Fixed Dose Zvinokonzerwa Nezvinodhaka Zvinopa Imwe-Zuva Nezuva, Kurapa Kwepiritsi Rimwechete
Kurongwa
Complera i-tablet imwe chete, yakagadziriswa inosanganiswa inoshandiswa mushonga weHIV, iyo inosanganisira zvitatu zvakasiyana-siyana zvinorwisa ma antiretroviral agents :
- rilpivirine , kwete nucleoside reverse transcriptase inhibitor (NNRTI)
- emtricitabine, nucleotide reverse transcriptase inhibitor (NtRTI)
- tenofovir disoproxil fumarate (TDF), imwe NtrTI
Complera yakagamuchirwa neU.S. Food and Drug Administration (FDA) musi waAugust 10, 2011 kuti ishandiswe kune vose vakuru nevana vanopfuura makore gumi nemaviri vasina kumbove vane chirwere cheHIV , vane utachiona hwemamiriyoni e100 000 / m kana pasi , uye kuyera mapaundi 77 (35kg) kana kupfuura.
Complera inogonawo kushandiswa kutora mushonga wezvino kana murwere ane chirwere chisingaoneki chetachiona (
Formulation
Complera ipeplate, yakagadzirwa nemapapule, yakafukidzwa nefirimu, yakazara 25mg ye rilpivirine, 200mg emtricitabine uye 300mg yeTDF. Iyo yakazara ne "GSI" kune rumwe rutivi uye yakajeka pane imwe.
Dosage
Rimwe piritsi rimwe nerimwe rinotorwa nechingwa. Complera haifaniri kutorwa nedzimwe mishonga inoshandiswa kurwisa HIV.
Migumisiro Yechiri
Zvimwe zvinokonzerwa nemishonga zvinonzi zvakaonekwa mukuchiremba kutongwa varwere vanotora Complera, iyo yakawanda kwazvo iyo yaiva:
- Nausea
- Headache
- Kunyunyuta
- Kuora mwoyo
Zvimwe zvikanganiso zvaiwanzoitika kwenguva refu, uye varwere vashomanana vanoramba vachiguma nekuda kwekusagadzikana kwehutano.
Contraindications
Complera haifaniri kutorwa nemishonga inotevera kana kuwedzera.
- Anti-convulsive mishonga: Tegretol, Trilepta, phenobarbital, phenytoin
- Anti-tuberculosis mishonga: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
- Proton pump inhibitors (PPIs): Nexium, Kapidex, Dexilant, Prevacid, Losec, Prilosec, Protonix, Aciphex kana chero imwe PPI
- Steroid mishonga: dexamethasone (kunyange zvazvo inogona kuendeswa mumushonga mumwechete kana inoratidzwa nemishonga)
- St. John's Wort
Nguva dzose udza chiremba wako chero mishonga chero ipi zvayo kana kuwedzera, yakatemwa kana isiri yakatemwa, kuti iwe unogona kutora usati watanga chero chirwere chetachiona chetachiona.
Zvimwe Zvokufungisisa
Complera haigamuchirwi kune varwere vane kupererwa kwepvo (inotsanangurwa seine kufungidzirwa kwechiremera chechidiki pasi pe 30mL paminiti). Ndapota vaudza chiremba wako kana wakambove kana uri kurapwa chero upi noupi hwepfungwa dzepfungwa nedzimwe chiremba.
Complera haina kukurudzirwa kune varwere vane utera hutachiona kana kune avo vane chirwere chepachirwere chehepatitis B (HBV) chisingagumi sezvo chinogona kuwedzera zvakanyanya zvinetso zveropa. Inorayirwa kuti vanhu vane HIV vanoongororwa neHBV vasati vasarudza Complera. Ndapota udzai chiremba wenyu kana mune dambudziko rechiropa uye / kana nhoroondo yehepatitis.
I rilpivirine chikamu cheComplera chinogona kukonzera kugadziriswa kwehutano mune nhamba shomanana yevarwere, kazhinji nenzira yekutsvaira, kuvhara kweziso ("pink eye"), kuputika kwemaziso, fivha, kana zvimwe zvinogadziriswa. Kazhinji, kugadziriswa kwe hypersensitivity kune mavhiki 1-6 pashure pokutanga kwerapi. Kudza chiremba wako pakarepo chero zviratidzo zvakadaro zvinowanikwa. Mune zviitiko zvakakomba, kurapwa kuchada kubviswa.
Treatment Update
Kugadziriswa patsva kweComplera kwakagamuchirwa neDFA musi waMarch 1, 2016, inotengeswa pasi pezita rokuti Odefsey . Izvo zvinyorwa zvitsva zvinotsiva TDF chikamu nemishonga inonzi tenofovir alafenamide (TAF), iyo yekupedzisira iyo inorondedzerwa sepro-drug.
Kusiyana neTDF, TAF haina mishonga inoshandiswa asi asi inoshandisa muviri wega metabolism kuti igadzire iyo kuva maitiro ayo. Sezvo zvakadaro, mushonga uyu unowanikwa zvakanyanya kune masero ari pamatokisi akare, uye pamwe nechepamusoro kwezvinodhaka zvekushandisa zvinodhaka (zvikurukuru maererano nehutachiona hwehutano hunobatanidza neTDF kushandiswa).
Sources:
US Food and Drug Administration (FDA_. "Kugamuchirwa kweComplera: emtricitabine / rilpivirine / tenofovir DF yakagadziriswa kuwanda kwemazana." Silver Srping, Maryland; yakabudiswa naAugust 10, 2011.
Girasi Sciences. "Complera - Pfungwa Dzokunyora Mashoko." Foster City, California; yakasvika musi waMarch 18, 2016.
Reuters. "KUKUNDA - Sciences Giriyedhi Inoti US FDA Inobvumira Odefsey" Yakabudiswa musi waMarch 1, 2015.