Truvada i-single-pill, inogadziriswa miviri inosanganiswa nemishonga inosanganisira maviri antiretroviral agents, tenofovir uye emtricitabine, zvose zvinorondedzerwa se nucleotide reverse transcriptase inhibitors. Izvo zvikamu zviviri zvezvinodhaka zvinotengeswa zvakasununguka seViread (tenofovir) uye Emtriva (emtricitabine, FTC).
Truvada yakabvumirwa neU.S. Food and Drug Administration (FDA) munaAgasti 2004 kuti ishandiswe mukurapwa kweHIV , kunyanya vanhu vakuru nevana vanopfuura makore gumi nemaviri vanoyera mapaundi 77 (35kg) kana kupfuura.
Truvada akazopiwa mvumo yeDPA munaJuly 2012 kuti ishandiswe mukudzivirira kuwanikwa kweHIV kune vanhu vane ngozi zvikuru mune imwe nzira inonzi pre-exposure prophylaxis (PrEP) .
Formulation
A tablet-formulated tablet yaive ne 300mg tenofovir diisopropyl fumarate uye 200mg emtricitabine. Girafu yebhuruu, yakavharidzirwa yakafuridzirwa yakaitwa nefirimu uye yakavezwa kune rumwe rutivi nenhamba "701" uye imwe ine zita rinogadzira "GILEAD."
Dosage
- Kune varwere vane HIV: imwe piritsi zuva rega rega, inotorwa nemuromo kana kuti isina zvokudya.
- Kushandisa sePPREP: bheti rimwechete zuva rega rega, rinotorwa nemuromo kana kuti risina kudya.
- Kune varwere vane renal (kidzo) kuora mwoyo: imwe piritsi inotorwa maawa makumi maviri nemashanu kana chikamu chekusika chiri pakati pe 30-49mL / miniti. Kana iri pasi pe30mL / miniti kana pa hemodialysis, usashandise .
Mirayiridzo
Kune varwere vane HIV, Truvada inofanira kutorwa pamwe chete nemishonga inorwisa ma antiretroviral agents.
Apo inoshandiswa sePrEP, Truvada inotorwa seyo sechikamu chakakwana chekudzivirira hutachiona hweHIV, iyo inosanganisira makondomu nemimwe nzira dzakachengeteka dzepabonde.
Nharaunda Dzakabatana
Matambudziko anowanzobatanidzwa neTruvada anoshandiswa (anowanikwa mu5% kana kuti maduku ematambudziko) anosanganisira:
- Nausea
- Diarrhea
- Kuneta
- Sinusitis
- Headache
- Chizutu
- Kuora mwoyo
- Mapundu
Contraindications
Sezvo mutemo, chero chirongwa chakatarwa chinosanganiswa nemishonga ine tenofovir, emtricitabine kana lamivudine (imwe nhengo yeNRTI yakafanana neyomtricitabine) haifaniri kutorwa neTruvada.
- VHIV antiretroviral drugs: Atripla (tenofovir + emtricitabine + efavirenz), Combivir (Retrovir + lamivudine), Complera (tenofovir + emtricitabine + rilpivirine), Emtriva (emtricitabine, FTC), Epivir (lamivudine, 3TC), Epzicom (abacavir + lamivudine) , Stribild (tenofovir + emtricitabine + elvitegravir + cobicistat), Triumeq (abacavir + lamivudine + dolutegravir), Trizivir (Retrovir + abacavir + lamivudine), Viread (tenofovir)
- Hepatitis B mishonga: Hepsera (adefovir)
Kuwirirana
Kudza chiremba wako kana iwe uri kutora chimwe cheizvi:
- Anticoagulants: Lixiana (edoxaban), Pradaxa (dabigatran)
- Zvisiri-maduku-masero emukenza wemapapu emapapu: Ofev / Vargatef (nintedanib)
Kurapa Kufungidzirwa
Truvada inofanira kushandiswa nekuchengetedzwa nevarwere vane nhoroondo yehupombwe (yeputsvo) kuora mwoyo. Nguva dzose rongororei zvakafanirwa kuti muumbi wekusununguka musati watanga kurapwa. Mune varwere vane njodzi yekudzivisa kushaya simba, inosanganisira kuenzaniswa kwema creatinine, serum phosphorus, urini glucose uye urine protein pakatarisa.
Kuchengetedza kunofanira kutorwa kana kubatanidzwa Truvada neAIDS antiretroviral drug Videx (didanosine). Kunyange zvazvo nzira dzekubatana dzisingazikamwi, zvidzidzo zvakaratidza kuti co-administration inogona kukura majekiti eSirium uye kuwedzera mikana yezviitiko zvakashata (semuenzaniso, pancreatic, neuropathy).
Zvinokurudzirwa kuti Videx yakaderedzwa kusvika 250mg kune varwere vanoyera makirogiramu makumi matanhatu (60kg) kana kupfuura.
Dhaka inowanika yevanhu uye yemhuka inoratidza kuti Truvada haina kuwedzera njodzi yekuremererwa kwepamuviri panguva yekuzvitakura . Zvisinei, nokuti migumisiro ye tenofovir uye emtricitabine pamucheche haisati yazivikanwa, vanaamai vanokurudzirwa kuti vasamwisa kana vakatora Truvada.
Sources:
US Food and Drug Administration (FDA). "FDA Inobvumira Zvimwe Zvinokonzerwa-Dose Mikana Drug Products For Treatment of HIV-1 Infection." Silver Spring, Maryland; gwaro rehurukuro rakabudiswa naAugust 2, 2004.
FDA. "FDA inobvumira mushonga wekutanga kutanga kuderedza dambudziko rekuwana HIV." Silver Spring, Maryland; nyaya yekubudiswa yakabudiswa musi waJuly 16, 2012.