Kusanganiswa kwePiritsi yeHIV pakati pezvinonyanya kutaurwa pasi pose
Kurongwa
Atripla i-single-pill, inogadziriswa muzana pamwe chete (FDC) ine mishonga mitatu inorwisa mahara: tenofovir, emtricitabine uye efavirenz.
Tenofovir uye emtricitabine zvose zvinosanganiswa se nucleotide reverse transcriptase inhibitors uye zvinotengeswa zvakasununguka seViread (tenofovir) , Emtriva (emtricitabine, FTC), uye co-formulated FDC Truvada (tenovfovir + emtricitabine).
Efavirenz, nenzira yakasiyana, haisi nucleoside reverse transcriptase inhibitor uye inoshambadzirwa kutengeswa seSusvava (efavirenz) .
Atripla aibvumirwa neU.S. Food and Drug Administration (FDA) musi waJune 12, 2012 uye waiva wekutanga kamwe-zuva rimwe nerimwe, matatu-mu-umwe chirongwa chakabvumirwa kushandiswa mukurapwa kweHIV kuvanhu vakuru nevana vane makore gumi nemaviri nekure.
Kusvika 2015, Atripla aive akaiswa seanoda, mushonga wekutanga weHIV mune zveUnited States, uye inenge chikamu chetatu chevarwere vose vakagadzirirwa mushonga. Zvitsva zvizvarwa zvinotevera zvinodhaka (izvo zvakazvirumbidza zvishoma nezvishoma uye zvakagadzikana zvakagadzikana) zvakaguma Athukumla kubva kune "yakarongedzwa" mishonga yezvirwere kune "iye zvino" iye zvino mamiriro ekutanga.
Ikozvino hapana maitiro ezve generic kune Atripla muUnited States
Atripla Formulation
Atripla iplate yakaumbwa yakaitwa 300mg tenofovir disoproxil fumarate, 200mg emtricitabine, uye 600mg efavirenz.
Iyo piniki, yakafuridzirwa pfuti yefirimu yakavezwa uye yakaiswa kune rumwe rutivi nenhamba "123."
Atripla Dosage
Kune vanhu vakuru nevana makore gumi nemana kana kupfuura vanorema 87 lbs (40kg): imwe piritsi inotorwa mumuromo kana isina chinhu, panguva chaiyo yokurara (nekuda kwechezheni inogona kubuda nekuda kweefavirenz chikamu).
Kune varwere vanotora rifampin (vanoshandiswa kakawanda mukurapa tuberculosis coinfection) vanoyera inenge 110 lbs (50kg): imwe Atripla tablet uye imwe tablet ye Sustiva (efavirenz) inotorwa nemuromo, zvakare pane isina chinhu mudumbu uye panguva chaiyo yokurara.
Atripla Side Effects
Maitiro akawandisa anowanzobatanidzwa neAtripla kushandiswa (kunoitika munenge ma5% emhosva) kunosanganisira:
- Nausea
- Diarrhea
- Kuneta
- Sinusitis
- Headache
- Chizutu
- Kuora mwoyo
- Kunyunyuta
- Abnormal kurota
- Mapundu
Zvizhinji zvezviratidzo izvi zvinowanzopfupika, zvinowanzogadzirisa pachavo mukati mevhiki kana maviri. Zvimwe zvepakati dzemagetsi zvinokonzera kushungurudzika, sekuzora, dzimwe nguva dzinotora nguva yakareba kuti dzigadzirise, kunyange zvazvo kutora mapiritsi usiku, nguva isati yambovata, kunowedzera kuderedza zviratidzo zvikuru.
Contraindications
- Antifungal mishonga: Vrend (voriconazole)
- Hepatitis B mishonga: Hepsera (adefovir)
- Ergot zvigadzirwa (kusanganisira Wigraine neCafergot)
- Calcium channel blockers: Vascor (bedripil), Propulsid (cisapride), Orap (pimozide)
- St. John's Wort
Kurapa Kufungidzirwa
Varwere vave vakamboona maitiro akare, akasimba ekugadziriswa kwemasimba kuSustiva (kusanganisira kukanganisa kwakanyanya kana kuputika) haafaniri kutarisirwa Atripla.
Atripla inofanira kushandiswa nekuchengetedzwa nevarwere vane nhoroondo yehupombwe (tsitsi) kuora mwoyo.
Nguva dzose rongororei zvakafanirwa kuti muumbi wekusununguka musati watanga kurapwa. Mune varwere vane njodzi yekudzivisa kushaya simba, inosanganisira kuenzaniswa kwema creatinine, serum phosphorus, urini glucose uye urine protein pakatarisa. Atripla haifaniri kushandiswa kune varwere vane inofungidzirwa kuti vumbiki iri pasi pe 50mL / minute.
Chengetedza chiropa chekuita zvirwere muhepatic varwere vane chirwere chepachiropa chiri pasi, kusanganisira hepatitis B uye hepatitis C. Atripla haina kukurudzirwa kune varwere vane uwandu hwehutachiona hwehutachiona husina kunaka. Shandisa nekuchenjerera kune varwere vane utachiona husina kuchena.
Efavirenz chikamu muAtripla chave chichibatanidza nehutachiona husina kunaka mukudzidza kwezvipfuwo zvakawanda.
Nepo pachinenge kuine kukakavara pamusoro pekuti kana efavirenz inokonzera chero njodzi chaiyo muvanhu, zvinokurudzirwa Atripla kudzivirirwa panguva yekuzvimba), kunyanya munguva yekutanga chemutatu. Amai vanorayirwawo kuti vasazamwa panguva yekutora Atripla.
Atripla inofanira kurongerwa nekuchenjerera kune vanhu vane matambudziko, pamwe chete nevaya vane schizophrenia, kliniki yekuora mwoyo, kana zvimwe zvirwere zvepfungwa. Efavirenz chikamu chinozivikanwa kuti chinokanganisa nheyo yepamusoro yenheyo, zvichiita kuti uve nechezuru, zviratidzo zvakajeka, unsteadiness, nekunyangadza mune vamwe vanhu.
Sources:
US Food and Drug Administration (FDA). "FDA Inobvumira Chekutanga Chekuita-Rimwe-Zuva, Matatu Mishonga Yokurapa kweHIV-1." Silver Spring, Maryland; gwaro rehurukuro rakabudiswa naAugust 2, 2004.
Bristol Myers Squibb. " Pfungwa Dzokunyora Mashoko - ATRIPLA ." 2006.