Zvinoita uye Kuti Zvingaitora Sei
Kana chiremba wako akaraira Metformin nezvechirwere cheshuga kana imwe shandiso, ndeipi chaiyo iyi mishonga uye inoshanda sei? Nzira ipi yakanakisisa yekuitora nayo kuderedza madhara? Ndeipi migumisiro yakaipisisa yaungasangana nayo uye nei zvichikosha kuziva izvi?
Overview
Maererano neAmerican Diabetes Association Standards of Care, Metformin, kana ikarambidzwa, ndiyo inoshandiswa kutanga chirwere cheshuga chechirwere chechirwere cheshuga nokuti chinonyanya kushanda.
Kusiyana nevanhu vane Chirwere cheshuga 1 , vanhu vane chirwere cheshuga 2 vanoita insulini. Dambudziko nderokuti ivo vasiri kuita insulin yakakwana kana insulini yavanoita haisi kushandiswa zvakanaka. Metformin inorema inotakura mishonga inobatsira muviri kushandisa insulin. Kurema kwekutakura kunoreva kuti hazvibatanidzi nehupfumi (kana kurasikirwa) sekune mishonga yakawanda yechirwere cheshuga.
Kufanana nemishonga yose, zvisinei, Metformin inogona kuunza mamwe madhara, mamwe ayo anokosha kuziva.
Iyo Inoshanda Sei
Metformin inhengo yekirasi yemishonga inonzi biguanides , iyo inobva kuLilac yechiFrench. Metformin inobatsira kuderedza shuga yeropa kuburikidza nekushandisa insulin uye kuderedza insulin kusagadzikana (kuita kuti muviri wako uwedzere kushaya insulin.)
Vanhu vazhinji vane chirwere cheshuga chechipiri vanotakura masero akawanda-mafuta anodzivirira insulini kuti arege kuita basa rayo, pakupedzisira inokonzera masero kuti asagadzikane ne insulin. Apo masero anenge asingagoni kurwisa insulini, insulini haikwanise kutaurira shuga kubva muropa kusvika kumasero okushandisa simba, uye panzvimbo pacho, shuga inoramba iri muropa.
Somugumisiro, chiropa chinopindura nokuita shuga yakawanda nokuti inofunga kuti muviri unouda kuti uve mafuta uye pancreas inopindura nekuita insulin yakawanda. Iwe unomuka nechisimba-high blood sugar uye high insulin levels. Metformin inobatsira kugadzirisa zvisizvo nekuwedzera insulin senzwi uye nekuderedza kubudisa shuga yakagadzirwa nechiropa.
Zvimwe Zvishandiso
Mukuwedzera kune kushandiswa kwechirwere cheshuga, metformin dzimwe nguva inoshandiswa "kunze kwemavara" mu polycystic ovary syndrome (PCOS) seyamukubatsira mukubereka, sekurasikirwa kwekurema, kana kuti kurapa gestational chirwere cheshuga. Kutsvakurudza ikozvino kuongororika kunogona kuwedzera kupona kwevaya vane kanzira dzakawanda dzakadai sekenza yemapapu, kenza yemvere, uye kenza yemukomana iyo yakarapwa ne metformin. Zvimwe zvidzidzo zvakawana kuti metformin inokanganisa nzira dzakawanda mukukura kwekenza. Metformin inodzidziswawo nezvehutachiona hwehutachiona sezvo inoratidzika kuderedza dambudziko revanhu vanoenda kune dzimwe nyika, chirwere chetachiona, uye kenza yekameti.
Paunofanira Kuitora
Zvinokurudzirwa kuti vanhu vatore Metformin nezvikafu sezvo izvi zvose zvinowedzera kuwedzerwa mukati momuviri uye kunoderedza migumisiro-dumbu dzomukati, chirwere, uye kushungurudza. Kazhinji, vanhu vazhinji vatsva ku Metformin vanozvitora nehope huru. Kuti uyeuke kutora Metformin, unofanira kuedza kuitora nguva yakafanana (s) zuva rega rega.
Kutanga Metformin
Metformin mushonga unofanirwa kuwedzerwa kana kutetwa zvishoma nezvishoma kunoderedza kushushikana kwemuviri kana kwakatanga kutanga. Zvinotora nguva yakareba sei zvinotarisana nezvinotarisirwa nemutapi wehutano wako uye kuti iwe unopindura sei kumishonga (mishonga ine maitiro akawanda).
