CD20 iCCD marker-molecule iri muchitokisi iyo inogona kushandiswa kuzivisa uye kuisa imwe sero mumuviri. CD20 inowanikwa pamusoro pemasero eB, asi ngatidzokerei uye ita kuti izvi zvive nyore kunzwisisa.
Chii Chinonzi CD Markers?
CD marker ma molecules anowanikwa pamusoro pemasero mumitumbi yedu. Iwe unogona kuvanzwa vachinzi maantigen - uye antigen inonyanya chinhu chiri pamusoro pekamuri iyo inogona kuzivikanwa nemuviri wedu wesimba.
Semuenzaniso, masero edu eropa anokwanisa kuona maantigen pamusoro pevavengi vanokonzera mabhakitiriya uye masero machena ane simba rekupindura kune izvo zvinonzwisisika sekutyisidzira.
Kese kese mumitumbi yedu ine CD marker, uye zvachose pane zvinopfuura 250 zvei antigens. Izwi CD rinomirira masango ekusiyanisa - uyezve, imwe nzira iyo maitiro ezvisikwa akasiyana anogona kuudzwa kunze. Kuva akakwanisa kuziva idzi maCD zvinogona kuve zvakakosha kana iwe usingakwanise kuve nokuona rudzi rwechiremera.
CD Markers, B Cells, uye T Cells
Lymphomas ndiwo kanzira dzechirwere chemuchena weropa rinonzi lymphocytes. Kune miviri miviri mikuru ye lymphocytes - B lymphocytes kana masero eB , uye T lymphocytes kana T seli . Zvose zviri zviviri zve lymphocytes dzinobatsira kudzivirira miviri yedu kubva kune utachiona.
B masero nemamwe masero eT ane mabasa akasiyana, uye kenza yega rimwe nerimwe rema B anoshanda nenzira dzakasiyana kubva kumakanera emasero eB.
Pasinei nezvose izvi zvakasiyana, zvinogona kuva zvakaoma kutaurira musiyano pakati pe 2 pasi pekroscope. Mhando yakafanana 2 mapatya akafanana anoita zvakasiyana zvakasiyana uye anopindura kuvanhu zvakasiyana asi tarisa zvakafanana kune kunze.
Chii chinonzi CD20?
CD20 is antigen inowanikwa pamusoro pemasero eB asi kwete maT cell.
Muenzaniso wekuti CD-20 inogona kushandiswa sei kutaurira masero aripo apa:
Kune mararamiro maviri akasiyana kwazvo akafanana nemapatya akafanana pasi pe microscope, asi ane maitiro akasiyana-siyana ezvirwere uye anopindura zvakasiyana nezvirwere: Kupararira kukuru B cell lymphoma (DLBCL) chirwere chinosanganisira masero eB. Pasi pemakrosikopu masero anotarisa semasero anokonzera T anowanika muaplastic huru cell lymphoma (ALCL) . Zvose izvi zvekenza zvine chikuru, "kenza" inotarisa masero uye inogona kunge isinganzwisisiki. CD20 inogona kushandiswa kutaurira musiyano pakati peiyi makondombera maviri mumigumisiro iyoyo yekuedza kweCD20 inowanzova yakanaka pane DLBCL asi isina kunaka kweAlCL.
Unoedzwa Sei?
Imwe nzira inokosha inonzi immunohistochemistry (IHC) inoshandiswa kuzivisa CD20 uye inotarisa kana chirwere chisina kuchena chekenza ropa (lymphocyte kunyanya) inonzi B-cell kana T-cell.
Inobatwa Sei?
Kurapa uye kufungidzira kweB-cell uye T-cell lymphomas zvinowanzosiyana.
Imwe mitsva yemishonga inonzi monoclonal antibodies inoshanda zvakanaka kune mamwe lymphomas. Sezvo miviri yedu ichiita zvirwere zvinorwisa mabhakitiriya uye mavairusi, majekiseni anonzi monoclonal manotsi anogadzirirwa kurwisa kenza masero.
Uye sezvinongoita miviri yedu inoita zvirwere zvinoratidzira maitiro emabhakitiriya mavairusi, izvi zvinokonzerwa nemasikironi anoona maantigen panzvimbo yekenza masero; mune iyi nyaya, CD20.
Kushandisa monoclonal antibody iyo inosungirirwa kuCD20 ichashanda chete nekenza ine CD20 antigens pamusoro, zvakadai saAllic mumufananidzo wakaita pamusoro apa.
Monoclonal Antibody Treatment uye CD20
Kune mamiriyoni akawanda emasikirini emvura ayo ari kushandiswa iye zvino. Izvozvo zvinoshandiswa neMonoclonal antibodies zvinobata B cell lymphomas uye leukemias neCD20 antigen pamusoro pemasero dzinosanganisira:
- Rituxan (rituximab)
- Zevalin (ibritumomab tiuxetan)
- Bexxar (tositumomab)
- Gazyva (obinutuzumab)
- Arzerra (ofatumumab)
Kunyange zvazvo vose vakasunga CD20, kune kusiyana pakati pezvirwere izvi. Zvimwe zvinonzi se chimeric yakadai se rituximab, zvinoreva kuti bio-engineers vanoshandisa 'kusanganiswa kwezvigadzirwa zvekuvaka' kukashandura anti-antibody, vamwe vanhu, imwe mouse; dzimwe dzinonzwisiswa (obinutuzumab) uye dzimwe dzakazara vanhu (ofatumumab), zvinoreva kuti zvikamu zvose zvinobva kumunhu zvekare => mapuroteni emvura. Zvadaro, chimwe chinhu chinokonzera ndechokuti vamwe vanobatanidzwa ne radioactive elements (ibritumomab tiuxetan uye tositumomab).
Kutsungirira Lymphoma
Sezvawasvika peji ino, uri kutora danho rakakura mberi pakuva mubatanidzwa mukushingaira mukutarisira kwako. Ongororo dzakawana kuti kudzidza zvakawanda maererano nehosha yako sezvinobvira , uye kutamba basa rakaoma mukutarisira kwako, kunobatsira kwete kungobata chete nekuzvidya mwoyo kwekenza asi kunogona kubatsira nemigumisiro zvakare. Svika kumhuri neshamwari. Tarisa mukati mekunakirwa kwevanhu vari muIndaneti yevanhu vane leukemia uye lymphoma - vanhu vamunogona kuwana 24/7 kutsigira uye nemibvunzo. Uye iva nechokwadi chokuti iwe uri mupepeti wako mukuchengetedza kenza yako . Mishonga iri kuchinja uye oncologists kwete kungorega chete asi tarisira kushanda pamwe chete newe kuti uratidze chirongwa chekurapa chinonyanya kukubatsira iwe somunhu.
Sources:
National Cancer Institute. Munhu Mukuru Hasi-Hodgkin Lymphoma Treatment - Health Professional Version (PDQ). Updated 01/15/16. http://www.cancer.gov/types/lymphoma/hp/adult-nhl-treatment-pdq