Urongwa:
Tybost (cobicistat) chirwere chinorondedzerwa seCYP3A inhibitor inoshandiswa pakurapa HIV . Tybost inoshanda ne "kukurudzira" majekiseni eparamma emishonga inorwisa mabhakitiriya, Vitekta (elvitegravir), Reyataz (atazanavir) uye Prezista (darunavir) , iyo inoshandiswa mukubatanidza antiretroviral therapy (kadhi) .
Tybost chikamu chezvikamu zvitatu zvakagadziriswa kuenzanisa mishonga, Stribild (elvitegravir + cobicistat + tenofovir + emtricitabine) , Evotaz (atanazavir + cobicistat) uye Prezcobix (darunavir + cobicistat) ,
Tybost yakabvumirwa neU.S. Food and Drug Administration (FDA) munaSeptember 2014 kune vose vane ruzivo uye vachangobva kuongororwa vane varwere vane HIV-1.
Fomu:
150mg piritsi-yakavharidzirwa piritsi yeplate, chiedza chine ruvara rwemaruva muvara uye yakaiswa mazita "GSI" kune rumwe rutivi.
Dosage:
Imwe 150mg tablet yakatorwa zuva nezuva nechingwa panguva imwe chete seReyataz kana Prezista. Therapy inofanira kusanganisira imwe kana yakawanda, inosangana nemishonga inotapukisa antiretroviral (s).
Mirayiridzo:
Usati watanga, varwere vanofanira kuongororwa kuti vaongorore maonero avo ekufungidzirwa kwechiremera sezvo Tybost inogona kukanganisa kusanganisa (mafungiro) basa, kazhinji mune varwere vanozivikanwa kana vasingazivikanwi kushandiswa kwechirwere chisingaiti. Kana ichitungamirirwa neViread (tenofovir) -chirwere chinonziwo chinokonzera kukanganisa kwechirwere kune vamwe-zvinokurudzirwa kuti varwere vaongororwe kugadziriswa kwechirongwa chekusika, urini glucose uye mapuroteni emuti.
Matambudziko akafanana:
Muchikamu chechitatu III zvidzidzo zvekuchirapa, huwandu hunogona kuve nemigumisiro yemishonga yakagadziriswa pakushandisa Tybost.
Zviitiko zvinowanzovhiringidza zvakanyanya, zvakataurwa mu 2% kana pasi pevarwere, vaiva:
- Jaundice (kuchena kweganda nemeso)
- Ocular icterus (kupenya kwemaziso)
- Nausea
- Diarrhea
Zvisingabatsiri zvinokanganisa zvinosanganisira kuneta, kuora musoro, kusuruvara, kurutsa uye kurwadziwa kwepamuviri. Iroyi mabwe akaonekwawo mune vamwe varwere apo Tybost aitungamirirwa naReyataz uye Viread, kunyange zvazvo mhosva dzacho dzaionekwa sedzakanaka uye hadzina kubvisa kurapwa kwekurapa.
Kusiyana kwezvinodhaka:
Tybost haafaniri kutorwa nemishonga inotevera kana mishonga inowedzera:
- Anti-arrhythmic mishonga: Multaq
- Anti-cholesterol mishonga: Mevacor, Zocor
- Anti-gout mishonga: Uroxatral
- Anti-hypertension medication: Revatio
- Anti-psychotic mishonga: Orap
- Kanzira mishonga: Camptosar, Campto (apo inotungamirirwa naReyataz)
- Ergot-ine anti-migraine zvigadzirwa: DHE 45, Ergotrate, Hydergine, Migrana
- Rifampin-based anti-tuberculosis mishonga: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
- Sedatives: Dormicum, Halcion, Hypam, Hyponvel, Trilam, Versed
- St. John's Wort
Antiretroviral Drug Interactions:
Kushandiswa kweTybost nekutevera ma antiretroviral mishonga kunogona kukonzera kana mukurasikirwa kwekurapa kwechirwere ichi pamwe chete kana kuwedzerwa kwemigumisiro:
- Crixivan (indinavir) haafaniri kutungamirirwa naTibost naReyataz.
- Intelence (etravirine) haifaniri kutungamirirwa neTybost.
- Sustiva (efavirenz) haafaniri kutungamirirwa neTybost uye Prezista.
- Viramune (nevirapine) haifaniri kutungamirirwa naTybost uye Prezista.
- Selzentry (maraviroc) inoshandiswa inofanira kuchinjwa kusvika 150mg kaviri zuva rimwe nerimwe kana ichishandiswa pamwe neTybost.
Zvimwe Kuwirirana kana Kufungisisa:
- Taurira chiremba wako chero ipi zvayo inozivikanwa kana kuti inenge yafungidzirwa yehupi iwe ungave nayo usati watanga Tybost.
- Antacids ane aluminium kana magnesium hydroxide inogona kudzivirira Tybost / Reyataz kuti iite zvakanaka. Kana iwe uri kushandisa ye-anti-antacid (eg Rolaids, Tums, Milk yeMagnesia), inoratidzirwa kuti inotorwa maawa maviri asati apfuura kana mushure mutezo weTybost / Reyataz.
- H 2- vasingagamuchirwi vanopesana vanoshandiswa kudzivirira dumbu asidi (seg., Tagamet, Pepcid, Axid, Zantac) inogonawo kudzivirira kuwedzerwa kweTybost / Reyataz. Inoratidzirwa kuti inotorwa pamwe naTybost / Reyataz kana, pamwe chete, 10 awa mushure mokunge kana mushure mutezo weTybost / Reyataz.
- Proton pump inhibitors (p., Losec, Prilosec, Prevacid, Nexium, Pariet) inogonawo kubvisa kunyanya kweTybost / Reyataz. Inoratidzirwa kuti inotorwa kana maawa gumi nemaviri asati apfuura kana mushure mutezo weTybost / Reyataz.
- Erectile dysfunction medication (Viagra, Levitra, Cialis) inofanira kushandiswa nekuchenjerera sezvo Tybost inogona kusimbisa huwandu hwemigumisiro yakaipa, kusanganisira kuvhiringidzika kunoonekwa, hypotension, uye priapism (zvinorwadza, zvakasimbiswa erections). Zvinokurudzirwa kuti Viagra muyero iwedzere kusvika kudarika 25mg mumaawa 48; Murairo weLevitra unoderedzwa kusvika pakupfuura ma 2.5mg mumaawa 72; uye mizizi yeCialis iri kuderera kusvika kudarika 10mg mumaawa 72.
Sources:
Girasi Sciences. "Tybost (cobicistat) - FULL PRESCRIBING INFORMATION." Foster City, California; yakasvika musi waFebruary 3, 2015.