Somuenzaniso, munhu ari mutsva kuMetformin uye akarairwa 2000mg kaviri pazuva anogona kutanga nokutora 500mg kamwe chete zuva nezuva nekutya kwevhiki imwe chete. Pavhiki mbiri, achatora 500mg nechingwa chiduku uye 500mg nechingwa. Pavhiki matatu, achatora 1000mg nechingwa uye 500mg nechingwa. Uye vhiki yechina, ichava chirongwa chekurapa-kutora 1000mg nechingwa chiduku uye 1000mg nechingwa.
Muhupenyu hwose hwekutumira, unofanira kuongorora ropa rako sutu. Kana iwe uchinge uchinge uchinge uchinge uwedzere ropa rega kana zvimwe zvinetso, iwe unofanirwa kuonana nemutarisiri wako wehutano kuitira kuti mishonga inogona kugadziriswa zvakakodzera.
Kana usina mubvunzo-nguva dzose bvunza.
Migumisiro Yechiri
Vanhu vazhinji vanonyunyuta pamusoro peMetformin ndeyokuti inokonzera gesi uye chirwere. Izvi zvinogona kuwaniswa kuderedzwa nekuwedzera chiremba zvishoma nezvishoma. Kana iwe uine ruzivo kana gesi, iva nechokwadi chekutaura nemudzidzisi wako wehutano kuti ave nechokwadi chokuti uri kutora mushonga zvakanaka.
Kana uri kutarisana nemigumisiro yakaoma yakadai segesi kana chirwere, bvunza mutano wako wehutano nezvehuwandu hwekubudiswa kwechirapa ichi-iyo nguva yakabudiswa shanduko yemishonga inogona kubatsira kudzivirira matumbo emigumisiro. Izwi rakasunungurwa rinoshandiswa rinowanzoitwa kamwe chete pazuva nekutya kwemanheru.
Zvimwe Zvikamu Zvakaoma zveMetformin
Kusiyana nemishonga yakawanda yechirwere cheshuga, Metformin haina kukonzera hypoglycemia (shuga shoma yeropa.) Uyewo, kusiyana nemhando dzakawanda dzechirwere cheshuga cheshuga , Metformin haina kukonzera uremu uye inokwanisa kubatsira pakurasikirwa kwemazivi.
Dzimwe mimwe migumisiro yeMetformin inogona kunge yakanyanya kuoma. Chimwe chezvinhu izvi zvinokonzerwa nelactic acidosis. Kunyange zvazvo zvidzidzo zvitsva zvinoratidza izvi ndezvisina kujairika izvo zvingave zvisingabatanidzi zvakananga neMetformin, njodzi yeactic acidosis inowedzera kune vose vane zvirwere zvepfungwa zvisina kusingaperi nevaya vane chirwere chechiropa.
Lactic acidosis inowanikwa apo lactic acid inowedzera muropa uye inokonzerwa nemuviri unofanirwa kushandura shuga pasina kuvepo kweokisijeni panzvimbo pokuti aerobically. Vanhu kwete paMetformin vanogona kukura lactic acidosis kubva pakubata muviri kwakasimba, kurwara kwakakomba, kukuvadzwa, kana kushaya zvinodhaka.
Zviratidzo zve lactic acidosis inobatanidza Metformin inogona kuva yanyoro kana yakaoma uye inogona kusanganisira kupfupika kwefema, kuzvimba, kushaya simba, uye kurwadziwa kwemasuru. Kana iwe uine zviratidzo izvi paunotora Metformin unofanirwa kutsvaga rubatsiro rwechiremba pakarepo. Kana lactic acidosis inenge isingateereri, inogona kuguma nezvinetso zvakakomba kana kunyange rufu (kusungwa kwemwoyo.)
Metformin inogona kukonzera kushayikwa kweB12 , dambudziko iro rinozivikanwa se "rinorwara anemia" uye rinogona kutungamirira kukuvara kwekusagadzikana kwemagetsi. B12 kushaikwa kunobatanidzwawo nehuwandu hwekurohwa . Zviratidzo zvokutanga zvekushaya B12 zvinogona kusanganisira anemia, kurira munzeve, uye kuora mwoyo. Kune avo vanoshandisa metformin, zvakakosha kuti maB12 ako aongororwe kuitira kuti kushaya vitamini kunogona kugadziriswa kusati kwaitika kushayikwa.
