Chikonzero nei Metformin Vashandi Vanofanira Kuchenjerera Vitamini B12

Kunyange zvazvo isina kuratidzirwa kurapa polycystic ovary syndrome (PCOS), metformin ndiyo inowanzopiwa mishonga inobatsira vakadzi vanotambura nemamiriro acho ezvinhu. Kutsvaga kutsvaga kutsvaga kuri kuratidza ukama pakati pekushandiswa kwemazuva ekupedzisira metformin uye kushayikwa kwevitamini B12, asi vanowanzopa varapi vehutano vanongowanzoona B12 mumamiriro ekushandisa metformin. Kushaikwa kwevhitamini B12 kunogona kukonzera kukanganisa kwakasimba uye kwechigarire kwehutano uye nenyonga.

Hezvino kuti uzive nezve vitamini B12 kana iwe ukatora metformin.

Chii Chinonzi Metformin?

Metformin inoshanda se insulini-sensitizer kuti kuderedze kugadzirwa kwako kweglucose uye inowanzotaurwa kuvanhu vane chirwere cheshuga chechipiri nekuda kwechikonzero ichi. Mamwe mazita e metformin anosanganisira glucophage, glucophage XR, glumetza, uye fortamet.

Metformin inoderedza ropa yehuga uye insulin maitiro nenzira dzakasiyana-siyana: Inoderedza chibereko chechiropa cheglucose, inowedzera kunzwisisika kwechiropa chako, musuru, mafuta, uye masero kune insulini muviri wako unoita, uye inoderedza kunwa kwemakhahydrates iwe unopedza.

Metformin yakaratidzwa kuvandudza insulini pamwe nemakirwe emuviri (cholesterol) muvakadzi vane PCOS uye inogona kubatsira kuvandudza ovulation.

Metformin Use uye Vitamin B12 Kukwana

Chirwere Cheshuga Kudzivirira Zvirongwa Zvedzidzo Chidzidzo (DDPOS) inomirira imwe yezvidzidzo zvakakura uye zvekare kupfuura zvekurapa kwemasformin. Kuongorora patsva kweDDPOS yakabudiswa mu Journal of Clinical Endocrinology uye Metabolism yakatarisa maB12 evanhu vane prediabetes vakatora 850 mg Metformin kaviri zuva rimwe nerimwe ndokuzvifananidza naivo vanotora placebo.

Vitamini B12 mazinga akaongororwa pamakore mashanu ne13.

Migumisiro inobva kuDDPOS yakaratidza kuti kushandiswa kwenguva yakareba metformin kushandisa yakawedzera mukana wema vitamini B12. Pamakore mashanu, 5.2 muzana yevashandisi vesformin vaiva nechepasi serum B12. Mumakore gumi nematanhatu, 9.2 muzana yevashandi veformformin vaiva neB12 pasi. Apo kutonga kwezera, zvepabonde, uye BMI, paiva ne13 muzana yakawedzera ngozi ye B12 yekushaikwa kwegore rimwe nerimwe rekushandiswa kwemasformin.

Zvinotendwa kuti metformin inogona kukanganisa kunwa kwevhitamini B12 mune yeaum yemukomana muduku. Hakusi chete mavhitamini B12 akabatwa mukudzidza kweDDPOS, asi maitiro e homocysteine, chiratidzo chepfungwa yemwoyo, yakawedzerwa kwechinguva muvashandisi vesformin.

Zvimwe zvidzidzo zvakaratidza kuti metformin inogona kukanganisa mazana e vitamini B12 mune zvishoma semwedzi mitatu yekushandiswa. Kuongorora kwakarongeka uye kuongorora meta kwakatarisa vanhu vane chirwere cheshuga chechipiri uye vakadzi vane PCOS vakatora metformin. Migumisiro yavo yakawana yakakwirira metformin dose, vanhu vasina kukwana vaiva mu vitamini B12 uye kuti metformin yakaderedza mavhitamini B12 mumakore maviri akareba (makore matatu) uye pfupi (

Ivhareji yeji ye metformin yevakadzi neCPOS is 1,500 mg kusvika 2,000 mg zuva rega rega. Ruzhinji rwevakadzi vane PCOS vane huwandu hwakawanda hwemetrafini yekushandisa kwenguva yakareba, kuwedzera dambudziko ravo rekushaya vitamini B12.

Kukosha kweVithamini B12

Mavitamini anogadziriswa nemvura, B12 anokosha pakuita mishonga, kushandiswa kwepfungwa, DNA synthesis, uye tsvuku yeropa rekuumba. Vitamini B12 inonyanya kuwanikwa mumhuka yemiti. Avo vanotevera kudya vegan vanofanira kuwedzera zvokudya zvavo ne vitamini B12. Izvo zvakakurudzirwa zuva rega rega mavitamini B12 kune vakawanda vakura ndeye 2.4 mcg.

Zviratidzo zvekushaya B12 zvinosanganisira mamwe marudzi ekushaya ropa, neuropathy (kushungurudzika kwemishonga), kusuwa kusingaperi, kuyeuka kurasika, kuvhiringidzika, mafungiro ekuchinja uye kunyange kuora mwoyo.

Kushayikwa kwevhithamini B12 kwakaipisisa, kunokanganisa mafungiro uye simba uye kunogona kuguma neuropathy isingaperi uye isingagadziriswi. Dzimwe nguva kutora multivitamin ine vitamini B12 inogona kuguma nekushayikwa kwevashandisi vesformin. Vanhu vanotora metformin vanofanira kunge vane mavitamini B12 avo anoongororwa gore roga roga uye vanowedzera kudya kwavo zvakakodzera kwavari. Izwi re vithylcobalamin yevhitamini B12 mune chimiro chechimiro (pasi pomururimi) inonyanya kukonzerwa nemuviri.

Kushaya Bhijitini B12 Kunowanikwa Sei?

Ropa remuropa rinogona kuongorora mazana e vitamini B12. Izvo zvave zvataurwa kuti mabhesi emakero aya evanhu vemazuva maviri B12 akaiswa pasi zvakanyanya uye kuti zviratidzo zvekushayikwa zvinogona kuratidzika mumasero pasi pe 400 pg / ml.

Kutarisa methylmalonic acid (MMA) inogona kuongororwa zvinogona kuratidza zvakajeka mavitamini B12.

Pasi pepamusoro: Kana ukatora metformin, bvunza chiremba wako kuti aone mavitamini B12 ako gore negore uye wobva wawedzera kudya kwako ne vitamini B12 kuti udzivirire zvinetso zvekushaiwa.

_Sources:

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