Kusanganiswa Kwakawedzerwa Mishonga Inopa Mikana Miviri Yakaoma
Kurongwa
Odefsey ibheti- rimwe chete, rinogadziriswa doro rinosanganiswa nemishonga inoshandiswa mukurapwa kweHIV, iyo inosanganisira zvitatu zvakasiyana-siyana zvinorwisa ma antiretroviral :
- rilpivirine , kwete nucleoside reverse transcriptase inhibitor (NNRTI)
- emtricitabine, nucleotide reverse transcriptase inhibitor (NtRTI)
- tenofovir alafenamide (TAF) , imwe NtrTI
Odefsey ndiyo yechipiri inosanganiswa nemishonga yekushandisa TAF, iyo "yakagadziriswa" yeTenofovir disoproxil fumarate (TDF) inowanikwa mumishonga Truvada naAtripla .
Sezvo zvakadaro, inogona kuonekwa sekuvandudzwa kweComplera, iyo yakagadzirirwa-tablet imwe yakagadzirwa rilpivirine + emtricitabine + TDF.
TAF inonzi yakakosha kune TDF sezvo ichikwanisa kuburitsa mushonga unoshanda zvakanyatsobudirira kumasero uye pamatokisi maduku-kureva kuti pane kuwedzera kuwedzerwa kwechirwere muropa uye pasina mikana yakawanda yekuita zvinodhaka zvinokonzerwa nemishonga.
(Kunyange zvazvo njodzi yeTDF-yakabatana nehutachiona hwehutano inofungidzirwa yakaderera munyika dzakabudirira, njodzi iyo inowanikwa kuwedzera zvikuru munyika dzichiri kusimukira umo kune huwandu hukuru hwehutachiona huripo husati hwavapo.)
Kurapa Kuratidzwa
Odefsey yakagamuchirwa neU.S. Food and Drug Administration musi waMarch 1, 2016 kuti ishandiswe kune vose vakuru nevana vanopfuura makore gumi nemaviri vasina kumbove vane hutachiona hweHIV , vane utachiona hwemamiriyoni e100 000 / m kana pasi, uye vanoyera 77 pounds (35kg) kana kupfuura.
Odefsey inogonawo kushandiswa kutora mushonga wemazuva ano (zvakadai seaya ari paComplera) kana murwere ave ane utachiona husingaoneki (<50 masero / mL) kwemwedzi mitanhatu, haana nhoroondo yekurapa kurapa, uye haazivikanwe kurwisa chero ipi zvayo yemishonga inowanikwa muOdefsey.
Formulation
Odefsey igwefu, yakafuridzirwa, ipirati yakafukidzwa nefirimu, ine 25mg ye rilpivirine, 200mg emtricitabine uye 25 mg yeTAF.
Iyo yakazara ne "GSI" kune rumwe rutivi uye ine "255" pane imwe.
Dosage
Rimwe piritsi rimwe nerimwe rinotorwa nechingwa. Odefsey haafaniri kutorwa nedzimwe mishonga inoshandiswa kurwisa HIV.
Migumisiro Yechiri
Zvimwe zvinokonzerwa nezvinodhaka zvinonzi zvakaonekwa mumakiriniki kuedza varwere vachitora rilpivirine uye / kana emtricitabine + TAF, iyo yakawanda kupfuura iyo yaiva:
- Nausea
- Headache
- Kunyunyuta
- Kuora mwoyo
Zvimwe zvikanganiso zvaiwanzoitika kwenguva refu, uye varwere vashomanana vanoramba vachiguma nekuda kwekusagadzikana kwehutano.
Contraindications
Odefsey haafaniri kutorwa nemishonga inotevera kana kuwedzera:
- Anti-convulsive mishonga: Tegretol, Trilepta, phenobarbital, phenytoin
- Anti-tuberculosis mishonga: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
- Proton pump inhibitors (PPIs): Nexium, Kapidex, Dexilant, Prevacid, Losec, Prilosec, Protonix, Aciphex kana chero imwe PPI
- Steroid mishonga: dexamethasone (kunyange inogona kutarisirwa mune imwe nhamba, kana inoratidzwa nemuviri)
- St. John's Wort
Nguva dzose udza chiremba wako chero mishonga chero ipi zvayo kana kuwedzera, yakatemwa kana isiri yakatemwa, kuti iwe unogona kutora usati watanga chero chirwere chetachiona chetachiona.
Zvimwe Zvokufungisisa
Odefsey haigamuchirwi kune varwere vane kupererwa kwepvo (inotsanangurwa seine chikwata chakafungidzirwa kuti vusiki yakasununguka inopfuura 30mL paminiti).
Ndapota vaudza chiremba wako kana wakambove kana uri kurapwa chero upi noupi hwepfungwa dzepfungwa nedzimwe chiremba.
Odefsey haigamuchirwi kune varwere vane utachiona husina kunaka kana kune avo vane chirwere chepachirwere chehepatitis B (HBV) chisingagumi sezvo zvinogona kuwedzera zvakanyanya zvinetso zveropa. Inorayirwa kuti vanhu vane HIV vanongororwa neHBV vasati vasarudza Odefsey. Ndapota wakurudzira chiremba wako kana iwe une dambudziko rechiropa uye / kana nhoroondo yehepatitis.
Iyo rilpivirine chikamu cheOdefsy chinogona kukonzera hypersensitivity reaction mune nhamba shomanana yevarwere, kazhinji nenzira yokutsvaira, kuvhara kweziso ("pink eye"), kuputika kwepiso, fivha, kana zvimwe zvinokonzerwa nemagetsi.
Kazhinji, kugadziriswa kwe hypersensitivity kune mavhiki 1-6 pashure pokutanga kwerapi. Kudza chiremba wako pakarepo chero zviratidzo zvakadaro zvinowanikwa. Mune zviitiko zvakakomba, kurapwa kuchada kubviswa.
Sources:
Reuters. "KUKUNDA - Sciences Giriyedhi Inoti US FDA Inobvumira Odefsey." Yakabudiswa musi waMarch 1, 2015.
Girasi Sciences. " Odefsey - Pfungwa Dzokunyora Mashoko." Foster City, California; yakasvika musi waMarch 18, 2016.