Mazita Anowanikwa
Metformin inogona kuenda nemazita mazhinji, ayo anosemesa vanhu vakawanda. Mazita anowanzoenderana neMetformin anosanganisira:
- Fortamet
- Glucophage
- Glucophage XR
- Glumetza
- Riomet
Metformin inogonawo kusanganiswa nemimwe mishonga yechirwere cheshuga. Kana usina chokwadi chauri kutora kana kuti mishonga yako inoshanda sei iwe unofanira kubvunza mupiro wako wehutano:
- Actoplus Met (ine Metformin, Pioglitazone)
- Avandamet (ine Metformin, Rosiglitazone)
- Glucovance (ine Metformin, Glyburide)
- Invokamet (ine Metformin HCl / Canagliflozin)
- Janumet (ine Metformin, Sitagliptin)
- Janumet XR (ine Metformin, Sitagliptin)
- Jentadueto (ine Metformin, Linagliptin)
- Kazano (ine Metformin / Alogliptin)
- Kombiglyze XR (ine Metformin, Saxagliptin)
- Metaglip (ine Metformin, Glipizide)
- Prandimet (ine Metformin, Repaglinide)
- Synjardi (ine Metformin, Jardiance)
- Xi Guo XR ( ine Metformin HCl, Dapagliflozin)
Shoko Rinobva
Metformin isarudzo yakanakisisa yemishonga kune vanhu vane chirwere cheshuga chechirwere uye inokurudzirwa semishonga inosarudzwa inotanga panguva yekuongororwa kune avo vasina mvumo yekutsanangurira (zvikonzero zvisingashandisi mushonga.) Kubva pamagariro ayo hazvisi kubudirira kune vanhu vane chirwere cheshuga chechirudzi Metformin inoshanda kuderedza insulin kumira mukuwedzera kune dzimwe nzira dzekuita. Kusiyana nemishonga yakawanda yemaashuga, haisi kukonzera uremu uye haine hunoti hwehutano hwe hypoglycemia , iyo inogona kunge yakaoma zvikuru.
Zvimwe zvikanganiso zvakadai sedhara uye gasi zvinowanzovapo paunotanga mishonga, asi inogona kuderedzwa nekunyatsotarisa chiremba zvichikwira kwenguva yakareba. Zvisingabatsiri asi zvinokonzerwa nemigumisiro inogona kusanganisira lactic acidosis nekushaya B12. Kuziva kuti zvinogona kuitika zviratidzo zve lactic acidosis uye kuongorora B12 kunogona kukanganisa zvinetso zvakakomba zvikuru.
Nepo metformin isarudzo yakanakisisa mukuronga rudzi rwechipiri chirwere cheshuga, mararamiro anoita mararamiro akadai sekudya kwakanaka uye kuyerwa kwezvishoma (kune avo vanopfuura kudarika zvakanyanya) ndiyo nzira dzinonyanya kukosha yekugadzirisa insulin kudzivisa uye kudzivisa zvinogona kuguma kwenguva refu zvechirwere cheshuga.
> Sources:
> American Diabetes Association. Maitiro ekurapa mune chirwere cheshuga -2017 Akashandurwa kuVatori Vanonyanya Kuchengetedza.
> Chapman, L., Darling, A., uye J. Brown. Sangano Pakati PeMetformin uye Vitamini B12 Kukwana Muvarwere Nechirwere Cheshuga Chirwere cheshuga: Kurongeka kweSarudzo uye Meta-Kuongorora. Chirwere cheshuga uye Metabolism . 2016. 42 (5): 316-327.
> Kasper, Dennis L .., Anthony S. Fauci, naStefano L .. Hauser. Harrison's Principles of Internal Medicine. New York: Mc Graw-Hill Dzidzo, 2015. Print.
> Lalau, J., Kaibaf, F., Protti, A. uye al. Metformin-Yakabatana neCctic Acidosis (MALA): Kufamba Kunyorera Paradigm Itsva. Chirwere cheshuga, Kuwedzera muviri, uye Metabolism . 2017 Apr 17. (Epub mberi kwekudhinda).
> Thomas, I., naB. Gregg. Metformin; Mutsva weNhoroondo Yake neHamangwana: Kubva kuna Lilac kusvika kumakore mazhinji. Chirwere cheshuga . 2017. 18 (): 10-16.