Angiotensin inoshandura enzyme (ACE) inhibitors ndeyomushonga wemishonga iyo yakaderera ropa. ACE inhibitors inoshandiswa kurapa huwandu hwehutano hwepamusoro (high blood pressure), chirwere chetachiona chetachiona uye kukanganisa kwemwoyo, nekubatsira kudzora kufambira mberi kwechirwere cheshuga uye chirwere chepfungwa.
Overview
Izvi zvirwere zvirwere zvinowanzoenda mumaoko; kukwirira kweropa kunowanzoonekwa pakati pevanhu vane chirwere cheshuga.
Kuwedzera kweropa kunobatsirawo kukura kwechirwere cheshuga nephropathy (chirwere chepfungwa).
Uyezve, avo vane chirwere cheshuga vanowanzova nemigumisiro yakaipisisa (kwenguva yakareba yekurapa, nguva refu yekudzikinura uye njodzi dzakakwirira dzehutachiona) kubva pamatambudziko makuru emwoyo. Nokudaro, vanopa utano hwehutano vanorapa hutachiona hwepamusoro mukukanganiswa nechirwere cheshuga .
Kunyange zvazvo ACE inhibitor isinganatsiki zvakanyanya shuga yeropa, inogona kuita kuti kuve nekushuga kweropa kuwedzerwa nekuwedzera kwekunzwa kwemuviri kune insulin. Insulin inobatsira muviri kuti uwedzere gasiko (shuga) uye uutungamirire kubva kubva muropa kusvika mumasero, apo unoshanda sechinhu chinopa simba.
Vakawanda ACE inhibitors varipo muUnited States, kusanganisira Capoten (captopril), Prinivil uye Zestril (lisinopril), Vasotec (enalapril), Lotensin (benazepril), Altace (ramipril), Accupril (quinapril), Monopril (fosinopril), Mavik ( trandolapril), Aceon (perindopril) uye Univasc (moexipril).
Maitiro Avanoita
ACE inhibitors inoderedza kukanganiswa kweropa nekudzivirira muviri kuti urege kubudisa hormone angiotensin II. Angiotensin II inokonzera vasoconstriction (kuderedza mitsipa yeropa) nekuchengetedza kwemvura, zvichiita kuti iwedzere. Nokuderedza kudzvinyirira kweropa uye kuchengetedza kwemvura, ACE inhibitors anobatsira kudzora mwoyo kusakona.
ACE inhibitors inogonawo kudzivirira nekudzivirira chirwere cheshuga nephropathy (chirwere chepfungwa) uye kubatsira kudzora chirwere cheshuga chetinopathy (matambudziko eziso). ACE inhibitors haiti kuderedza mwoyo kana shuga yakaderera yeropa.
Nhoroondo yekushandisa
ACE inhibitors ave FDA-inogamuchirwa kurapa huwandu hwehutano kubva muna 1981. Nokufamba kwenguva, ACE inhibitor iko rawedzerwa zvinoshamisa kutarisa chirwere chemwoyo nemamiriro akafanana.
Ndivanaani Vanofanira Kudzivisa
Vanhu vane chirwere chakanyanya kwazvo chemuropa (hypotension), kana kuti avo vane zvirwere zvekurwisana kana kukanganiswa zvine chokuita neACE inhibitors, havafaniri kushandisa ACE inhibitors. Uyewo havasi ivo vane renal artery stenosis, vakadzi vane pamuviri nevadzimai vanoedza kubata pamuviri.
Vanhu vane kukuvadza kwepimpadzo kunoda kuchinjwa dosing yeACE inhibitors.
Migumisiro Yechipfuva uye Ngozi
Mishonga yose yeropa mishonga inopinza dambudziko rekushaya simba, uye zviratidzo zvinosanganisira kuchena, chizivo, chirwere, kusuruvara uye kukanganisa kurasikirwa kwekuziva.
Kazhinji, ACE inhibitor inogona kukonzera shuga yakaderera yeropa (hypoglycemia). Izvi zvinowanikwa kune vanhu vane chirwere cheshuga vane mazinga ega shuga ayo akangodaro akachengetedzwa zvakanaka nekudya uye mamwe mishonga inorwisa antidiabetic.
ACE inhibitor inogona kukonzera kune vamwe vanhu. Kana izvi zvichiitika, vanofanirwa kukurukurirana izvi nevanopa utano hwavo, avo vanogona kutsiva ropa rega rega remishonga.
Mimwe ye 'Off-Label' Uses
ACE inhibitor inogona kubatsira kudzivirira kutanga kwechirwere cheshuga . Mukuwedzera, ACE inhibitors inogona kubatsira kudzora kusagadzikana kwemazwi, kunyanya kana yakashandiswa mushure mekurwa kwepfungwa.
ACE inhibitors inoshandiswa kubva pahutano mukurapa zvirwere zvakadaro se rhumumine arthritis, migraines, Raynaud's phenomenon uye Bartter syndrome.
Health Tips
Angiotensin receptor blockers (ARBs) yakafanana neACE inhibitors. Vanhu avo vanokonzerwa neACE inhibitors kana vanoita chifukidziro chakakonzerwa neACE inhibitors vanogona kutendeukira kuAARB nemigumisiro yakanaka. Vanhu vane chirwere cheshuga vanofanira kugara vachitaurira varwere vavo nezvehutano pamusoro pemamwe mishonga uye mishonga yepamusoro, pamwe nemishonga chero ipi zvayo uye zvigadzirwa zvinowanzoshandiswa, zvisati zvatanga kutora ACE inhibitors.
Vanhu vari paACE inhibitors vanofanira kutarisa nevatapi vehutano hwavo vasati vatanga chero mishonga mitsva.
Sources:
Bakris, George L. "Kurapa kweHypertension muShuga Cheshuga Mellitus." UpToDate.com. Dec. 11, 2015. UpToDate .. (kubhadhara).
Kaplan, Norman M., naBurton D. Rose. "ACE Inhibitors muArapa yeHypertension." UpToDate.com. 2014. UpToDate. (kubhadhara)
McCulloch, David K., naRa. Paul Robertson. "Kufanotaura uye Kudzivirira Chirwere Chechipiri Cheshuga Mellitus." UpToDate.com. 2007. UpToDate. 7 Sep. 2007. (kubhadhara).