzi rwechirwere cheshuga, uye rheumatoid arthritis.
Nexvax2 inogadziriswa nevanhu vane gene (DQ2) inowanikwa mune 90 muzana yevanhu vane chirwere. Sezvo zvakadaro, chirwere chacho hachizoshanda kana iwe usina DQ2,
Kunze kweizvi, mumwe mubvunzo mukuru wevanotsvaga mubvunzo ndeyekuti kwenguva yakareba sei migumisiro yechirwere inogona kuva. Ita yeBase Ib yechirwere inobatanidza kudzokorora, Kunyange zvazvo zviitiko izvozvo zvaive zvichivimbisa (vanhu vakawanda vakakwanisa kupedzisa dambudziko re gluten kupfuura avo vari pa placebo), rinoramba richionekwa kuti rakasimba sei uye rakagadzikana zvinodhaka chaizvoizvo.
Hapana shoko asi apo apo vatsvakurudzi vachabva paZvipiri II / III miedzo yekurapa.
BL-7010
BL-7010 inopa nzira yakasiyana chaizvo yekurapa chirwere ichi. Panzvimbo pokurondedzera matumbo kana kupindurwa kwega, BL-7010 inosungira puroteni ye gluten pachayo uye inodzivisa kukwanisa kwayo kubatwa.
BL-7010 inonzi non-absorptive polymer iyo inokwanisa kuvanza gluten kubva kumadziro enzymes inenge ichida kuiputsa. Nokubudirira izvi, maitiro ezvirwere zvemuviri anenge asingakwanisi kutora mhinduro yekuzvimirira.
Izvo zvinokonzera gluten nemishonga zvingadai zvichidzingwa kubva mumuviri muzvigaro.
Mushure mokunge vaine miedzo yakazara yePekutanga I uye II, vashandi vakatora imwe nzira ndokutanga kukurudzira BL-7010 sekuwedzera kwekudya panzvimbo pemishonga yemishonga. MunaJanuary 2016, kambani yakagamuchirwa izvozvi kubva kuEuropean Union uye ikozvino ichitsvaga kuongororwa kwekliniki yehutano pasi pekugadzirwa kwechikwata chechikwata cheChikamu IIb.
Shoko Rinobva
Kunyange zvazvo ichivimbisa, hazvisati zvava pachena kana chero ipi zvayo yemishonga iyi ichaita kuti ikwanise. Pakupedzisira, chero mupiririri angada kuzadzisa zvivimbiso zvitatu kana achizoonekwa sezvakanaka.
Vaizofanira kushandiswa nyore nyore, kusingagumi, kupa sarudzo dzinogadziriswa, kuratidzirwa zvakanaka, uye, kunyanya zvichida, zvingave zvisingakwanisi.
Saka pane zvakawanda zvakasara kuti zvipindurwe. Asi nekuenderera mberi nekutsvakurudza nekunyatsonzwisisika mune nzira dzechirwere , tinogona kuona munguva iyo isu tisisiri kurarama-gluten-isina.
> Kwakabva:
> Wingjiranirun, M .; Kelly, C .; uye Leffler, D. "Mamiriro Emazuva Ano eCeliac Disease Drug Developers t." American Journal of Gastroenterology. 2016; 111 (6): 779-86.