Genvoya i-tablet-imwe, inogadziriswa-miviri inoshandiswa mumishonga inoshandiswa mukurapwa kweHIV, iyo inoumbwa nemishonga mina yakasiyana-siyana yekurapa majekiseni :
- Elvitegravir , integrase inhibitor
- Cobicistat , ane HIV "booster" zvinodhaka
- Emtricitabine, nucleotide reverse transcriptase inhibitor (NtRTI)
- Tenofovir alafenamide (TAF), imwe NtrTI
Genvoya ndiyo yekutanga kuwedzera mapiritsi kuti ashandise TAF, iyo "yakagadziridzwa" yeTenofovir disoproxil fumarate (TDF) inowanikwa mumishonga Truvada, Atripla , uye Complera.
Sezvo zvakadaro, inogona kuonekwa sekuvandudzwa kweStribild , iyo yakagadziriswa-tablet imwe yakagadzirwa naElvitegravir + cobicistat + emtricitabine + TDF.
TAF inonzi yakakosha kune TDF sezvo ichikwanisa kuburitsa mushonga unoshanda zvakanyatsobudirira kune masero uye pamitambo shoma shoma-zvinoreva kuti kune vashoma kuvaka-mishonga muropa reropa uye mukana wakawandisa wekuita mishonga yakabatana nemishonga toxicities.
(Kunyange zvazvo njodzi yeTDF-yakabatana nehutachiona hwehutano inofungidzirwa yakaderera munyika dzakabudirira, njodzi iyo inowanikwa kuwedzera zvikuru munyika dzichiri kusimukira umo kune huwandu hukuru hwehutachiona huripo husati hwavapo.)
Kurapa Kuratidzwa
Genvoya yakagamuchirwa neU.S. Food and Drug Administration musi waNovember 5, 2015, kuti ishandiswe kune vose vakuru nevana vanopfuura makore gumi nemaviri vasina kumbobvira vaine hutachiona hweHIV uye vanorema kukwana 77 lbs (35 kgs). Inobvumirwawo kune vanhu vakuru parapi iyo yakanyanyisa zvachose (isina kuoneka) utachiona hwehutachiona .
Formulation
Genvoya iplateti yakasvibirira, yakareba, yakafukidzwa nefirimu, ine 150mg ye elvitegravir, 150mg ye cobicistat, 200mg emtricitabine uye 10mg yeTAF. Iyo yakazara ne "GSI" kune rumwe rutivi uye ine "510" pane imwe.
Dosage
Rimwe pfupa rinotorwa zuva nezuva nechingwa. Genvoya haafaniri kutorwa nedzimwe mishonga inorwisa mabhakitiriya inoshandiswa kurapa HIV.
Migumisiro Yechiri
Zvimwe zvinokonzerwa nezvinodhaka zvinonzi zvakaonekwa mukuchipatara chirwere vanotora Genvoya. Zviitiko zvinowanzovhiringidza zvakanyanya, zvakataurwa mu5% kana kupfuura zvevarwere, ndezvi:
- Nausea
- Diarrhea
- Kuneta
- Headache
Zvimwe zvikanganiso zvaiwanzoitika kwenguva pfupi, kugadzirisa pamusoro pemisangano yevhiki mbiri, uye vashoma vashoma vachiregerera semugumisiro wokusashivirira kwekurapa.
Contraindications
Genvoya haafaniri kutorwa nemishonga inotevera kana kuwedzera.
Anti-migraine mishonga: Cafergot, Migergot, Ergostat, Medihaler Ergotamine, Wigraine, Wigrettes, Ergotrate, Methergine, DHE 45
- Anti-psychotic mishonga: Orap
- Cholesterol-kuderedza mitemo yemishonga: Zocor, Simcor, Vytorin, Mevacor, Advicor, Altoprev, Mevacor
- Hepatitis B mishonga: Hepsera, Preveon
- Prokinetic agents: Propulsid, Propulsid Quicksolv
- Mishonga yeprostate: Uroxatral
- Pulmonary hypertension medication: Revatio
- Anti-tuberculosis mishonga: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
- Sedatives: Versed, Halcion
- St. John's Wort
Zvimwe Zvokufungisisa
Genvoya haina kukurudzirwa kune varwere vane kupererwa kwepvo (inotsanangurwa seine kufungidzirwa kwechiremera kubvisa zvisingasviki 30mL neminiti). Ndapota vaudza chiremba wako kana wakambove kana uri kurapwa chero upi noupi hwepfungwa dzepfungwa nedzimwe chiremba.
Genvoya haisi kukurudzirwa kune varwere vane utera hutachiona kana kune avo vane chirwere chepachipatara chepatachipatara B (HBV) chisingagoneki sezvo zvinogona kuwedzera zvakanyanya zvinetso zveropa. Inorayirwa kuti vanhu vane HIV vanongororwa neHBV vasati vasarudza Genvoya. Ndapota wakurudzira chiremba wako kana une dambudziko rechiropa uye / kana nhoroondo yehepatitis.
Sources:
US Food and Drug Administration. "FDA inobvumira kurapwa patsva kweHIV." Silver Spring, Maryland; nyaya yekubudiswa yakabudiswa musi waNovember 5, 2015.
Girasi Sciences. "Genvoya - Pfungwa Dzokunyora Mashoko." Foster City, California