Vanotsvakurudza Vanoda kuti "Kika" HIV iri kunze kwekuviga nzvimbo
Nzvimbo dzemazuva ano masero emumuviri umo HIV inokwanisa kuvanza (kana kuti "kuramba") kunyange pasinei nehutachiona hwehutachiona hwehutachiona . Aya mabhazi emagetsi anowanikwa munzvimbo dzakawanda dzesangano, kusanganisira ubongo, lymphoid tissue, marrow bone uye marital genct.
Munharaunda yaro yakaderera (kana kuti "proviral" ), HIV inogona kubatanidza maitiro ayo emarita muDNA yemujeri, asi pane kuuraya iyo, inongorondedzera pamwe chete nemukuru.
Kusiyana nehutachiona husina rusununguko, zviratidzo izvi zvakavanzika hazvigone kuonekwa nemusununguko wemuviri wemuviri. Panzvimbo pacho, utachiona hwehutachiona hunotorwa kubva kune rimwe chizvarwa kusvika kune rimwe chizvarwa, unokwanisa kugadzirisa zvakare kana zvichikonzerwa nekuwa kwekudzivirira muviri.
Iko, chaizvoizvo, maitiro emuviri wemuviri anopa HIV inowanikwa mumagetsi. Apo mhinduro yekuzvidzivirira pamuviri inoshandiswa muhupo hweHIV, muviri unobereka CD4 T-cells iyo, zvinoshamisa, ndiyo inonyanya kutarirwa nehutachiona. Masero akatova nehutachiona hweHIV achawedzera, achiita mamwe masero anotapukirwa neHIV uye anowedzera dutu revirari.
Ndiko kushivirira kwemavhaya aya akavanzwa anoramba achikonzera kuedza kwekurapa mushonga wechirwere.
Nzira dzekugadzirisa Dzimba dzekupedzisira dzeLatent
Dambudziko guru rinotarisana nevatsvakurudzi mazuva ano kuwana nzira dzekugadzirisa nekudzivirira HIV kubva munzvimbo dzayo dzechivako, zvichiita kuti dzive pachena kune dzimwe nhamba dzedzimwe nzira dzekuparadza zvachose .
Apo ART inokwanisa kukonzera matanda aya munguva yakareba, inoita zvishoma nezvishoma. Mathematical models vakaratidza kuti zvingatora makore makumi matanhatu kusvika makumi mapfumbamwe nemakumi matanhatu ekupedzisa kupedza zvachose.
Zvinowedzera, vatsvakurudzi vari kutarisa mukushandiswa kwemimwe mishonga inoita seyokukurudzira kushandiswa kweHIV yakatadza.
Pakati pavo kune avo vanoshevedzwa HDAC inhibitors, izvo zvakagara zvichishandiswa semafungiro emagariro uye anopesana nemaputi.
Uye apo pane zvave zvichibudirira mukugadziriswa kweHIV yakareba, masayendisiti haasati aziva kuti makuru aya aya ndeapi kana mamwe masero anogona kupa HIV chivande. Izvozvi, saka, hazvigoneki kuziva kana mabhudzi aya akanyatsobviswa nemakemikari aya.
Tsvakurudzo ichangobva kuitwa, chaizvoizvo, yakaratidza kuti kunyange zvazvo mamwe madhadhi eHIVAC inhibitor ane simba rekuita kuti HIV isati yakwana, hapana humwe humwe uchapupu hwokuti kushanda kwakadaro kwakaderedza huwandu hwezvivako.
Mamwe masayendisiti, panguva iyo, anobvunza kana "kukwezva" HIV kubva mumadzimba ayo kuchakwaniridza kupedzisa. Somugumisiro, mazvikwata akawanda ekutsvakurudza ari kutsvakurudza maitiro avo vanoita seanogona kuuraya chirwere chinenge chachangobva kubudiswa nehutachiona hushoma. Pakati pevaya vanovimbiswa kune imwe nzvimbo ndeye acitretin, chimiro che vitamini A ikozvino inoshandiswa kurapa psoriasis yakaoma kuvanhu vakuru.
Migumisiro yeLatent Persistency
Chimwe chezvinhu zvinoodza mwoyo zvikamu zveviral latency ndechokuti, kunyange munguva yaro, nguva chaiyo yeHIV mukati memasero inokonzera kupesana kunopesana kupindura. Kunyange kana munhu ari muhutano hweHIV hwakanaka uye anokwanisa kuchengetedza kusingaoneki kwehutachiona hwehutachiona, hutachiona huno husingaperi hunoputika hunoita zvishoma nezvishoma nzira iyo masero nemasukisi anopindira, zvichikurumidza kukurumidza kukwegura.
Nzira iyi, inonzi " premes senescence" , ndicho chikonzero nei vanhu vane hutachiona hweHIV kwenguva refu vari kuwedzerwa ngozi yekenza, chirwere chemwoyo, utera hwemapfupa, uye kusagadzikana kwepfungwa-uye kazhinji makore gumi kusvika kune gumi zvisati zvaitika pane zvingatarisirwa chizvarwa.
Sources:
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