Zviratidzo zvekupa mutoro kurasikirwa uye kuderedza ropa sutu
Uri mumwe munhu ane chirwere cheshuga kwemakore anoverengeka uye iwe haukwanisi kudzora shuga yako zvakare pamishonga yemuromo? Chirwere cheshuga chirwere chinopfuurira uye dzimwe nguva kugadziriswa mumishonga yemishonga inofanira kuitwa kuti ibatsire kuronga shuga yeropa.
Kakawanda, vanhu vane chirwere cheshuga vanogona kubatsirwa nekushandisa mushonga unorasikirwa (kwete insulini) pamwe nemishonga yavo yemuromo.
Kwete-insulin mishonga inokanganiswa, inonzi GLP-1 agonists (yakadai neByetta naVictoza), yakaratidzwa kubatsira rubatsiro mushure mekudya kwehuga yega uye kuderedza uremu.
Chii Chinonzi Bydureon?
Imwe GLP-1 agonist, Bydureon, inogara kwenguva yakaita maitiro emishonga Byetta iyo inopiwa kamwechete pavhiki. Bydureon i-GLP-1 (glucagon-like peptide 1) agonist iyo inokurudzira kuvhara insulini apo inosangana neglucose.
Iyo yakaratidzawo kuchengetedza beta cell function (beta masero anoita insulini) uye yakaratidza kuti inokurudzira kuora kura nekukanganisa gastric kubvisa uye kuwedzera manzwiro ekuzara. Zvidzidzo zvakaratidza kuti vanhu vanotora Bydureon vanorasikirwa nemavhareji anenge mapaundi mashanu nemwedzi mitanhatu yekutora mishonga uye vakaratidzirwa kuichengetedza negore rechitatu.
Kutsvakurudza kutsva kwakaitwa naSyraZeneca (vadzidzisi ve Bydureon) kunoratidza kuti kupera kamwe kamwe-kwevhiki kwekusimudzirwa kwe autoinjection kunowedzera kuderedza kuderedza muHbA1c (-1.4 vs -1.0) kupfuura Byetta kujowa kwemazuva maviri.
Varwere muexenatide autoinjection boka uye Byetta boka raive nekuderedza kwakafanana kwehutano hwehuviri hunoreva (-1.5 kg vs. -1.9 kg, zvichienderana; p-value = 0.4).
Zvimwe zvidzidzo zvakaratidza kuti kana zvichienzaniswa ne insulin, varwere vachishandisa Bydureon vanorasikirwa nehuwandu-chirevo chega chega cheshuga chekutonga ropa.
Ropa Sukari Control
Kunyange zvazvo kuongororwa kwekliniki kwakaratidza kuti kurapwa neBydronon kunogona kubatsira kuderedza A1c ne inenge 1.5 muzana, Bydureon haisashandiswi semushonga wokutanga wehutachiona hwehuga. Pane kudaro, inowanzoshandiswa sechipiri kana chechitatu mutengesi pamwe chete nemetformin kana sulfonylurea.
Kana uri kutora sulfonylurea, chido chako chingada kuchinjwa kuti kuderedze njodzi ye hypoglycemia . Bydureon inofanira kushandiswa pamwe chete nekudya uye kuita zvekurovedza muviri uye haisati yashandiswa kushandiswa sekurehwa kwechiremera chemishonga.
Kutora Bydureon
Pakupedzisira, Bydureon yaiwanikwa chete achishandisa siriniti yaiva yakareba uye yakareba. Kunyangwe chirwere chacho chaingova kamwe chete pavhiki, vamwe vanhu vakanyunyuta pamusoro pokushungurudzika. Zvisinei, ikozvino Bydureon inowanikwa kuti ishandiswe kuburikidza nepeni. Peni inogona kuva yakanyatsogadzikana uye yakashandiswa kushandiswa kupfuura siriti.
