Masayendisiti "vanodzidzisa" masero emumunwe kuti ave vashandi vanobudirira
Mumakore achangobva kupfuura, vatsvakurudzi vakaisa hurukuro yakawanda pane zvakasiyana-siyana zvekudzivirira zvirwere zvekudzivirira hutachiona hweHIV , umo muviri wemuviri waro unosimudzirwa kuti uzvidzivirire zvakasimba pamusoro pesirwere inopinda. Muvanhu vakawanda, simba remuviri yekuzvidzivirira pachako rinosangana nenguva yakawanda seinoti "muurayi" masero, anozivikanwa seCD8 + T-cells , zvishoma nezvishoma anorasikirwa nekwanisi rekuziva chirwere ichi chinokurumidza kuchinja.
Kuomesa nyaya, HIV inokwanisa kukurumidzira kuzvidzivirira mune izvo zvinonzi latent reservoirs -izvozvima mavhariyoni ekuchengetedza nzvimbo-apo inogona kuramba ichienderera mberi kwemakore uye kunyange makumi emakore kunyange pakatarisana nehutachiona hwehutachiona hwehutachiona (ART).
Kuti zvive nehutachiona hweHIV kubva mumuviri, masayendisiti haazofaniri kungobudisa dambudziko reHIV kubva munzvimbo idzi tsvene asi kuti azviuraye pamwe chete nechinokonzera kukanganisa zvachose kana nekukonzera kuwedzerwa kwemuviri wezvirwere (kana kuti zvose). Kunyange sevanotsvakurudza vari kutsvaga nzira itsva uye dzevimbiso dzingakonzera kuti HIV ibudise pachena, kusvika panguva ino hatisati tawana nzira dzekuuraya nayo hutachiona kana ikasunungurwa.
Masayendisiti paJohn Hopkins University School of Medicine, akatungamirirwa nemukuru mukuru wepurezidhendi Robert Siciliano, MD, Ph.D., havana kungojekesa kuti sei ichi chiitiko chinowanzoitika asi vakaronga nzira inogona kuvhura musuo wekugadzira chirwere chinokwanisa kubvisa zvachose kurara kwehutachiona hutachiona.
Muenzaniso we "Kurovedza" Kuuraya T-Cells
Mukutsvakurudza kwavo, Siciliano neboka rake vakashuma kuti HIV itsva ichangobva kusunungurwa inowanzoshandurwa kuti isanyatsonzwisisike kuCD8 + T-seli. Vanotenda kuti kuburikidza neku "kudzidzisa" masero aya anochengetedza kuti ave nani uye auraye masero ane hutachiwana anopa huno-inozivikanwa seCD memory + T-cells -inokwanisa kukwanisa muviri weHIV kana, kana zvisingaiti, kudzora hutachiona pasina kushandiswa kwemishonga.
Vatsvakurusi vakatanga nekushandisa ropa sampuli kubva kune varwere vane HIV vane gumi nevaviri, 10 vavo vakatanga ART panguva yemwedzi mitatu yehutachiona uye vakasara avo vakatanga chirwere munguva yechirwere chisingaperi chetachiona apo zviratidzo zvekutanga zvezvirwere zvechirwere zvinotanga kuonekwa.
Hazvishamisi kuti avo vakatanga maPirisi kare vakange vane HIV yakawandisa asi avo vakatanga gare gare vainzi "kupukunyuka" kushanduka kwakaita kuti chirwere chepuroteni chizvivanze kubva pakuonekwa. Zvisinei, izvo Siciliano nevatsvakurudzi vake vakakwanisa kuwana ndezvipi zvose zvisina kuchinja uye zvakachinjwa HIV zvakachengetedza chikamu chiduku chepuroteni yavo yepuroteni yepakutanga. Nokutanga ma CD8 + T-cells kuti vaone iyi protein "marker," masayendisiti anotenda kuti sero inogona kunge yakakwanisa kutarisa nekuparadza utachiona.
Mune in vitro labor studies, vaongorori vakatanga kutanga vauraya T-masero kubva kune varwere vavo uye vakavaisa pachena kune hutachiwana hutachiona hweHIV kana kubatana kwehutachiona hweprotini chunks hwakatorwa kubva kune zvose zvakashandurwa uye zvisina kutapurirwa HIV. Muenzaniso wacho wakabva wapera pachena kuti ane CD4 + T-masero anokonzerwa neHIV akatorwa kubva kune varwere vanozivikanwa kuti vane kuchinja kwekubuda. Mushure mokuongorora zviitiko, Siciliano neboka rake vakaona kuti muurayi T-seli akazarura kune vose vane mutachiona uye vasina kutapurirwa HIV vakakwanisa kuuraya 63% emasero ane hutachiona apo avo vakaratidzirwa neAIDS vane hutachiona hwe HIV vari kungokwanisa kuuraya 23%.
Vatsvakurudzi vakabva vatsvaga mienzaniso mumakonzo evanhu (kureva kuti, mhando dzakagadzirwa kuti dzive nehutachiona hwevanhu) iyo imwe neimwe yakave yakarongedzwa neHIV. Apo makonzo akazadza gare gare-chirwere , chirwere chechirwere uye chakakonzerwa neimwe kana kuti imwe "yakarovedzwa" muurayi T-seli samples, mhinduro dzaive dzakafanana. Vose veavo vakagamuchira muurayi T-masero akachengetwa neHIV chete yakafa. Avo avo vakanga vagamuchira T-masero vakafadzwa neutachiona uye vasina kuchinja mutachiwana hweHIV vakawana zvakadzama, zvuru zvine gumi zvakaderera muhutachiona hwehutachiona , pamwe nevamwe vakadzvinyirirwa kuti varege kuonekwa zvakajeka mazinga.
Tsvakurudzo yaJohn Hopkins inopa uchapupu hunobatsira hwekupedzisira hunozopedzisira huchaita nzira yakakwana ye HIV inopedza kana kutonga.
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