Kukosha Kwezvinodhaka Kunyora Mashoko
Stribild (inozivikanwawo seyakadzama seQead pill) iyo-tablet-imwe, inogadziriswa-miviri inosanganiswa nemishonga inoumbwa neine ma antiretroviral anoshandiswa pakurapa HIV:
- tenofovir , nucleotide reverse transcriptase inhibitor
- emtricitabine, yechipiri nucleotide reverse transcriptase inhibitor
- elvitegravir , integrase inhibitor
- cobicistat , ane hutachiona hweHIV
Stribild yakagamuchirwa neU.S. Food and Drug Administration (FDA) munaAgasti 2012 kuti ishandiswe kune vanhu vakuru 18 uye kupfuura avo vari kutanga ma antiretrovirals kwekutanga, kana kune avo vane utachiona hweHIV avo vakanyatsoparadza (zvisingaoneki) mishonga yehutachiona .
Kuchengetedzwa nekubudirira kweStribild zvakarongedzwa muna 1 408 varwere vasati vashandurwa vakura mumakirini emakiriniki maviri, avo vakatsanangura kuti Stribild yakanga yakagadzikana uye yakanyatsorambidzwa seAtripla , imwezve yakagadzirirwa kutonga madhiragi yakaitwa tenofovir, emtricitabine, uye efavirenz .
Muna 2016, kuumbwa kwechirwere chitsva chinonzi Genvoya chaiva nechibvumirano neRDA, kutora tenofovir nechinangwa chitsva chechirwere chinonzi tenofovir alafenamide (TAF), iyo inozivikanwa kuva nemigumisiro shomanana uye inodhaka mishonga inodhaka.
Formulation
Stribild isheti, yakareba, yakafuridzirwa nefirimu, ine 150mg ye elvitegravir, 150mg ye cobicistat, 200mg emtricitabine uye 300mg tenofovir. Iyo yakafukidzwa ne "GSI" kune rumwe rutivi uye ine "1" iri mune chikamu pane imwe.
Dosage
Rimwe piritsi rimwe nerimwe rinotorwa nechingwa. Stribild haafaniri kutorwa nedzimwe mishonga inoshandiswa kurwisa HIV.
Migumisiro Yechiri
Mamwe madhiragi emigumisiro akave akaonekwa muvarwere vanotora Stribild. Zviitiko zvinowanzovhiringidza zvakanyanya, zvakataurwa muna 7% kana kupfuura varwere, vaiva:
- Nausea
- Diarrhea
- Headache
- Abnormal kurota
Kubatana kwezvinodhaka kana kusawirirana
Stribild haafaniri kutorwa nemishonga inotevera kana kuwedzera.
- Anti-migraine mishonga: Cafergot, Migergot, Ergostat, Medihaler Ergotamine, Wigraine, Wigrettes, Ergotrate, Methergine, DHE 45
- Anti-psychotic mishonga: Orap
- Cholesterol-kuderedza mitemo yemishonga: Zocor, Simcor, Vytorin, Mevacor, Advicor, Altoprev, Mevacor
- Hepatitis B mishonga: Hepsera, Preveon
- Prokinetic agents: Propulsid, Propulsid Quicksolv
- Mishonga yeprostate: Uroxatral
- Pulmonary hypertension medication: Revatio
- Rifampin-based anti-tuberculosis mishonga: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
- Sedatives: Versed, Halcion
- St. John's Wort
Kufunga
Stribild inogona kuva yakaoma kuvanhu vane nhoroondo yezvinetso zvepso. Ndapota vaudza chiremba wako iwe une nyaya dzakadaro usati watora Stribild. Iropi basa rinofanira kugara richiedzwa muvarwere veStanri. Rega kurapwa kune varwere vane inofungidzirwa kuti vumbiki yakasununguka pasi pe 50mL / miniti. Nehrotoxic zvinodhaka hazvifanirwe kutungamirirwa ne Stribild.
Zviviri zvezvinoshandiswa zvinoshandiswa muStribild (tenofovir, emtricitabine) zvinoshandawo nehutachiona hweHpatitis B (HBV) . Kana uine HBV uye urega kutora Stribild, iwe uchafanira kutarisa mavhenekeri emuropa kwemwedzi inoverengeka sezvo kumira dzimwe nguva kunogona kuita kuti HBV iparadze.
Sezvakakonzerwa nemarara ose ekutanga pamwe nemishonga inorwisa mabhakitiriya, iyo NRTIs muStribild inobatanidza nehutano hushoma hwe lactic acidosis, uyewo nezvinetso zveropa.
Kana uri kutarisana nekufema kwemhepo; kushungurudza uye kurutsa; kurwadziwa kana kusatarisirwa kwemuviri kusagadzikana; kunyengera uye kuneta; kushaya simba mumaoko nemaoko; kana kuchena kweganda uye / kana meso, dana chiremba wako pakarepo. Lactic acidosis, kunyanya, inogona kunge inouraya kana isina kusiyiwa.
Sources:
US Food and Drug Administration. "FDA inobvumira piritsi itsva yekubatanidza kurapa HIV kune vamwe varwere." Silver Spring, Maryland; gwaro rehurukuro rakabudiswa musi waAugust 27, 2012.
Wohl, D .; Cohen, C .; Gallant, J .; et al. "Elvitegravir / cobicistat / emtricitabine / tenofovir DF (STB) ine simba rakasimba uye rakasiyana nekuchengetedza kwenguva refu uye kushivirira kune efavirenz / emtricitabine / tenofovir DF (ATR) pavhiki 144 mune varwere vasina HIV vane HIV." 53rd Interscience Conference pamusoro peAntimicrobial Agents uye Chemotherapy (ICAAC). Denver, Colorado, September 11, 1013; abstract H-672a.
Shalit, P .; Gallant, J .; Zvipfeko, A .; et al. "Kugara kwenguva refu kweElvitegravir / cobicistat / emtricitabine / tenofovir DF kuenzaniswa ne efavirenz / emtricitabine / tenofovir DF kana ritonavir-yakasimbiswa atazanavir pamwe emtricitabine / tenofovir DF mumatachiona asina HIV ane HIV. 53rd Interscience Conference pamusoro peAntimicrobial Agents uye Chemotherapy (ICAAC). Denver, Colorado; September 11, 2013; abstract H-671.