Bydureon inofanirwa kuiswa mujenya mutsvuku mumashupu uye kwete mumusungo kana mutsara. Iwe unogona kuvhara Bydureon munzvimbo dzakafanana iwe unogona kuisa insulin-mimba (maviri masendimita kubva pamimba yako yebonde), kunze mahudyu, kumashure emaoko ako ekumusoro. Iwe unogona kushandisa nzvimbo imwe chete yevhiki nevhiki, edzai kusashandisa nzvimbo imwechete chaiyo.
Dzimwe nguva vanhu vanoona kunetseka kana kutsvukira panzvimbo yejojo.
Danaidza mubatsiri wako wehutano pakarepo kana iwe uine kurwadziwa kwakanyanya, kupfugama, maronda, vanga rakazaruka, kana ganda remafu panzvimbo yako yejojo.
Ndiani Akasarudzika Bydureon?
Kurukura nemutarisiri wako wehutano kana iwe uri mukana weBydureon. Bydureon haisi iyo inoshandiswa kushandiswa semutoro unorema uye inowanzoshandiswa pamwe chete nemimwe mishonga yechirwere cheshuga. Kana iwe uri mumwe munhu ane chirwere cheshuga chechipiri chirwere cheshuga chisingawani pane chinangwa uye chinogona kukwanisa kurasikirwa nechimwe , kupfuura Bydureon inogona kunge iri sarudzo kwauri.
Ndiani Asingafaniri Kutora Bydureon?
Mune zvidzidzo zvemhuka, Bydureon akaita kuti makonzo awedzere matumire ejeni yekroroid.
Nokudaro, Bydureon inopesana nevarwere vane nhoroondo yega yega kana yemhuri yemararamiro eradio medullary (MTC) uye nevarwere vane Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Vanhu vane shungu dzekuwedzera kana kuti chero zvigadzirwa zvezvikamu havafaniri kutora Bydureon.
Usati watora Bydureon, unofanirwa kutaurira wako kana iwe une nhoroondo yepascreatitis, matombo mumaruva ako (gallstones), nhoroondo yekudhakwa, kana hutachiona hwepamusoro-soro yegriclyceride sezvo Bydureon inogona kunge isingafananidzi kwauri. Paunotora Bydureon, kana uchinetseka kurwadziwa kwepamuviri kusingaendi, unofanirwa kuonana nemutarisiri wako wehutano pakarepo sezvo izvi zvingava chiratidzo chekuputika. Bydureon haina kuitirwa varwere vane chirwere cheshuga cheshuga.
Iyi Ndiyo Chete Yevhiki Rimwe Chete Inogadziriswa Mishonga?
Parizvino, Bydureon ndiyo chete yevhiki imwe neimwe inopindwa mishonga inopindwa mishonga pamusika. Asi, mamwe makambani ari kushanda pamusoro pekugadzira uye ari kutarisira kuongororwa kwekliniki. Bydureon inongova kutanga kwekuwedzera kwechikwata cheshuga.
Migumisiro Yechiri
Nokuti Bydureon inononoka gastric kubvisa, zvinowanzovhiringidza zvinosanganisira kushungurudza uye kurutsa. Nausea inowanzoitika kana uchitanga mishonga uye inoderedza nguva apo muviri unoshandisa mushonga. Dzimwe mimwe migumisiro inosanganisira misoro, chirwere chemashuga, kubwinya panzvimbo yejojo.
> Sources:
> Wysham, Carol, uye. al. DURATION-NEO-1: Kuwedzerwa kweHbA1c hukuru nekumiswa kwenguva refu kamwe chete ne autoinjector pen vs exenative kaviri zuva rimwe nerimwe mukusakwanisa kutaridzirwa chirwere cheshuga chechipiri. Gunyana 29, 2014.
> Ahren, B & Schmitz, O. GLP-1 receptor agonists uye DPP-4 inhibitors mukurapa rudzi rwechipiri chirwere cheshuga. Horm Metab Res. 2004 Nov-Dec; 36 (11-12): 867-76. Svondo 24, 2014.
> Reid, Washington, MD. Kusarudza GLP-1 receptor agonists kana DPP-4 inhibitors: kuenzana nechipatara cheuchapupu. American Diabetes Association. September 25, 2014.
> Zvokudya uye Drug Administration. Bydureon Mishonga Guide . September 25, 2014.